Penn TREC Survivor Center

宾夕法尼亚 TREC 幸存者中心

• 批准号: 8072520
• 负责人: Kathryn H. Schmitz
• 金额: $ 19.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-24 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8072520
• 关键词: Address; Adopted; Adverse effects; Adverse event; Animals; Attenuated; Back; Basic Science; Biological Markers; Biometry; Body Weight decreased; Cancer Biology; Cancer Survivor; Cancer Survivorship; Categories; Clinical; Clinical Oncology; Clinical Trials; Cost Effectiveness Analysis; Costs and Cost Analysis; Detection; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Economic Policy; Education; Education and Outreach; Ensure; Epidemiology; Equilibrium; Exercise; Exercise Physiology; Face; Fostering; Funding; Generations; Glues; Goals; Growth; Health; Health Personnel; Health Policy; Human; Individual; Institution; Intervention; Knowledge; Left; Length; Life; Link; Lymphedema; Malignant Neoplasms; Methodology; Mission; Modeling; Molecular and Cellular Biology; Motivation; Mus; Nature; Obesity; Outcome; Pathway interactions; Physical Function; Physical Medicine; Physicians; Policies; Population; Public Health; Quality of life; Recurrence; Recurrent Malignant Neoplasm; Rehabilitation therapy; Research; Research Personnel; Research Training; Resources; Risk; Science; Scientist; Side; Survivors; T-Cell Receptor-Rearrangement Excision DNA Circles; Testing; The Sun; Time; Training; Training Activity; Training and Education; Translating; Translational Research; Ursidae Family; Vision; Weight maintenance regimen; Work; cancer recurrence; cancer site; cancer therapy; clinical application; clinical care; cost; cost effective; cost effectiveness; dissemination research; energy balance; health economics; improved; interest; intervention effect; malignant breast neoplasm; model development; mouse model; obesity treatment; organizational structure; outreach; outreach program; prevent; programs; sedentary; weight loss intervention

The overall goal of the Penn TREC Survivor Center is to improve the length and quality of cancer survivorship through establishing a sustainable transdisciplinary research, education, and outreach program that extends from 'bench to trench'. The proposed center will enhance knowledge of the causal associations of energy balance and breast cancer recurrence, from animal to human models, as well as exploring and integrating this knowledge with broad population impact at the policy level for control of obesity related adverse events among cancer survivors. Three projects are proposed. Project 1 will explore whether exercise and/or weight loss will alter breast cancer recurrence in mice and explore effects on biomarkers of mechanistic pathways hypothesized to explain these effects. Project 2 will translate project 1 biomarker findings into a human model. Intervention effects on clinical lymphedema outcomes will also be assessed in Project 2. Project 3 will assess whether exercise and/or weight loss is cost effective for breast cancer survivors with lymphedema. Organizationally, the administrative core will serve as the glue between the investigators, so that as the projects, training activities, and developmental pilots unfold, the transdisciplinary, translational nature ofthe center is preserved and extended. The developmental core will accelerate capacity to study effects of energetics on cancer recurrence by combining the unique strengths of our institution in obesity and cancer biology and extending the TREC initiative solidly into cancer survivorship. The education/training and outreach core will train scientists and clinicians regarding energy balance and cancer survivorship, serving the dual purpose of educating health care providers regarding the unique energy balance issues in survivors and spurring interest in research on this growing population across the spectrum from basic science to clinical applications. The Penn TREC Survivor Center will leverage the considerable strengths of Penn scientific investigators and physician scientists to accelerate capacity for research on energetics, cancer recurrence and persistent adverse treatment effects as well as disseminating those findings to improve clinical care and outcomes for cancer survivors.

宾大TREC幸存者中心的总体目标是通过建立一个可持续的跨学科研究、教育和推广项目，从“长凳”延伸到“战壕”，提高癌症幸存者的生存时间和质量。该中心将加强对能量平衡和乳腺癌复发的因果关系的认识，从动物到人类模型，以及探索和整合这些知识在政策层面上对肥胖相关控制的广泛人口影响