STRENGTH TRAINING FOR OBESITY PREVENTION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。最近肥胖率的上升使预防肥胖症成为一个明确而紧迫的公共卫生问题。美国女性平均每年增重约0.5公斤，其中60%到80%可以被认为是肥胖。25岁至44岁的超重女性体重显著增加(BMI增加5公斤/平方米)的发生率高于男性或年龄较大或较瘦的女性。腹部总脂肪和内脏脂肪增加与各种肥胖并存有关，包括胰岛素抵抗、高血压和血脂异常。成功减肥和保持减肥的困难导致了几个专家小组的建议，建议超重和轻度肥胖的人避免体重增加，而不是减肥。据观察，身体活动随着年龄的增长而下降，而卡路里摄入量保持稳定或略有下降。有强有力的观察证据表明，体育锻炼可以防止或减缓与年龄相关的脂肪增加。这项随机、对照的行为干预试验将检验这样一种假设，即在两年内定期参加每周两次的力量训练计划，可以防止80名年龄在25岁至44岁之间的超重至轻度肥胖(BMI 25-25 kg/m2)绝经前妇女(BMI 25-25 kg/m2)的年龄相关体脂增加(总和腹部脂肪)，与“标准护理组”(n=80)相比。这项研究的总体目标是防止身体脂肪增加，并减少与肥胖相关的健康风险。治疗效果将通过胰岛素敏感性、血压、血脂、肌肉力量和力量训练依从性的心理社会预测指标进行评估。这种方法的创新之处在于它的简单性和充分参与的最短时间要求(每周两次锻炼)。这一创新方法的初步研究结果是，88%的人在12个月内参加了锻炼，并在试点研究测量结束时(9个月)维持了对全身脂肪百分比的治疗效果。这支持了拟议干预方法的可行性和长期效果的潜力。这项有效性试验的成功的长期含义是，这种适度的行为改变可以防止中年女性常见的肥胖增加和相关的并发症。GCRC的作用：身高和体重测量；静息血压；全身DEXA扫描的身体成分；DEXA扫描的骨密度；抽取10汤匙血液并准备储存；胰岛素改良的静脉葡萄糖耐量试验。测量发生在基线、第一年和第二年。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent obesity prevalence increases have made obesity prevention a clear and pressing public health issue. The average US woman gains about 0.5 kg per year, 60 to 80% of which can be assumed to be fat. Overweight women aged 25 to 44 have a higher prevalence of significant weight gains (BMI increases of 5 kg/m2) than men or older or thinner women. Total and viseral abdominal fat gains are associated with a variety of obesity co-morbidities, including insulin resistance, hypertension, and dyslipidemia. The difficulty in successfully losing weight and maintaining weight loss has resulted in recommendations from several expert panels to advise overweight and mildly obese individuals to avoid weight gains rather than lose weight. Physicial activity is observed to decline with age while caloric intake remains stable or declines slightly. There is strong observational evidence that physical activity could prevent or attenuate age associated fat gains. This randomized, controlled behavioral interventional trial will test the hypothesis that regular participation twice weekly strength training program over 2 years, can prevent age associated body fat increases (total and siceral abdominal fat) in 80 overweight to mildly obese premenopausal women( BMI 25-25 kg/m2) between the ages of 25 and 44 years, compared to a "standard care group" (n=80). The overall aim of the study is to prevent body fat gains and to reduce health risks associated with obesity. Treatment effects will be assessed for insulin sensitivity, blood pressure, blood lipids, muscle strength, and psychosocial predictors of strength training adherence. The innovation of this approach rests in its simplicity and the minimal time requirement for full participation (2 exercise sessions weekly). A preliminary study of this innovative approach resulted in 88% exercise attendance over 12 months and maintenance of treatment effects on total body fat percentage to the end of pilot study measurements (9 months). This supports the feasibility and potential for long term efficacy of the proposed intervention approach. The long-term implication of success in this efficacy trial would be that this modest behavior change could prevent the fat gains and associated co-morbidities commonly observed in midlife women. Role of GCRC: Height and weight measurements; resting blood pressure; body composition by total body DEXA Scan; bone mineral density by DEXA scan; blood draw of 10 tablespoons of blood and prep to store; insulin modified intravenous glucose tolerance test. Measurements to occur at baseline, year 1, and year 2.