2013 Salivary Glands and Exocrine Biology Gordon Research Conference

描述（由申请人提供）：本提案请求对题为“从发育到疾病及其他”的第九届戈登研究会议“唾液腺和外分泌生物学”提供部分支持，该会议将于 2013 年 2 月 3 日至 8 日在德克萨斯州加尔维斯顿的加尔维兹酒店举行。这次会议非常重要，因为唾液腺在口腔和全身健康中发挥着关键作用，并且它们可以作为分支形态发生、外分泌生理学和外分泌功能障碍（包括自身免疫性疾病和癌症）的一般研究的有用模型系统。此外，这次会议是唾液腺和外分泌组织生物学领域的一次杰出的多学科会议，汇集了成熟的基础和转化研究人员、有前途的初级科学家和相关领域的专家。本次会议的总体目标是加快唾液和外分泌组织生物学领域的研究进展，并利用研究成果开发唾液和其他外分泌组织功能障碍的新疗法。第二个目标是促进唾液研究人员和研究人员在互补的基础、转化和临床领域之间的合作。会议的目标将通过两个具体目标来实现：1）促进与相关的未来重要研究方向的讨论和优先排序 了解唾液腺和其他外分泌组织及其分泌物的发育、生理学和病理生理学，包括最先进的诊断和治疗进展，2) 为研究生、博士后和初级教师级别的初级研究人员提供一个场所，讨论他们当前的研究并建立包括合作在内的科学互动。后者被视为年轻研究人员建立网络的重要一步，这可能会带来终生的合作和科学成就。这可能会促进保留该领域最有才华的初级研究人员。该计划将包括九场全体会议，其中包括国际知名调查人员的两次主题演讲。此外，四场海报会议将作为展示新研究成果的场所。会议的主要主题将集中在：1）发育的分子遗传机制； 2）蛋白质和液体分泌的机制； 3）钙信号传导机制； 4) 外分泌病和恶性肿瘤，以及 5) 组织修复和再生。该计划的一个重要特点是扩大关注范围，包括机械转导/组织形态动力学、肿瘤生物学和可塑性、炎症和纤维化、基因组学、转录组学和表观基因组学的进展，以及细胞过程计算模型的更新。其他亮点将包括尖端技术和方法的介绍。此次会议将促进将最新的突破性发现和创新技术与唾液腺功能障碍新疗法的开发结合起来，并进一步推动创新的唾液和外分泌组织研究。

DESCRIPTION (provided by applicant): This proposal requests partial support for the ninth Gordon Research Conference on "Salivary Glands and Exocrine Biology" entitled From Development to Disease and Beyond, to be held February 3-8, 2013, at the Hotel Galvez, Galveston, Texas. This meeting is highly significant because salivary glands perform critical roles in oral and systemic health, and they can serve as useful model systems for general studies of branching morphogenesis, exocrine physiology and exocrine dysfunctions, including autoimmune diseases and cancer. Moreover, the meeting is a preeminent multi-disciplinary conference in the fields of salivary gland and exocrine tissue biology that brings together established basic and translational investigators, promising junior scientists, and experts from associated fields. The overall goal of this conference is to expedite progress in research in the area of salivary and exocrine tissue biology and to use research findings for the development of new therapies for salivary and other exocrine tissue dysfunctions. A secondary goal is to facilitate collaborations among salivary researchers and investigators in complementary basic, translational and clinical fields. The goals of the meeting will be met through two specific aims: 1) to promote discussion and prioritization of the important future research directions relevant to understanding the development, physiology, and pathophysiology of salivary glands and other exocrine tissues and their secretions, including state-of-the-art diagnostic and therapeutic advances, and 2) to provide a venue for junior investigators at the graduate student, postdoctoral and junior faculty levels to discuss their current research and forge scientific interactions including collaborations. The latter is viewed as an essential step to young investigators to build networks that may lead to a lifetime of collaboration and scientific achievement. This is likely to promote the retention of the most talented junior investigators in the field. The program will comprise nine plenary sessions, including two keynote addresses by investigators of international stature. In addition, four poster sessions will serve as a venue to showcase new research findings. The major themes of the meeting will focus on: 1) molecular genetic mechanisms of development; 2) mechanisms of protein and fluid secretion; 3) mechanisms of calcium signaling; 4) exocrineopathies and malignancies, and 5) tissue repair and regeneration. An important feature of the program will be a broadening of focus to include mechanotransduction/tissue morphodynamics, tumor biology and plasticity, inflammation and fibrosis, advances in genomics, trascriptomics and epigenomics, as well as updates on computational modeling of cellular processes. Additional highlights will include presentation of cutting edge technologies and methodologies. The meeting will facilitate the aligning of recent breakthrough discoveries and innovative technologies with the development of new therapies for salivary gland dysfunctions and further drive innovative salivary and exocrine tissue research.