Using Novel Behavioral Approaches to Improve Long-Term Weight Loss Outcomes

使用新颖的行为方法来改善长期减肥效果

• 批准号: 8580090
• 负责人: JASON LILLIS
• 金额: $ 17.42万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8580090
• 关键词: Address; Applications Grants; Area; Award; Behavior; Behavior Therapy; Behavioral; Behavioral Medicine; Behavioral Model; Body Weight; Body Weight decreased; Clinical; Cognitive; Cognitive Therapy; Commit; Control Groups; Development; Diabetes Mellitus; Direct Costs; Eating; Educational process of instructing; Educational workshop; Emotional; Exercise; Facilities and Administrative Costs; Faculty; Feeling; Food; Frequencies; Funding; Generations; Goals; Grant; Health; Health Personnel; Health behavior change; Hospitals; Human; Individual; Informal Social Control; Intervention; Journals; K-Series Research Career Programs; Laboratory Research; Lead; Leadership; Learning; Maintenance; Manuscripts; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Obesity; Oral; Outcome; Outcomes Research; Overweight; Pain; Paper; Participant; Physical activity; Pilot Projects; Positioning Attribute; Preparation; Preventive Medicine; Productivity; Psychiatry; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recording of previous events; Relapse; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Role; Scientist; Site; Solutions; Statistical Methods; Structure; Techniques; Testing; Therapeutic Intervention; Thinking; Training; United States National Institutes of Health; Universities; Waiting Lists; Weight; Weight Gain; Weight maintenance regimen; Wing; Writing; base; bodily sensation; clinical practice; comparative efficacy; cooking; coping; data management; design; emotional experience; experience; flexibility; follow-up; food consumption; improved; innovation; lifestyle intervention; medical schools; meetings; member; mindfulness; novel; nutrition; obesity treatment; patient oriented research; peer; primary outcome; professor; programs; psychologic; psychological outcomes; public health relevance; response; secondary outcome; skills; skills training; successful intervention; therapy design; training project; trial comparing; weight maintenance

DESCRIPTION (provided by applicant): This proposal is for a Mentored Patient-Oriented Research Award (K23) for a promising young scientist: Dr. Jason Lillis. There is a critical need for treatment innovation to develop new clinical methods that promote better long-term weight control outcomes. Dr. Lillis has excellent training and skills in Acceptance and Commitment Therapy (ACT), a newer cognitive behavioral treatment approach, which has shown potential for improving long-term weight control outcomes. Dr. Lillis has also shown a commitment to researching obesity treatment; however he has received little formal training in obesity. His commitment to focusing on obesity treatment research led him to his current position as Assistant Professor (Research) at the Weight Control and Diabetes Research Center (WCDRC) at The Miriam Hospital and the Alpert Medical School of Brown University's Department of Psychiatry. The WCDRC is a premiere obesity research center led by Dr. Rena Wing. The goal of the this Mentored Patient-Oriented Research Award (K23) proposal is to allow Dr. Lillis to further develop as an independent investigator studying the use of innovative methods for the treatment of obesity. In order further pursue this program of research it is necessary for Dr. Lills to receive broad, formal training in obesity and obesity treatment. Through this K23 award, Dr. Lillis will establish expertise in obesity and current best practice treatment of obesity, as well s further develop the necessary skills to design and conduct funded outcome research applying expertise in ACT to the area of obesity. To accomplish this, Dr. Lillis will commit 100% effort to his training and this project for each year of the award. Through mentorship under Dr. Wing and an expert co-mentor team, Dr. Lillis will: receive training in the causes and health consequences of obesity, and the roles of physical activity and [nutrition] in weight loss treatment; develop expertise in the behavioral approach to weight loss and the objective assessment of important factors related to weight control; gain additional experience in the design and conduct of randomized clinical trials; develop expertise in statistical methods; develop professionally through manuscript preparation, grant writing, and oral presentations; and continue to learn about and practice the responsible conduct of scientific research. Dr. Lillis' long-term goals are: to continue to establish an innovative program of research on the use of novel methods to improve long-term weight control outcomes, establish an independent research laboratory, and provide training and mentorship to junior scientists. The primary site for this award is the Weight Control and Diabetes Research Center (WCDRC). Dr. Wing is the Director of the WCDRC, which has its own 17,000+ sq. ft. state of the art, fully staffed facility. Dr. Lillis and 10 other faculty members, all of whom are involved in NIH-funded research projects, meet weekly to discuss research ideas, results, grant applications, and manuscripts; and the entire WCDRC staff meet for journal club to review recent papers relevant to obesity research. The WCDRC is part of the Centers for Behavioral and Preventive Medicine (CBPM) at The Miriam Hospital, which has an excellent research infrastructure to support trainee development, including centralized leadership and administration, grant oversight, data management and programming, and peer and external quality review of all research proposals prior to submission. The WCDRC is also a part of the Department of Psychiatry and Human Behavior (DPHB) at the Alpert Medical School of Brown University; which has a strong commitment by senior research faculty to mentor, a long history of training post-graduates in patient-oriented research through the K Award mechanism, and the structure in place so that a Mentored Research Scientist Development Award can be implemented effectively. Obesity is a major public health problem, and improving long-term weight loss outcomes is a difficult challenge for the field. Dr. Lillis conducted a pilot study testing an ACT workshop for weight maintenance, which showed improved maintenance and further weight loss at 3 months. ACT is a new generation behavioral therapy and is designed to increase psychological flexibility; or the ability to develop and persis in behavior consistent with one's values in the presence of unwanted thoughts, feelings, and bodily sensations. This acceptance-based approach is theoretically-driven, and presents an alternative to current traditional CBT approaches normally applied to weight loss treatment. The primary aim of the proposed K23 is to conduct a randomized controlled trial comparing the efficacy of an ACT approach, an empirically supported Self-Regulation approach (based on a traditional behavioral model) and a control group for long-term weight loss. All participants will first participate in an initial 16-week standard behavioral weight loss program. At the end of the program, participants will be randomized to [receive a workshop intervention delivered in 3 sessions across 6 months: ACT, Self- Regulation, or a cooking demonstration control group. Assessments will occur at baseline, 4, 12, 18, and 24 months.] The primary hypothesis is that the ACT condition will have better weight loss at 24 months. This project is significant in that it tests an innovative treatment approach designed to improve long-term weight loss outcomes, one of the biggest challenges to the field of obesity.

描述（由申请人提供）：本提案为有前途的年轻科学家Jason Lillis博士申请指导患者导向研究奖（K23）。迫切需要创新治疗方法，开发新的临床方法，以促进更好的长期体重控制结果。利利斯博士在接受和承诺疗法（ACT）方面接受过出色的培训，并拥有出色的技能。ACT是一种较新的认知行为治疗方法，已显示出改善长期体重控制结果的潜力。利利斯博士还表现出致力于研究肥胖治疗的决心；然而，他几乎没有接受过关于肥胖的正式培训。他致力于肥胖症治疗研究，目前担任Miriam医院体重控制和糖尿病研究中心（WCDRC）和布朗大学精神学系Alpert医学院的助理教授（研究）。WCDRC是由Rena Wing博士领导的首屈一指的肥胖研究中心。本次指导患者导向研究奖（K23）提案的目标是允许Lillis博士进一步发展为一名独立研究者，研究使用创新方法治疗肥胖。为了进一步开展这一研究项目，利斯博士有必要在肥胖和肥胖治疗方面接受广泛而正式的培训。通过这个K23奖项，Lillis博士将在肥胖和目前的最佳实践治疗肥胖方面建立专业知识，并进一步发展必要的技能，以设计和实施资助的成果研究，将ACT的专业知识应用于肥胖领域。为了实现这一目标，Lillis博士将在每年的奖项中为他的培训和这个项目投入100%的努力。在Wing博士和一个专家联合导师团队的指导下，Lillis博士将：接受关于肥胖的原因和健康后果的培训，以及体育活动和[营养]在减肥治疗中的作用；在减肥的行为方法和客观评估与体重控制有关的重要因素方面发展专业知识；在随机临床试验的设计和实施方面获得额外的经验；发展统计方法方面的专门知识；通过手稿准备，拨款写作和口头报告来发展专业；并继续学习和实践负责任的科学研究行为。利利斯博士的长期目标是：