Using Novel Behavioral Approaches to Improve Long-Term Weight Loss Outcomes

使用新颖的行为方法来改善长期减肥结果

• 批准号: 8727541
• 负责人: JASON LILLIS
• 金额: $ 17.22万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8727541
• 关键词: Address; Applications Grants; Area; Award; Behavior; Behavior Therapy; Behavioral; Behavioral Medicine; Behavioral Model; Body Weight; Body Weight decreased; Clinical; Cognitive; Cognitive Therapy; Commit; Control Groups; Development; Diabetes Mellitus; Direct Costs; Eating; Educational process of instructing; Educational workshop; Emotional; Exercise; Facilities and Administrative Costs; Faculty; Feeling; Food; Frequencies; Funding; Generations; Goals; Grant; Health; Health Personnel; Health behavior change; Hospitals; Human; Individual; Informal Social Control; Intervention; Journals; K-Series Research Career Programs; Laboratory Research; Lead; Leadership; Learning; Maintenance; Manuscripts; Mediating; Mentored Patient-Oriented Research Career Development Award; Mentored Research Scientist Development Award; Mentors; Mentorship; Methods; Modeling; Monitor; Obesity; Oral; Outcome; Outcomes Research; Overweight; Pain; Paper; Participant; Physical activity; Pilot Projects; Positioning Attribute; Preparation; Preventive Medicine; Productivity; Psychiatry; Public Health; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recording of previous events; Relapse; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Proposals; Role; Scientist; Site; Solutions; Statistical Methods; Structure; Techniques; Testing; Therapeutic Intervention; Thinking; Training; United States National Institutes of Health; Universities; Waiting Lists; Weight; Weight Gain; Weight maintenance regimen; Wing; Writing; base; bodily sensation; clinical practice; comparative efficacy; cooking; coping; data management; design; emotional experience; experience; flexibility; follow-up; food consumption; improved; innovation; lifestyle intervention; medical schools; meetings; member; mindfulness; novel; nutrition; obesity treatment; patient oriented research; peer; primary outcome; professor; programs; psychologic; psychological outcomes; public health relevance; response; secondary outcome; skills; skills training; successful intervention; therapy design; training project; trial comparing; weight maintenance

DESCRIPTION (provided by applicant): This proposal is for a Mentored Patient-Oriented Research Award (K23) for a promising young scientist: Dr. Jason Lillis. There is a critical need for treatment innovation to develop new clinical methods that promote better long-term weight control outcomes. Dr. Lillis has excellent training and skills in Acceptance and Commitment Therapy (ACT), a newer cognitive behavioral treatment approach, which has shown potential for improving long-term weight control outcomes. Dr. Lillis has also shown a commitment to researching obesity treatment; however he has received little formal training in obesity. His commitment to focusing on obesity treatment research led him to his current position as Assistant Professor (Research) at the Weight Control and Diabetes Research Center (WCDRC) at The Miriam Hospital and the Alpert Medical School of Brown University's Department of Psychiatry. The WCDRC is a premiere obesity research center led by Dr. Rena Wing. The goal of the this Mentored Patient-Oriented Research Award (K23) proposal is to allow Dr. Lillis to further develop as an independent investigator studying the use of innovative methods for the treatment of obesity. In order further pursue this program of research it is necessary for Dr. Lills to receive broad, formal training in obesity and obesity treatment. Through this K23 award, Dr. Lillis will establish expertise in obesity and current best practice treatment of obesity, as well s further develop the necessary skills to design and conduct funded outcome research applying expertise in ACT to the area of obesity. To accomplish this, Dr. Lillis will commit 100% effort to his training and this project for each year of the award. Through mentorship under Dr. Wing and an expert co-mentor team, Dr. Lillis will: receive training in the causes and health consequences of obesity, and the roles of physical activity and [nutrition] in weight loss treatment; develop expertise in the behavioral approach to weight loss and the objective assessment of important factors related to weight control; gain additional experience in the design and conduct of randomized clinical trials; develop expertise in statistical methods; develop professionally through manuscript preparation, grant writing, and oral presentations; and continue to learn about and practice the responsible conduct of scientific research. Dr. Lillis' long-term goals are: to continue to establish an innovative program of research on the use of novel methods to improve long-term weight control outcomes, establish an independent research laboratory, and provide training and mentorship to junior scientists. The primary site for this award is the Weight Control and Diabetes Research Center (WCDRC). Dr. Wing is the Director of the WCDRC, which has its own 17,000+ sq. ft. state of the art, fully staffed facility. Dr. Lillis and 10 other faculty members, all of whom are involved in NIH-funded research projects, meet weekly to discuss research ideas, results, grant applications, and manuscripts; and the entire WCDRC staff meet for journal club to review recent papers relevant to obesity research. The WCDRC is part of the Centers for Behavioral and Preventive Medicine (CBPM) at The Miriam Hospital, which has an excellent research infrastructure to support trainee development, including centralized leadership and administration, grant oversight, data management and programming, and peer and external quality review of all research proposals prior to submission. The WCDRC is also a part of the Department of Psychiatry and Human Behavior (DPHB) at the Alpert Medical School of Brown University; which has a strong commitment by senior research faculty to mentor, a long history of training post-graduates in patient-oriented research through the K Award mechanism, and the structure in place so that a Mentored Research Scientist Development Award can be implemented effectively. Obesity is a major public health problem, and improving long-term weight loss outcomes is a difficult challenge for the field. Dr. Lillis conducted a pilot study testing an ACT workshop for weight maintenance, which showed improved maintenance and further weight loss at 3 months. ACT is a new generation behavioral therapy and is designed to increase psychological flexibility; or the ability to develop and persis in behavior consistent with one's values in the presence of unwanted thoughts, feelings, and bodily sensations. This acceptance-based approach is theoretically-driven, and presents an alternative to current traditional CBT approaches normally applied to weight loss treatment. The primary aim of the proposed K23 is to conduct a randomized controlled trial comparing the efficacy of an ACT approach, an empirically supported Self-Regulation approach (based on a traditional behavioral model) and a control group for long-term weight loss. All participants will first participate in an initial 16-week standard behavioral weight loss program. At the end of the program, participants will be randomized to [receive a workshop intervention delivered in 3 sessions across 6 months: ACT, Self- Regulation, or a cooking demonstration control group. Assessments will occur at baseline, 4, 12, 18, and 24 months.] The primary hypothesis is that the ACT condition will have better weight loss at 24 months. This project is significant in that it tests an innovative treatment approach designed to improve long-term weight loss outcomes, one of the biggest challenges to the field of obesity.

描述（由申请人提供）：本提案是为一位有前途的年轻科学家Jason Lillis博士颁发的指导性患者导向研究奖（K23）。迫切需要治疗创新，以开发新的临床方法，促进更好的长期体重控制结果。Lillis博士在接受和承诺疗法（ACT）方面有着出色的培训和技能，ACT是一种较新的认知行为治疗方法，已显示出改善长期体重控制结果的潜力。Lillis博士还致力于研究肥胖治疗;然而，他几乎没有接受过肥胖方面的正式培训。他专注于肥胖治疗研究的承诺使他成为Miriam医院体重控制和糖尿病研究中心（WCDRC）和布朗大学精神病学系Alpert医学院的助理教授（研究）。WCDRC是一个由雷纳翼博士领导的首屈一指的肥胖研究中心。该指导患者导向研究奖（K23）提案的目标是让Lillis博士进一步发展为研究使用创新方法治疗肥胖症的独立研究者。为了进一步开展这项研究计划，Lills博士有必要接受广泛的，正式的肥胖和肥胖治疗培训。通过这个K23奖，Lillis博士将建立肥胖和目前肥胖最佳实践治疗的专业知识，以及进一步发展必要的技能，设计和进行资助的成果研究，将ACT的专业知识应用于肥胖领域。为了实现这一目标，Lillis博士将致力于100%的努力，他的培训和这个项目的每一年的奖项。通过在Wing博士和专家共同导师团队的指导下，Lillis博士将：接受肥胖的原因和健康后果以及身体活动和[营养]在减肥治疗中的作用的培训;发展减肥行为方法和体重控制相关重要因素的客观评估的专业知识;在随机临床试验的设计和实施方面获得额外的经验;发展统计方法的专业知识;通过手稿准备，赠款写作和口头报告专业发展;并继续学习和实践科学研究的负责任行为。Lillis博士的长期目标是： 继续建立一个创新的研究计划，利用新方法改善长期体重控制结果，建立一个独立的研究实验室，并为年轻科学家提供培训和指导。该奖项的主要网站是重量 控制和糖尿病研究中心（WCDRC）。Wing博士是WCDRC的主任，该中心拥有自己的17，000多平方米。英尺最先进的设备配备齐全的设施利利斯博士和其他10名 所有参与NIH资助的研究项目的教职员工每周开会讨论研究思路、结果、资助申请和手稿; 2 WCDRC全体员工参加期刊俱乐部，审查与肥胖研究相关的最新论文。WCDRC是Miriam医院行为和预防医学中心（CBPM）的一部分，该中心拥有出色的研究基础设施，以支持学员发展，包括集中领导和管理，赠款监督，数据管理和编程，以及在提交之前对所有研究提案进行同行和外部质量审查。WCDRC也是布朗大学阿尔珀特医学院精神病学和人类行为系（DPHB）的一部分;高级研究教师对导师的坚定承诺，通过K奖机制培训研究生以患者为导向的研究的悠久历史，以及适当的结构，以便指导研究科学家发展奖可以有效实施。肥胖是一个主要的公共卫生问题，改善长期减肥结果是该领域的一个艰巨挑战。Lillis博士进行了一项试点研究，测试ACT工作坊的体重维持效果，结果显示3个月后维持效果得到改善，体重进一步减轻。ACT是一种新一代的行为疗法，旨在提高心理灵活性;或者在不必要的想法，感觉和身体感觉存在的情况下，发展和坚持与自己价值观一致的行为的能力。这种基于接受的方法是理论驱动的，并提出了一种替代目前传统的CBT方法通常适用于减肥治疗。拟议的K23的主要目的是进行一项随机对照试验，比较ACT方法、经验支持的自我调节方法（基于传统行为模型）和长期减肥对照组的功效。所有参与者将首先参加为期16周的标准行为减肥计划。在计划结束时，参与者将被随机分配到[接受6个月内3次会议提供的研讨会干预：ACT，自我调节或烹饪示范对照组。将在基线、4、12、18和24个月时进行评估。]主要假设是ACT条件将在24个月时具有更好的体重减轻。这个项目的重要性在于， 测试了一种创新的治疗方法，旨在改善长期减肥的结果，这是肥胖领域最大的挑战之一。