Phosphorus-based Food Additives, Mineral Metabolism and Cardiovascular Health

磷基食品添加剂、矿物质代谢和心血管健康

• 批准号: 8490374
• 负责人: Orlando M Gutierrez
• 金额: $ 17.67万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-20 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8490374
• 关键词: Address; Adverse effects; Alabama; American; Animals; Appearance; Biological Markers; Blood; Blood Vessels; Bone Diseases; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Cause of Death; Cessation of life; Chronic Kidney Failure; Clinical Research; Communities; Consumption; Data; Diet; Dietary Factors; Dietary Intervention; Dietary Phosphorus; Dilatation - action; Disease; Event; Food; Food Additives; Food Processing; Food Supply; Future; General Population; Health; Home environment; Hormones; Human; Individual; Industry; Inflammation; Intake; Kidney Diseases; Knowledge; Life; Link; Mediating; Metabolic; Metabolism; Minerals; Oral; Outcome; Outcome Study; Participant; Pathogenesis; Persons; Phosphorus; Phosphorus Metabolism Disorders; Physiological; Play; Population; Process; Public Health; Recommendation; Risk Factors; Role; Salts; Taste Perception; Testing; Time; Translational Research; United States Food and Drug Administration; Universities; Urine; Visit; base; brachial artery; design; fast food; feeding; fibroblast growth factor 23; food consumption; healthy volunteer; high risk; inorganic phosphate; modifiable risk; phosphorus metabolism; public health relevance; response; trend; vascular inflammation

DESCRIPTION (provided by applicant): Mounting evidence suggests that disturbances in phosphorus metabolism contribute to excess cardiovascular disease events and death independently of established risk factors. Excess dietary phosphorus intake plays a central role in the pathogenesis of these disorders. In the US, dietary phosphorus consumption far exceeds current recommendations for daily intake, in large part due to the nearly ubiquitous distribution of phosphorus-based food additives in the US food supply. These additives are heavily utilized by the food manufacturing industry to enhance the taste, appearance, and shelf-life of processed foods and thus, can substantially augment daily phosphorus intake in persons consuming convenience and fast foods typical of the American diet. While currently considered safe for public consumption by the US Food and Drug administration, recent data suggest that high intake of these additives may have important health consequences. High intake of phosphorus additives impaired cardiovascular health in animal and human studies. In addition, higher phosphorus intake stimulates the secretion of phosphorus-regulatory hormones such as fibroblast growth factor 23 (FGF23), elevated levels of which were associated with inflammation, cardiovascular disease events and death. These data suggest that excess intake of phosphorus-based food additives is an important and potentially modifiable risk factor for disturbed phosphorus metabolism, inflammation, and cardiovascular disease among millions of individuals consuming typical American diets. However, few physiological studies specifically examined the effect of excess commercial phosphorus additive intake on phosphate metabolism and cardiovascular function in healthy volunteers. This is the central focus of this application. Specifically, we will (1) determine the effect of additive-enhanced foods on blood phosphate and FGF23 levels, and biomarkers of inflammation, and (2) determine the effect of additive-enhanced foods on vascular reactivity in healthy volunteers. Participants will consume standardized diets prepared by the metabolic kitchen of the University of Alabama Clinical Research Unit over a 4-week period of time. Blood and urine parameters will be collected throughout the dietary intervention periods to assess study outcome variables. In addition, brachial artery flow mediated dilatation will be assessed before and after the dietary interventions to determine the effects of phosphorus additives on vascular function. These results will provide critical pilot data for the design and implementation of futur interventional studies aimed at examining the impact of modulating phosphorus-based food additives on mineral metabolism and cardiovascular health across the spectrum of kidney disease.

描述（由申请人提供）：越来越多的证据表明，磷代谢紊乱导致心血管疾病事件和死亡过多，独立于已确定的危险因素。过量的膳食磷摄入在这些疾病的发病机制中起着核心作用。在美国，膳食中磷的摄入量远远超过目前的每日推荐摄入量，这在很大程度上是由于美国食品供应中几乎无处不在的含磷食品添加剂。食品制造业大量使用这些添加剂来改善加工食品的味道、外观和保质期，因此，可以大大增加人们每天的磷摄入量，这些人食用美国饮食中典型的方便食品和快餐。虽然目前美国食品和药物管理局认为公众消费是安全的，但最近