用于治疗急性肝衰竭的细胞装置-猫眼课题宝

用于治疗急性肝衰竭的细胞装置

批准号：

8442924

负责人：

Biju Parekkadan

金额：

$19.14万

依托单位：

SENTIEN BIOTECHNOLOGIES, INC.

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-04-01 至 2015-03-31

来源：

https://reporter.nih.gov/project-details/8442924

关键词：

Acetaminophen Achievement Acute Acute Kidney Failure Acute Liver Failure Address Ally Animal Model Animals Anti-Inflammatory Agents Anti-inflammatory Artificial Liver Bioreactors Biotechnology Blood Businesses Canis familiaris Cell Count Cell Survival Cell physiology Cell secretion Cells Chronic Clinic Clinical Commit Complex Critical Illness Data Development Devices Dose Drug Delivery Systems Engineering Environment Fiber Functional disorder Funding Germ Cells Glycocalyx Goals Hepatocyte Hepatology Human Hybrids Image Imaging Device Immune response Inflammation Inflammatory Injection of therapeutic agent Investments Letters Liver Liver Failure Marketing Medical Membrane Mesenchymal Stem Cells Methods Modeling Monitor Nutrient Organ Organ failure Patients Phase Plant Roots Poisoning Positron-Emission Tomography Procedures Property Rattus Simulate Small Business Innovation Research Grant Stem cells Subcutaneous Injections Technology Testing Therapeutic Therapy Clinical Trials Time Tissue Engineering Translating Transplantation base bioimaging chronic liver disease clinical efficacy clinically relevant combinatorial commercialization cost effective therapy in vivo injured liver transplantation mortality operation patient population pre-clinical programs prototype regenerative repaired single molecule tissue repair tool

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中文摘要

翻译

描述（由申请人提供）：这个I期项目的目标是开发一种用于治疗急性肝衰竭的细胞包被装置。该装置利用间充质干细胞分泌物提供联合抗炎和再生支持。该项目的具体目标是：(1)正电子发射断层扫描（PET）引导下的细胞涂层优化；(2)在对乙酰氨基酚诱导的狗肝衰竭模型中进行剂量递增治疗试验。这个完成的项目的交付将是治疗的证明

英文摘要

DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a cell-coated device for the treatment of acute liver failure. The device harnesses mesenchymal stem cell secretions to provide combined anti-inflammatory and regenerative support. The project specific aims are: (1) Positron emission tomography (PET)-guided optimization of cellular coatings; and (2) To perform a dose escalation therapeutic trial in an acetaminophen-induced liver failure model in dogs. The deliverable of this completed project will be therapeutic proof-of concept data that can be optimized in large animals during Phase II funding.

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