Artificial, Humanized Stem Cell Niches

人工、人性化干细胞生态位

• 批准号: 8469758
• 负责人: Biju Parekkadan
• 金额: $ 58.29万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8469758
• 关键词: 3-Dimensional; Anemia; Biocompatible Materials; Biomedical Engineering; Biomimetics; Bone Marrow; Bone Marrow Diseases; Bone Marrow Transplantation; CD34 gene; Cell Density; Cell Therapy; Cell secretion; Cells; Chronic; Clinical Protocols; Complication; Controlled Environment; Development; Disease; Engraftment; Extramedullary Hematopoiesis; Failure; Goals; Health; Hematology; Hematopoiesis; Hematopoietic; Hematopoietic Stem Cell Transplantation; Hematopoietic stem cells; Human; Image; Implant; Implantation procedure; Infusion procedures; Intravenous; Lymphoid Tissue; Malignant Neoplasms; Marrow; Methods; Monitor; Mus; Organ; Pancytopenia; Patients; Physiology; Positioning Attribute; Preparation; Procedures; Protocols documentation; Quality Control; Radiology Specialty; Recovery; Recruitment Activity; Research Personnel; Risk; Route; Site; Skin; Source; Spleen; Stem cells; Stromal Cells; Testing; Therapeutic; Thymus Gland; Time; Translating; Transplantation; Umbilical Cord Blood; Withdrawal; base; design; implantation; insight; lymph nodes; novel; peripheral blood; potency testing; preclinical study; quality assurance; scale up; self-renewal; stem; stem cell biology; stem cell niche

DESCRIPTION (provided by applicant): The overall goal of this project is to optimize and deploy a bioengineered implant to increase the apparent space for transplanted hematopoietic stem cells during states of marrow failure. The project specific aims are: (1) Identify critical manufacturing parameters of the implant. (2) Design a clinical protocol for use of implants to rescue bone marrow failure, and (3) Image-guided monitoring of the implant therapy. Our expected contribution is the development of a novel bioengineered bone marrow patch that is significant because the protocols developed here could rescue thousands of patients who die from marrow failure by making marrow transplantation more efficient.

描述（由申请人提供）：本项目的总体目标是优化和部署生物工程植入物，以增加骨髓衰竭状态下移植造血干细胞的表观空间。该项目的具体目标是：（1）确定植入物的关键制造参数。(2)设计使用植入物挽救骨髓衰竭的临床方案;（3）植入物治疗的图像引导监测。我们的预期贡献是开发一种新的生物工程骨髓补片，这是重要的，因为这里开发的协议可以通过使骨髓移植更有效来挽救数千名死于骨髓衰竭的患者。