Chronic Kidney Disease Knowledge and Awareness among American Indians

描述（由申请人提供）：候选人。该 K23 奖项的总体目标是为阿拉斯加原住民学术普通内科医生 Stacey Jolly 博士提供培训、研究技能、经验和专业发展，以建立慢性肾病相关研究的独立项目。她提出的培训计划由三个核心组成部分组成：（1）基于社区的转化研究原则； (2) 定性方法和调查设计； (3) 前瞻性临床试验的方法、实施和评估。她为每个组成部分提出了正式的课程作业、教程和实践经验。她将学习并融入基于社区的转化研究原则。她将在定性和混合方法研究领域发展新的分析技能。她将学习如何将丰富的定性数据转化为定量方法，特别是调查开发。她将学习如何以美国印第安人制作的计算机化数字故事的形式创建文化和内容适当的慢性肾病教育材料。她将在一项试点介入试验中测试这种创造性的方式，目的是提高美国印第安人对慢性肾脏病的了解和认识以及慢性肾脏病的保护行为，并评估可行性、可接受性和效果大小。完成后，她将非常适合获得独立研究经费。她的职业生涯不仅将作为一名医师研究员取得进展，而且还将在学术医学领域取得进展，并从助理晋升为副教授级别。环境。克利夫兰诊所、克利夫兰诊所勒纳医学院及其附属凯斯西储大学是俄亥俄州克利夫兰的主要教育和研究机构。 Jolly 博士是凯斯西储大学克利夫兰诊所勒纳医学院的医学助理教授。她将受益于丰富的多学科指导和培训环境，其中包括肾脏病学、定性方法、公共卫生、流行病学、生物统计学和健康差异研究方面的专家。 Ashwini Sehgal 博士是凯斯西储大学的医学教授，也是减少健康差距案例中心的首席研究员，他将担任 Jolly 博士的主要导师。斯佩罗·曼森 (Spero Manson) 博士是科罗拉多大学丹佛分校的医学教授，也是美洲印第安人和阿拉斯加原住民健康中心的首席研究员，他将担任联合导师。 Cheryl Killion 博士是凯斯西储大学护理学副教授，定性方法专家将担任联合导师。 Jolly 博士汇集了一支多元化的导师团队、顾问和咨询委员会成员，他们提供丰富的研究经验，特别是在美洲印第安人中的研究经验，并支持她的职业发展计划。她的研究项目和数据收集地点将在南达科他州，在那里她将与密苏里州 Breaks Research Industries, Inc. 的 Marcia O'Leary 运营的强心脏研究达科他中心密切合作。强心脏研究是一项由 NIH/NHLBI 资助的完善研究。研究项目。该项目的目标是评估北部平原患有代谢综合征的美洲印第安人对慢性肾脏病的了解和认识。之前对普通人群和一些受慢性肾病不利影响的少数人群进行的研究表明，人们对该病的了解和认识较低。据我们所知，还没有研究详细调查美洲印第安人对慢性肾脏病的知识、意识和信仰。本研究建议开展一系列焦点小组活动，并开展慢性肾脏病知识和意识调查。在有早期慢性肾病风险或患有早期慢性肾病的人群中进行的教育干预临床试验很少。据我们所知，没有人使用数字讲故事作为传递教育信息的手段，并且没有在美国印第安人中进行过这种方式，而美国印第安人是慢性肾病和终末期肾病患病率很高的群体。 该研究项目的目标是： 1) 量化患有代谢综合征的美洲印第安人的慢性肾脏病知识和意识水平。 2) 确定由美国印第安人制作的计算机化数字故事的文化定制健康演示与传统健康视频演示相比的有效性，仅在试点临床干预试验中提高慢性肾脏病知识和被认为可预防慢性肾脏病或其进展的基线和后续因素。 总之，凭借这个 K23 奖项，Jolly 博士将能够将大部分时间和精力集中在职业发展和研究上，以获得高级培训并接受所需的关键指导。

DESCRIPTION (provided by applicant): Candidate. The overarching goal of this K23 award is to provide Dr. Stacey Jolly, an Alaska Native academic general internist, with the training, research skills, experience, and professional development to establish an independent program of chronic kidney disease-related research. Her proposed training program consists of three core components: (1) community based and translational research principles; (2) qualitative methods and survey design; and, (3) methodology, implementation, and evaluation of prospective clinical trials. She has proposed formal coursework, tutorials, and practical experience for each of the components. She will learn about and incorporate community based and translational research principles. She will develop new analytic skills in the area of qualitative and mixed methods research. She will learn how to translate rich qualitative data into quantitative approaches, specifically survey development. She will learn how to create culturally and content appropriate chronic kidney disease educational materials in the form of computerized digital stories made by American Indians. She will test this inventive modality in a pilot interventional trial with the aim of increasing chronic kidney disease knowledge and awareness and chronic kidney disease protective behaviors among American Indians, as well as assessing feasibility acceptability, and effect size. At the completion, she will be well suited to obtain independent research funding. Her career will advance not only as a physician researcher but in academic medicine as well moving from the Assistant to Associate Professor level. Environment. The Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, and its affiliate Case Western Reserve University are the major education and research facilities in Cleveland, OH. Dr. Jolly is an Assistant Professor of Medicine at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. She will benefit from a rich, multidisciplinary mentorship and training environment, which includes experts in nephrology, qualitative methods, public health, epidemiology, biostatistics, and health disparities research. Dr. Ashwini Sehgal is a Professor of Medicine at Case Western Reserve University and Principal Investigator of the Case Center for Reducing Health Disparities will serve as Dr. Jolly's primary mentor. Dr. Spero Manson is a Professor of Medicine at University of Colorado Denver and Principal Investigator of the Centers for American Indian and Alaska Native Health will serve as a co-mentor. Dr. Cheryl Killion is an Associate Professor of Nursing at Case Western Reserve University and qualitative methods expert will serve as a co-mentor. Dr. Jolly brings together a diverse mentorship team, consultants, and advisory committee members that offer extensive research experience, especially among American Indians, and support of her career development program. The site of her research project and data collection will be in South Dakota in which she will work closely with the Strong Heart Study Dakota Center run by Marcia O'Leary of Missouri Breaks Research Industries, Inc. The Strong Heart Study is a well established NIH/NHLBI funded study. Research Project. The goal of this project is to assess chronic kidney disease knowledge and awareness among American Indians in the Northern Plains who have metabolic syndrome. Prior work among the general population and some minority populations adversely affected by chronic kidney disease has shown low knowledge and awareness of the condition. To our knowledge, no study has examined in detail chronic kidney disease knowledge, awareness, and beliefs among American Indians. This study proposes to conduct a series of focus groups and create a chronic kidney disease knowledge and awareness survey. Few educational intervention clinical trials have been conducted among those at risk for or with early chronic kidney disease. To our knowledge none have used digital storytelling as a means to deliver the educational messaged and have been conducted among American Indians, a group with high prevalence of chronic kidney disease and end stage kidney disease. The aims of the research project are to: 1) Quantify levels of chronic kidney disease knowledge and awareness among American Indians with metabolic syndrome. 2) Determine the effectiveness of a culturally tailored health presentation with computerized digital stories made by American Indians compared to a conventional health video presentation only for improving chronic kidney disease knowledge and factors thought to be preventative of chronic kidney disease or its progression at baseline and follow-up in a pilot clinical intervention trial. In summary, with this K23 award, Dr. Jolly will be able to focus the majority of her time and effort on career development and research to acquire the advanced training and receive the critical mentorship needed.