University of Pennsylvania Diabetes Research Center

描述（由申请人提供）：宾夕法尼亚大学糖尿病研究中心（DRC）参与了三十多年前由NIDDK建立的全国性跨学科项目，旨在促进糖尿病和相关代谢疾病的研究。Penn DRC的使命是支持和开发成功的预防、治疗和治愈糖尿病的方法。Penn DRC位于宾夕法尼亚大学，由宾夕法尼亚大学管理，为110多名糖尿病研究人员提供服务，主要来自宾夕法尼亚大学佩雷尔曼医学院，也来自大学其他学院以及费城合作机构，包括托马斯杰斐逊大学，天普大学医学院，莫奈尔化学感官中心和Wistar研究所。宾夕法尼亚大学医学研究中心是高度互动和跨学科的，代表了许多基础科学和临床部门。Penn DRC的研究基地分为4个重点小组：1)β细胞生理学和病理学；2)胰岛素和其他激素的信号传导；3)肥胖;4)心血管代谢及并发症。宾夕法尼亚大学糖尿病研究中心以多种方式促进和支持糖尿病研究。六个生物医学研究核心促进宾夕法尼亚大学研究人员的工作：功能基因组学核心；胰岛细胞生物学核心；小鼠表型、生理和代谢核心；未及/生物标记的核心;转基因和嵌合小鼠核心；和病毒载体核心。普林斯顿大学区域代谢组学中心进一步促进了合作研究和新兴技术在糖尿病研究中的应用。三十多年来，一个非常成功的试点和可行性资助计划培养了新的研究人员，并促进了糖尿病研究的新举措。一个广泛而密集的浓缩计划组织了每周一次的糖尿病和内分泌学研究研讨会，特别活动，以及一年一度的春季糖尿病研讨会，所有这些都旨在加强宾夕法尼亚大学DRC研究人员的沟通和合作，同时使他们了解最新发现。宾夕法尼亚大学研究人员指导各个层次的受训者（本科生、博士前、博士后博士、医学博士和医学博士/博士组合）。D)，而浓缩计划为糖尿病研究培训提供了一个极好的环境。生物医学核心项目、试点和可行性资助项目以及强化项目由管理刚果民主共和国的行政部门进行协调和宣传。其组织结构包括主任和副主任、执行委员会、核心董事委员会以及外部和内部咨询委员会，其职能是使宾夕法尼亚大学刚果民主共和国的糖尿病相关研究处于生物医学科学的前沿。

DESCRIPTION (provided by applicant): The Penn Diabetes Research Center (DRC) participates in the nationwide interdisciplinary program established over three decades ago by the NIDDK to foster research in diabetes and related metabolic disorders. The mission of the Penn DRC is to support and develop successful approaches to the prevention, treatment, and cure of diabetes mellitus. Located at and administered by the University of Pennsylvania, the Penn DRC serves over 110 diabetes-oriented investigators, primarily from Penn's Perelman School of Medicine but also from other Schools within the University as well as collaborating Philadelphia institutions including Thomas Jefferson University, Temple University School of Medicine, the Monell Chemical Senses Center, and the Wistar Institute. The Penn DERC is highly interactive and interdisciplinary, representing many basic science and clinical departments. The Research Base of the Penn DRC is organized in 4 focus groups: 1) Beta Cell Physiology and Pathology; 2) Signaling by Insulin and Other Hormones; 3) Obesity; and 4) Cardiovascular Metabolism and Complications. The Penn DRC facilitates and supports diabetes research in a variety of ways. Six Biomedical Research Cores facilitate the work of Penn DRC investigators: Functional Genomics Core; Islet Cell Biology Core; Mouse Phenotyping, Physiology, and Metabolism Core; Radioimmunoassay/Biomarkers Core; Transgenic and Chimeric Mouse Core; and Viral Vector Core. Collaborative research and application of emerging technologies to diabetes investigation are further promoted by the Regional Metabolomic Core at Princeton. A Pilot and Feasibility Grant Program that has been highly successful for over three decades serves to nurture new investigators and to foster new initiatives in diabetes research. A broad and intensive Enrichment Program organizes weekly Diabetes and Endocrinology Research seminars, special events, and an annual Spring Diabetes Symposium, all designed to enhance communication and collaboration of Penn DRC investigators while keeping them abreast of the latest discoveries. Penn DRC investigators mentor trainees at every level (undergraduate, predoctoral, and post-doctoral Ph.D., M.D., and combined M.D. /Ph.D), and the Enrichment Program provides a superb environment for training in diabetes research. The Biomedical Cores, Pilot and Feasibility Grant Program, and Enrichment Program are coordinated and publicized by an Administrative Component that governs the DRC. Its organizational structure, including the Director and Associate Director, Executive Committee, Committee of Core Directors, and external as well as internal advisory boards, functions to maintain the diabetes-related research at the Penn DRC at the forefront of biomedical science.