Univ of Pennsyvania Diabetes Endocrinology Res Ctr

宾夕法尼亚大学糖尿病内分泌研究中心

• 批准号: 7980511
• 负责人: MITCHELL A. LAZAR
• 金额: $ 31.87万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-04 至 2011-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7980511
• 关键词: Area; Basic Science; Beta Cell; Biological Markers; Biomedical Research; Cardiovascular system; Cell physiology; Cellular biology; Clinical; Collaborations; Communication; Core Facility; Diabetes Mellitus; Doctor of Medicine; Doctor of Philosophy; Endocrine; Endocrinology; Environment; Facility Designs; Focus Groups; Fostering; Gene Targeting; Genomics; Grant; Hormones; Institution; Investigation; Islet Cell; Mentors; Metabolic; Metabolic Diseases; Metabolism; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Obesity; Pathology; Pennsylvania; Phenotype; Philadelphia; Physiology; Postdoctoral Fellow; Radioimmunoassay; Research; Research Personnel; Research Support; Research Training; Schools; Science; Scientist; Tissues; Training; Transgenic Organisms; Universities; Viral Vector; base; insulin signaling; medical schools; pre-doctoral; programs; symposium

DESCRIPTION, OVERALL (provided by applicant): The Penn Diabetes and Endocrinology Research Center (DERC) participates in the nationwide interdisciplinary program established nearly three decades ago by the NIDDK to foster research and training in the areas of diabetes and related endocrine and metabolic disorders. The Penn DERC is located at and administered by the University of Pennsylvania. It serves over 90 diabetes-oriented investigators primarily from the University of Pennsylvania, School of Medicine, but also from other Schools within the University of Pennsylvania as well as additional Philadelphia institutions including Jefferson and Temple. The Penn DERC is highly interactive and interdisciplinary, representing many basic science and clinical departments at Penn and the other institutions. The Research Base of the Penn DERC includes investigators organized in the following 4 focus groups: Beta Cell Physiology and Pathology; Signaling by Insulin and Other Hormones; Obesity and Metabolic Tissues; and Cardiovascular Metabolism and Complications. The Penn DERC facilitates and supports research in diabetes and endocrinology in a variety of ways. Six Biomedical Research Core facilities are designed to facilitate the inter-disciplinary investigations of Penn DERC scientists: Genomics and Gene Targeting Core; Islet Cell Biology Core, Mouse Phenotyping, Physiology, and Metabolism Core; Radioimmunoassay and Biomarkers Core; Transgenic and Chimeric Mouse Core, and Viral Vector Core. A Pilot and Feasibility Grant Program that has been extremely successful for over two decades serves to nurture new investigators in diabetes and to foster new initiatives in diabetes. An intensive Academic Enrichment Program organizes weekly Diabetes and Endocrinology Research seminars, monthly interdisciplinary and translational focus discussions, and an annual Diabetes Day symposium as well as other activities that facilitate communication and collaboration of Penn DERC investigators while keeping them abreast of the latest discoveries in diabetes and endocrinology. Penn DERC investigators mentor trainees at every level (undergraduate, pre-doctoral, and post-doctoral Ph.D., M.D., and combined M.D.,Ph.D), and the DERC academic activities provide a superb environment for training in diabetes research. An Administrative Component coordinates and publicizes the Biomedical Cores, Pilot and Feasibility Grant Program, and Academic Enrichment Program. These functions of the Penn DERC maintain the diabetes-related research program at this Center at the forefront of biomedical science.

总体描述（由申请人提供）： Penn Diabetes and Endocrinology Research Center（DERC）参与了近三十年前由NIDDK建立的全国性跨学科计划，以促进糖尿病和相关内分泌和代谢紊乱领域的研究和培训。宾夕法尼亚大学DERC位于宾夕法尼亚大学并由其管理。它为90多名糖尿病研究人员提供服务，主要来自宾夕法尼亚大学医学院，但也来自宾夕法尼亚大学的其他学校以及其他费城机构，包括杰斐逊和坦普尔。Penn DERC是高度互动和跨学科的，代表了Penn和其他机构的许多基础科学和临床部门。Penn DERC的研究基地包括以下4个重点小组的研究人员：β细胞生理学和病理学;胰岛素和其他激素的信号传导;肥胖和代谢组织;以及心血管代谢和并发症。Penn DERC以各种方式促进和支持糖尿病和内分泌学的研究。六个生物医学研究核心设施旨在促进Penn DERC科学家的跨学科研究：基因组学和基因靶向核心;胰岛细胞生物学核心，小鼠表型，生理学和代谢核心;放射免疫测定和生物标志物核心;转基因和嵌合小鼠核心，以及病毒载体核心。一个试点和可行性补助金计划，已经非常成功的二十多年来，有助于培养新的研究人员在糖尿病和促进新的举措在糖尿病。一个密集的学术充实计划组织每周糖尿病和内分泌学研究研讨会，每月跨学科和翻译重点讨论，以及年度糖尿病日研讨会以及其他活动，促进宾夕法尼亚州DERC研究人员的沟通和合作，同时让他们了解糖尿病和内分泌学的最新发现。宾夕法尼亚大学DERC研究人员指导各个层次的学员（本科，博士前和博士后博士，医学博士，和综合医学博士DERC的学术活动为糖尿病研究培训提供了极好的环境。一个行政部门协调和宣传生物医学核心，试点和可行性赠款计划，以及学术充实计划。Penn DERC的这些功能使该中心的糖尿病相关研究项目保持在生物医学科学的最前沿。