Univ of Pennsyvania Diabetes Endocrinology Res Ctr

总体描述(由申请人提供)： 宾夕法尼亚大学糖尿病和内分泌研究中心(DERC)参与了NIDDK在近30年前建立的全国性跨学科计划，该计划旨在促进糖尿病及相关内分泌和代谢紊乱领域的研究和培训。宾夕法尼亚大学DERC位于宾夕法尼亚大学，由宾夕法尼亚大学管理。它为90多名糖尿病研究人员提供服务，这些研究人员主要来自宾夕法尼亚大学医学院，但也来自宾夕法尼亚大学其他学院以及包括杰斐逊和坦普尔在内的其他费城机构。宾夕法尼亚大学DERC是高度互动和跨学科的，代表了宾夕法尼亚大学和其他机构的许多基础科学和临床部门。宾夕法尼亚大学DERC的研究基地包括以下4个重点小组的研究人员：β细胞生理学和病理学；胰岛素和其他激素的信号传递；肥胖和代谢组织；以及心血管代谢和并发症。宾夕法尼亚大学糖尿病和内分泌学研究中心以各种方式促进和支持糖尿病和内分泌学的研究。六个生物医学研究核心设施旨在促进宾夕法尼亚大学DERC科学家的跨学科研究：基因组学和基因打靶核心；胰岛细胞生物学核心、小鼠表型、生理学和代谢核心；放射免疫分析和生物标记物核心；转基因和嵌合小鼠核心；以及病毒载体核心。20多年来一直非常成功的试点和可行性补助计划有助于培养糖尿病领域的新研究人员，并促进糖尿病领域的新举措。强化学术充实计划每周组织糖尿病和内分泌学研究研讨会、每月跨学科和翻译焦点讨论、每年一次的糖尿病日研讨会以及其他活动，以促进宾夕法尼亚大学糖尿病和内分泌学研究人员的沟通和合作，同时使他们了解糖尿病和内分泌学的最新发现。宾夕法尼亚大学糖尿病研究中心的研究人员在各个层面(本科生、博士后和博士后)指导受训人员(本科、博士后、医学博士，以及医学博士和博士后)，该中心的学术活动为糖尿病研究方面的培训提供了一个极好的环境。一个行政部门协调和宣传生物医学核心、试点和可行性资助计划以及学术充实计划。宾夕法尼亚大学DERC的这些职能使该中心的糖尿病相关研究计划处于生物医学科学的前沿。

DESCRIPTION, OVERALL (provided by applicant): The Penn Diabetes and Endocrinology Research Center (DERC) participates in the nationwide interdisciplinary program established nearly three decades ago by the NIDDK to foster research and training in the areas of diabetes and related endocrine and metabolic disorders. The Penn DERC is located at and administered by the University of Pennsylvania. It serves over 90 diabetes-oriented investigators primarily from the University of Pennsylvania, School of Medicine, but also from other Schools within the University of Pennsylvania as well as additional Philadelphia institutions including Jefferson and Temple. The Penn DERC is highly interactive and interdisciplinary, representing many basic science and clinical departments at Penn and the other institutions. The Research Base of the Penn DERC includes investigators organized in the following 4 focus groups: Beta Cell Physiology and Pathology; Signaling by Insulin and Other Hormones; Obesity and Metabolic Tissues; and Cardiovascular Metabolism and Complications. The Penn DERC facilitates and supports research in diabetes and endocrinology in a variety of ways. Six Biomedical Research Core facilities are designed to facilitate the inter-disciplinary investigations of Penn DERC scientists: Genomics and Gene Targeting Core; Islet Cell Biology Core, Mouse Phenotyping, Physiology, and Metabolism Core; Radioimmunoassay and Biomarkers Core; Transgenic and Chimeric Mouse Core, and Viral Vector Core. A Pilot and Feasibility Grant Program that has been extremely successful for over two decades serves to nurture new investigators in diabetes and to foster new initiatives in diabetes. An intensive Academic Enrichment Program organizes weekly Diabetes and Endocrinology Research seminars, monthly interdisciplinary and translational focus discussions, and an annual Diabetes Day symposium as well as other activities that facilitate communication and collaboration of Penn DERC investigators while keeping them abreast of the latest discoveries in diabetes and endocrinology. Penn DERC investigators mentor trainees at every level (undergraduate, pre-doctoral, and post-doctoral Ph.D., M.D., and combined M.D.,Ph.D), and the DERC academic activities provide a superb environment for training in diabetes research. An Administrative Component coordinates and publicizes the Biomedical Cores, Pilot and Feasibility Grant Program, and Academic Enrichment Program. These functions of the Penn DERC maintain the diabetes-related research program at this Center at the forefront of biomedical science.