权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

WICER 4U

威瑟4U

基本信息

批准号：
8691256
负责人：
SUZANNE BAKKEN
金额：
$ 75万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2015-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8691256
关键词：
WICER 4U

项目摘要

DESCRIPTION (provided by applicant): The overall goals of the Washington Heights/Inwood Informatics Infrastructure for Comparative Effectiveness Research (WICER) were to gain a comprehensive understanding of the Washington Heights/Inwood (WHI) population, to facilitate research with this population, and to demonstrate WICER infrastructure capabilities for comparative effectiveness research/patient-centered outcomes research (CER/PCOR) for the significant clinical problem of hypertension. We engaged with WHI community member and CER/PCOR investigator stakeholders to accomplish these goals through collection of community-based surveys from more than 6,000 WHI community members; characterization of the WHI community in the New York-Presbyterian Columbia University Medical Center clinical data warehouse (NYP-CUMC CDW) and overlap among survey, NYP-CUMC CDW, and Visiting Nurse Service of New York data sources; design and implementation of a de-identified research data warehouse (RDW) and a user interface (Research Data Explorer [RedX]) for browsing RDW data; design and implementation of a scheduling system that integrates research and clinical tasks; conduct of three CER/PCOR studies, and establishment of data governance policies, structures, and processes to facilitate data access for CER/PCOR. Building upon the accomplishments of WICER, the specific aims of WICER 4 U are: 1. To apply principles of stakeholder engagement and a variety of methods to understand the needs of diverse stakeholders (CER/PCOR investigators, clinical transformation leaders, WHI community members, and WHI community-based organizations) and use this understanding to enhance the existing WICER data infrastructure. 2. To extend the existing WICER data infrastructure through a) collection of additional WICER survey data through the GetHealthyHeights web portal; b) linkage of biomarker data for a sub-group of WICER survey participants; c) linkage of DNA sample data for a sub-group of WICER survey participants; d) integration of population measures for WHI from population-based behavioral and environmental surveys; e) refinement and extension of RedX; and f) refinement and integration of a set of novel algorithms for the identification of matched controls for a given set of study cases, the quantification of potential confounding bias, and the inference of missing signals in the linked WICER data sets. 3. To assess the capability of the extended WICER data infrastructure to meet stakeholder needs through a) the conduct of pilot studies to assess bias, completeness, accuracy, and analytic utility of data in the linked WICER datasets for the clinical topics of hypertension and mental health; and b) the enhancement of the data governance policies, structures, and processes developed in WICER.

描述（由申请人提供）：华盛顿高地/因伍德比较有效性研究信息基础设施（WICER）的总体目标是全面了解华盛顿高地/因伍德（WHI）人群，促进对该人群的研究，并展示WICER基础设施在高血压这一重大临床问题的比较有效性研究/以患者为中心的结果研究（CER/PCOR）中的能力。我们与WHI社区成员和CER/PCOR调查员利益相关者合作，通过收集来自6,000多名WHI社区成员的社区调查来实现这些目标；纽约长老会哥伦比亚大学医学中心临床数据仓库（NYP-CUMC CDW）中WHI社区的特征以及纽约数据源中调查、NYP-CUMC CDW和探访护士服务的重叠；设计和实现一个去识别的研究数据仓库（RDW）和一个用户界面（研究数据浏览器[RedX]），用于浏览RDW数据；设计和实施整合研究和临床任务的调度系统；开展三项CER/PCOR研究，并建立数据治理政策、结构和流程，以促进CER/PCOR的数据访问。基于WICER的成就，WICER 4u的具体目标是：1。运用利益相关者参与原则和多种方法来了解不同利益相关者（CER/PCOR研究者、临床转化领导者、WHI社区成员和WHI社区组织）的需求，并利用这种理解来增强现有的WICER数据基础设施。2. 通过以下方式扩展现有的WICER数据基础设施：a)通过GetHealthyHeights门户网站收集额外的WICER调查数据；b) WICER调查参与者亚组的生物标志物数据链接；c) WICER调查参与者亚组的DNA样本数据链接；d)从基于人口的行为和环境调查中整合WHI的人口措施；e) RedX的细化和扩展；f)改进和整合一组新的算法，用于识别一组给定的研究案例的匹配对照，潜力的量化