Genetic variants associated with smallpox vaccine immune response heterogeneity

与天花疫苗免疫反应异质性相关的遗传变异

• 批准号: 8751441
• 负责人: GREGORY POLAND
• 金额: $ 199.68万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8751441
• 关键词: Affect; Alleles; Area; Biological Markers; Cells; Contractor; Contracts; Development; Diagnostic tests; Epigenetic Process; Genetic Polymorphism; Genetic Variation; Genotype; Goals; Heterogeneity; Human; Human Genetics; Immune; Immune response; Immunity; Individual; Infection; Infectious Agent; Knowledge; Lead; Mediating; Outcome; Phenotype; Population Genetics; Research; Risk; Risk Factors; Single Nucleotide Polymorphism; Smallpox; Smallpox Vaccine; Therapeutic; Time; Vaccinated; Vaccination; Vaccines; Variant; Work; cell mediated immune response; cohort; gene function; genetic analysis; genetic risk factor; genetic variant; human disease; interest; new technology; novel diagnostics; novel vaccines; pathogen; programs; response; transcriptomics

The Population Genetics Analysis program is focused on human genetic variation underlying differential immune responses to vaccination against or infection by human pathogens. The goals are to replicate previously identified human genotype-phenotype associations and elucidate the functional relevance of the validated genetic variants that correlate with immune outcome. Research will focus on one or more of the emerging or re-emerging Group I, II, or III infectious agents listed at http://www3.niaid.nih.gov/topics/emerging/list.htm. This information will help to identify individual risk factors, will expand our understanding of immune mechanisms applicable to a broad range of human diseases, and will help define biomarkers of risk and immunity that might lead to novel diagnostic tests of infection or vaccine response. This contract will study the genetic variants associated with smallpox vaccine immune response heterogeneity

群体遗传学分析项目的重点是人类遗传变异，这些变异是对人类病原体接种疫苗或感染的不同免疫反应的基础。目标是复制先前确定的人类基因型-表型关联，并阐明与免疫结果相关的经验证的遗传变异的功能相关性。研究将集中在http://www3.niaid.nih.gov/topics/emerging/list.htm上列出的一种或多种新出现或重新出现的I、II或III组传染性病原体。这些信息将有助于识别个体风险因素，将扩大我们对适用于广泛人类疾病的免疫机制的理解，并将有助于定义风险和免疫的生物标志物，这可能导致新的感染或疫苗反应的诊断测试。 该合同将研究与天花疫苗免疫反应异质性相关的遗传变异