Molecular Mechanisms of Immune Tolerance

我们请求支持一个博士后培训计划，重点是免疫学的分子机制， 耐受性和自身免疫。该应用程序是在开发集成的 免疫学系，其教师强烈关注B和T细胞发育，抗原 识别、库发育、通过编辑沉默、缺失和无反应性，以及理解 自身免疫免疫学综合系由56名教师组成（小学和 中学）从三个机构：国家犹太医学和研究中心（NJMRC），芭芭拉 戴维斯儿童糖尿病中心（BDC）和丹佛科罗拉多大学和健康科学 中心（UCDHSC）。自成立以来，21名培训教师中有近一半被招聘到该部。 成立于1999年，所有的培训教师都得到了NIH投资回报率赠款的支持，他们是校长 调查员我们请求为4名研究员提供津贴支持，他们将在自己选择的实验室接受培训。的 研究员将参加定期举办的期刊俱乐部、研究进展研讨会、正式研讨会、 和课程，例如关于科学中的伦理和生存技能的课程， 监督委员会（TOC）。受训人员将被任命为一年，只有在他们被评判后才能被重新任命 TOC取得了重大进展。我们的目标是为研究员提供全面的知识 免疫耐受和小鼠自身免疫模型，并充分了解临床 自身免疫，使他们能够发展生产性的临床合作关系，以翻译研究。 该计划主任是约翰坎比尔博士，艾达和塞西尔绿色教授和主席的综合 免疫学系。Cambier博士是B细胞信号传导、激活和无反应性方面的专家， 培训了60多名研究生和博士后研究员。该培训计划提供 一流的研究设施和教师，在培训和研究方面都是互动的。虽然丹佛 免疫学社区一直在培养前和博士后研究员超过30年，形成 免疫学综合系和新教师的聘用提供了一个强大的团结的影响， 为教育科研活动注入了新的活力。该培训计划是 这一活力的核心焦点。 相关性（参见说明）：

We request support for a postdoctoral training program focused on molecular mechanisms of immunologic tolerance and autoimmunity. This application comes on the heels of development of an Integrated Department of Immunology whose faculty is strongly focused on B and T cell development, antigen recognition, repertoire development, silencing by editing, deletion and anergy, and understanding autoimmunity. The Integrated Department of Immunology is comprised of 56 faculty (primary and secondary) from three institutions: the National Jewish Medical and Research Center (NJMRC), The Barbara Davis Center for Childhood Diabetes (BDC) and The University of Colorado at Denver and Health Sciences Center (UCDHSC). Nearly half of the 21 training faculty have been recruited to the Department since its inception in 1999, and all training faculty are supported by NIH ROI grants on which they are Principal Investigator. We request stipend support for 4 fellows who will train in laboratories of their choosing. The fellows will participate in regularly scheduled journal clubs, research in progress seminars, formal seminars and courses, e.g. on ethics and survival skills in science, and their progress will be monitored by a training oversight committee (TOC). Trainees will be appointed for one year and reappointed only if they are judged by the TOC to be making significant progress. Our goal is to provide fellows with comprehensive knowledge of immune tolerance and mouse models of autoimmunity, and sufficient understanding of clinical autoimmunity to enable their development of productive clinical collaborative ties for translation of research. The Program Director is Dr. John Cambier, Ida and Cecil Green Professor and Chairman ofthe Integrated Department of Immunology. Dr. Cambier is an expert in B cell signaling, activation and anergy, and has trained in excess of 60 graduate students and postdoctoral fellows. The training program has available superb research facilities and the faculty, are interactive in both training and research. Although the Denver immunology community has been training pre- and postdoctoral fellows for over 30 years, the formation of the Integrated Department of Immunology and hiring of new faculty has provided a strongly uniting influence, and injected new excitement and vitality into our educational and research activities. This training program is a central focus of that vitality. RELEVANCE (See instructions):