课题基金 / 基金详情

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells
HIV-1 进入并转移至 CD4 T 细胞的机制
批准号：
8745628
负责人：
John Mascola
金额：
$22.07万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8745628
关键词：
Animal ModelCD4 Positive T LymphocytesCell DeathCell SurvivalCellsCessation of lifeGoalsHIV InfectionsHIV-1Helper-Inducer T-LymphocyteHumanIndividualInfectionLeadMacacaModelingMolecularResearch DesignT-Cell DepletionT-LymphocyteTestingTherapeutic InterventionViralViral ProteinsViremiaVirusVirus Diseasescell killingimmune functionimprovedviral DNA

项目摘要

项目成果

John Mascola的其他基金

相关文献

中文摘要
翻译
过去一年的一个主要研究重点是继续在分子和细胞水平上更好地了解HIV-1诱导的细胞死亡，并在动物模型中测试治疗干预措施。该实验室继续对不同因素进行研究，以更好地了解HIV感染期间的T细胞死亡。这些研究的结果旨在帮助揭示和定义特定病毒基因产物和病毒感染背景下CD 4 T细胞耗竭的机制。
英文摘要
A major focus of study during the past year has been to continue to better understand HIV-1 induced cell death at the molecular and cellular levels and to test therapeutic interventions in animal models. The lab continued their ongoing studies of different factors to better understand T cell death during HIV infection. The results of these studies are designed to help uncover and define the mechanisms involved in CD4 T cell depletion by specific viral gene products and in the context of viral infection.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Next Generation Development of Broadly Neutralizing HIV Antibodies for Prevention
HIV/AIDS Vaccine and Antibody Development
Pre-clinical Vaccine Development for Respiratory Viruses
Pre-clinical Vaccine and Antibody Development for Coronavirus Disease 2019 (COVID-19)