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Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells

Mechanisms Of HIV-1 Entry and Transfer to CD4+ T cells
HIV-1 进入并转移至 CD4 T 细胞的机制
批准号：
8745628
负责人：
John Mascola
金额：
$22.07万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/8745628
关键词：
Animal ModelCD4 Positive T LymphocytesCell DeathCell SurvivalCellsCessation of lifeGoalsHIV InfectionsHIV-1Helper-Inducer T-LymphocyteHumanIndividualInfectionLeadMacacaModelingMolecularResearch DesignT-Cell DepletionT-LymphocyteTestingTherapeutic InterventionViralViral ProteinsViremiaVirusVirus Diseasescell killingimmune functionimprovedviral DNA

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中文摘要
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英文摘要
A major focus of study during the past year has been to continue to better understand HIV-1 induced cell death at the molecular and cellular levels and to test therapeutic interventions in animal models. The lab continued their ongoing studies of different factors to better understand T cell death during HIV infection. The results of these studies are designed to help uncover and define the mechanisms involved in CD4 T cell depletion by specific viral gene products and in the context of viral infection.
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