FASEB SRC on TGF beta Superfamily: Signaling in Development and Disease

描述（由申请人提供）：TGF-？超家族包含大量的分泌细胞因子，起源于有组织的多细胞生命在进化的开始。这些细胞间的信号蛋白调节了大量的发育、生理和体内平衡过程。最近大量的工作都是为了了解TGF-的分子机制。信号通路的异常导致发育异常和人类疾病病理。这次会议有三个主要目标。首先是提供一个关于分子和细胞水平上信号转导机制的整合生化知识的场所，系统方法旨在描述这些因素如何协调发育过程并促进各种人类疾病状态，包括癌症，心血管和代谢紊乱以及肌肉骨骼和神经系统病变。为了实现这一目标，我们将开展多样化的互动活动，包括按主题组织的会谈和海报会议，所有这些活动都将在一个私密的环境中举行，参与者人数有限。我们邀请了广泛的专家，涵盖了TGF-的各种生物学作用的所有关键和新兴方面。家庭成员。这次会议的第二个目标是帮助年轻的科学家、少数民族和妇女融入这个不断发展的领域，并激励他们引领未来的创新和发现。创建非正式和创造性论坛的第三个目标也是密切相关的

DESCRIPTION (provided by applicant): The TGF-? superfamily encompasses a large number of secreted cytokines that originated at the onset of organized multi-cellular life in evolution. These cell-to-cell signaling proteins regulate an extensive number of developmental, physiological and homeostatic processes. A great deal of recent work has gone into understanding the molecular mechanisms of TGF-?? signaling and the way in which aberrations in this signaling pathway lead to developmental abnormalities and human disease pathologies. There are three primary objectives of this conference. The first is to offer a venue for integratin biochemical knowledge about signal transduction mechanisms at the molecular and cellular level, with systems approaches that aim to describe how these factors coordinate developmental processes and contribute to various human disease states, including, cancer, cardiovascular and metabolic disorders and musculoskeletal and nervous system pathologies. We will accomplish this goal through a diverse and interactive program of talks and poster sessions, organized by theme, and all held in an intimate setting with a limited number of participants. We have invited a wide spectrum of specialists that cover all the key and emerging aspects of the diverse biological roles of TGF-?? family members. A second goal for this conference is to help younger scientists, minorities and women integrate to this ever-increasing field and stimulate them to lead the way for the future steps of innovation and discovery. Intimately intertwined is also the third objective of creating the informal and creative forum that continuously seeds the fertile soil for building national and international collaborations, especially between experts working on complementary themes, for example biochemists with embryologists and stem cell biologists with clinically oriented researchers. This productive environment has in the past, and will even further now, contributed to the generation of more systemic approaches to the signaling networks, their biological underpinnings and the means to exploit them diagnostically and in the development of therapy. Our collective experience that has been built over six previous conferences with the same goals provides us with the strong confidence that our objectives will be met and will pave the way to the propagation of this successful field.