Interdisciplinary Research Training in Cancer Biology

描述(由申请者提供)：这个多学科的项目将重点培训癌症生物学的博士后研究生和博士后研究员，使他们能够有效地破译与人类癌症相关的重要研究问题。为了实现这一目标，我们将在信号转导和癌细胞存活机制、癌症进展和转移、肿瘤微环境、氧化应激和DNA损伤与临床暴露方面已经建立和成功的计划整合到一个连贯的计划中。学员将接受授课和非授课指导、以实验室为基础的基础科学研究培训、癌症研究和前沿临床应用方面的培训，以及作为独立癌症生物学家的职业发展。学生和研究员将接受充分的培训，以阐明他们的想法并有效地进行沟通，评估生物医学研究，并在科学方面指导其他人，从而发挥科学界重要成员的作用。这一计划汇集了来自医学院6个不同系的基础科学和临床教师的凝聚力。在过去的10年里，我们的项目教员已经培训了90名博士生和100多名博士后研究员，并拥有经验和跨学科的重点来指导这群受训人员在从事多学科研究的研究团队中发挥作用。我们指导我们的学员熟练地利用假设驱动的方法以及以发现为导向的研究设计来解决关键问题。所有学员都必须完成研究生级别的遗传学、生物化学、免疫学、药理学、生理学、细胞生物学、分子生物学、生物统计学、伦理学的基础课程，以及癌症生物学和治疗课程，该课程强调人类疾病中的癌症。培训还包括参加Markey癌症中心研讨会系列和癌症生物学杂志俱乐部。这一计划的一个独特之处是跨学科培训机会，将强调从工作台到床边(反之亦然)的研究主题，以提供癌症基础生物学和临床癌症之间的桥梁。最终目标是培养一批未来的科学家，他们可以成为综合团队方法的领导者，了解癌症的复杂问题，因为它与潜在的预防和治疗策略有关。此外，为了帮助确保我们致力于基础科学发现的临床转化，Markey癌症中心副主任Vivek Rangnekar博士和Mark Ever医学博士主任将担任这一基于团队的培训计划的PI。肯塔基大学非常重视对少数民族学生、博士后研究人员和医生的培训，因此，该项目将确保纳入种族和民族背景不足的个人，以更好地服务于我们多样化的社会。因此，该培训计划将培训下一代癌症研究人员，以使用跨学科团队的方法更好地理解和治疗癌症。

DESCRIPTION (provided by applicant): This multi-disciplinary program will focus on training pre-doctoral students and post-doctoral fellows in Cancer Biology so that they can effectively decipher important research questions associated with human Cancer. To accomplish this objective, we have integrated the already established and successful programs in Signal Transduction and Mechanisms of Cancer Cell Survival, Cancer Progression and Metastasis, Tumor Microenvironment, and Oxidative Stress and DNA Damage with clinical exposure into one cohesive program. The trainees will receive both didactic and non-didactic instruction, laboratory-based basic science research training in cancer research and cutting edge clinical applications, and career development as independent cancer biologists. The students and fellows will receive ample training to articulate their ideas and communicate them effectively, evaluate biomedical research, and mentor others in scientific excellence, and thus function as important members of the scientific community. This program assembles a cohesive group of basic science and clinical faculty from 6 different departments at the College of Medicine. In the past 10 years our program faculty has trained 90 doctoral students and over 100 post-doctoral fellows, and has the experience and the interdisciplinary focus to guide this group of trainees to function in research teams pursuing multidisciplinary investigations. We mentor our trainees to be proficient at utilizing hypothesis-driven approaches as well as discovery-oriented research design to address key problems. All trainees are required to complete the foundation courses in graduate level Genetics, Biochemistry, Immunology, Pharmacology, Physiology, Cell Biology, Molecular Biology, Biostatistics, Ethics, and the Cancer Biology and Therapy course, which emphasizes cancer in the context of human disease. Training also involves participation in the Markey Cancer Center Seminar Series and a Cancer Biology Journal Club. A unique feature of this program is the interdisciplinary training opportunity that will emphasize bench to bedside (and vice versa) research topics to provide a bridge between the fundamental biology of cancer and clinical cancer. The ultimate objective is to develop a cadre of future scientists who can become leaders in integrative team approaches to understand the complex issue of cancer as it relates to potential prevention and treatment strategies. Moreover, to help ensure our commitment to the clinical-translation of basic science discoveries, Markey Cancer Center Associate Director Vivek Rangnekar, Ph.D. and Director Mark Evers, M.D., will be PIs for this team-based training program. The University of Kentucky places a significant emphasis on training of minority students, post-doctoral researchers and physicians, and therefore this program will ensure the inclusion of individuals with under-represented racial and ethnic background to better serve our diverse society. Accordingly, this training program will train the next generation of cancer researchers to better understand and treat cancers using an interdisciplinary team approach.