Hawaiian, Asian American, and Pacific Islander (HAAPI) Coordinating Center

夏威夷、亚裔美国人和太平洋岛民 (HAAPI) 协调中心

• 批准号: 10724999
• 负责人: GARNET L. ANDERSON
• 金额: $ 260万
• 依托单位: FRED HUTCHINSON CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-15 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10724999
• 关键词: Address; Ancillary Study; Asian; Asian Americans; Asian population; Behavioral Sciences; Biological; Biometry; Brain imaging; Cardiovascular Diseases; Cardiovascular system; Clinical; Communities; Data; Data Collection; Data Linkages; Data Science; Data Sources; Environment; Etiology; Funding; Generations; Genetic; Genomics; Goals; Hawaiian; Hawaiian population; Health; Heterogeneity; Immigrant; Immigration; Individual; Infrastructure; International; Knowledge; Laboratories; Leadership; Learning; Life Style; Medicine; Mental Health; Mental disorders; Mentors; Metabolic; Metabolic Diseases; Methods; Minority; National origin; Native Hawaiian or Other Pacific Islander; Neighborhoods; Outcome; Pacific Islander; Pacific Islands; Physical assessment; Population; Prevalence; Prospective, cohort study; Proteomics; Research; Research Personnel; Resources; Risk Factors; Science; Sociology; Source; Stereotyping; Stress; Time; United States National Institutes of Health; biobank; cardiovascular disorder epidemiology; cardiovascular risk factor; career development; climate change; cohort; community engagement; epidemiology study; experience; heart imaging; insight; mHealth; metabolomics; microbiome; next generation; novel; nutritional epidemiology; physical conditioning; population based; programs; prospective; recruit; social health determinants; wearable device

SUMMARY/ABSTRACT People of Asian, Hawaiian, or Pacific Islander (AsA-NHPI) ancestry, while representing 7.7% of the US population, have been largely underrepresented from NIH-funded prospective epidemiologic studies. As a result, there are large gaps in our knowledge of the burden and causes of cardiovascular, metabolic, and mental health disorders in these populations. Individuals of these backgrounds have experienced, to varying degrees, the barriers, stresses, and stereotyping experienced by other minorities while also having challenges that are unique to them. Understanding the heterogeneity of their lifestyles and societal and environmental circumstances, as well as their ancestry, is a critical first step in determining their health needs and how to address them. The heterogeneity in these populations, followed longitudinally and contrasted with other populations, may add unique insights into the etiology of both physical and mental health conditions. In this application for the Hawaiian, Asian American, and Pacific Islander Coordinating Center (HAAPI-CC), we propose to: (1) Bring exceptional scientific, statistical, and cultural expertise to the effort of assessing the physical and mental health and their determinants in people of Hawaiian, Asian, and Pacific Islander ancestry; (2) Provide the operational, data science, and biorepository infrastructure and leadership to support the scientific priorities of the cohort and stimulate and enhance ancillary study opportunities broadly; (3) Coordinate and support Clinical or Community Field Center (CCFC) activities to enhance recruitment and retention and broader community engagement; and (4) Enhance career development of early stage investigators, particularly those from under-represented backgrounds. Through this effort, we can estimate the prevalence of cardiovascular diseases and risk factors and mental health conditions, study their interplay and trajectories over time, and examine associations with novel exposures derived from data linkages and biospecimens. We anticipate leading a number of ancillary studies to obtain additional rich data from novel sources (wearables, mHealth, genomics, proteomics, metabolomics, microbiome, cardiac and brain imaging). Through these efforts, we and our CCFC colleagues, will advance the knowledge of the health conditions of Asian, Hawaiian, and Pacific Islanders and provide the infrastructure for deeper understanding of their biological, environmental, and sociological underpinnings. ,

摘要/摘要 亚洲人，夏威夷人或太平洋岛民（ASA-NHPI）血统，而代表美国7.7％ 人口在很大程度上受到了NIH资助的前瞻性流行病学研究的代表性不足。作为 结果，我们对心血管，代谢和原因的负担和原因的了解很大 这些人群中的心理健康障碍。这些背景的个人已经经历过 其他少数民族经历的学位，障碍，压力和刻板印象，同时也面临挑战 这是他们所独有的。了解其生活方式的异质性以及社会和环境 环境以及他们的祖先，是确定其健康需求以及如何确定其健康需求的关键第一步 解决他们。这些人群中的异质性，遵循纵向并与其他人形成鲜明对比 人群可能会为身心健康的病因增加独特的见解。在这个 夏威夷，亚裔美国人和太平洋岛民协调中心（HAAPI-CC）申请，我们 提议：（1）将卓越的科学，统计和文化专业知识带入评估 身心健康及其在夏威夷，亚洲和太平洋岛民血统的人中的决定因素； （2）提供运营，数据科学和生物座位基础架构和领导才能 队列的科学重点，并刺激和增强辅助研究机会； （3） 协调和支持临床或社区现场中心（CCFC）活动，以增强招聘和 保留和更广泛的社区参与； （4）增强早期职业发展 调查人员，特别是来自代表性不足的背景的研究人员。通过这项努力，我们可以估计 心血管疾病和危险因素以及心理健康状况的患病率，研究其相互作用和 随着时间的流逝，轨迹，并检查与来自数据链接的新型暴露和 生物测量。我们预计将带领许多辅助研究从新颖的 来源（可穿戴，MHealth，基因组学，蛋白质组学，代谢组学，微生物组，心脏和脑成像）。 通过这些努力，我们和我们的CCFC同事将促进有关健康状况的了解 亚洲，夏威夷人和太平洋岛民，并提供基础设施，以更深入地理解他们的 生物学，环境和社会学基础。 ，，，，