权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Flexible Statistical Methods for Complex Survival Data in Biomedical Studies

生物医学研究中复杂生存数据的灵活统计方法

基本信息

批准号：
8448221
负责人：
Wenbin Lu
金额：
$ 18.61万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-04-01 至 2016-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8448221
关键词：
Address Admixture Algorithms Arsenic Clinical Research Clinical Trials Cohort Studies Complement Complex Computer software Cox Proportional Hazards Models Data Data Analyses Data Set Development Disease Epidemiologic Studies Equation Etiology Event Failure Goals Health Human Lead Least-Squares Analysis Linear Regressions Literature Log-Linear Models Longitudinal Studies Medical Methodology Methods Modeling Nested Case-Control Study New York Performance Play Population Probability Procedures Property Publishing Research Research Design Research Personnel Research Project Grants Role Sampling Scientist Specific qualifier value Statistical Methods Statistical Models Structure Survival Analysis Technology Testing Theoretical Studies Time Universities Weight Women&apos s Health Work base case control cohort design disorder prevention expectation flexibility hazard improved innovation interest novel outcome forecast public health relevance research and development simulation sound theories tool treatment strategy

项目摘要

DESCRIPTION (provided by applicant): The broad, long-term objectives of this research are the developments of new statistical methodology for the analysis of survival data from both epidemiological studies and clinical trials. Significant progress has been made in statistical modeling and inference in survival data analysis; however, there are still many open questions and emerging challenges posed by new study designs, advanced technologies, as well as the growing scale and complexity of medical studies. In this proposed research, we will explore two general classes of semiparametric models, the transformation model and the accelerated failure time model, for analyzing complex survival data. These models not only are complements to Cox's proportional hazards model, but also provide general regression frameworks and possibly better strategies for modeling survival data. Thus, they play important roles in many biomedical applications by offering comprehensive survival analysis. We seek to develop statistically sound methods that not only make proper use of data information and structure but also are powerful and computationally efficient. Motivated by problems arising from the investigators' collaborative work on the New York University Women's Health Study (NYUWHS) and the Health Effects of Arsenic Longitudinal Study (HEALS), our methodology developments include the following four specific aims: (1.) To explore a broad class of linear transformation models in nested case-control (NCC) studies; (2.) To investigate efficient estimation of the accelerated failure time (AFT) model in case-cohort (CC) and nested case-control studies through a unified likelihood-based approach; (3.) To develop semiparametric Bayesian inference methods for the AFT cure model for the analysis of survival data from cohort studies or clinical trials in an admixture population with susceptible and non-susceptible (cured) subjects; (4.) To study partially linear regression modeling and the associated inference procedures for censored survival data from cohort studies or clinical trials. Results from the proposed project will be relevant and applicable to many biomedical studies. In all the specific aims, we will study the theoretical properties of the proposed estimators, and develop reliable numerical algorithms for implementing the proposed estimation methods. Special effort will also be devoted to developing and disseminating software for practitioners. We will carry out extensive simulation studies to evaluate relevance of the theory and the finite sample performance of the proposed estimators. We will also investigate the performance of the proposed methods on published datasets, compare them with existing approaches and demonstrate their applications in major clinical and epidemiological studies, including the NYUWHS and the HEALS. 1

描述(由申请人提供)：这项研究的广泛、长期目标是开发新的统计方法，用于分析流行病学研究和临床试验的生存数据。在生存数据分析的统计建模和推断方面取得了重大进展；然而，新的研究设计、先进的技术以及不断增长的规模和复杂性的医学研究仍然提出了许多悬而未决的问题和新的挑战。在这项拟议的研究中，我们将探索两类一般的半参数模型，即转换模型和加速失效时间模型，用于分析复杂的生存数据。这些模型不仅是对考克斯比例风险模型的补充，而且还提供了通用的回归框架和可能更好的生存数据建模策略。因此，通过提供全面的生存分析，它们在许多生物医学应用中扮演着重要的角色。我们寻求开发统计上可靠的方法，这些方法不仅适当地利用数据、信息和结构，而且功能强大，计算效率高。由于纽约大学妇女健康研究(NYUWHS)和砷纵向研究对健康的影响(HeALS)的研究人员共同工作中出现的问题，我们的方法学发展包括以下四个具体目标：(1)探索巢式病例对照研究中广泛的线性变换模型；通过统一的似然方法研究病例队列(CC)和嵌套病例对照研究中加速失效时间(AFT)模型的有效估计；开发AFT治愈模型的半参数贝叶斯推断方法，用于分析来自队列研究或临床试验的生存数据，这些数据来自混合人群中的易感和非易感(治愈)受试者；研究来自队列研究或临床试验的删失生存数据的部分线性回归模型和相关推断程序。拟议项目的结果将相关并适用于许多生物医学研究。在所有的具体目标中，我们将研究所提出的估计器的理论性质，并开发可靠的数值算法来实现所提出的估计方法。还将特别努力为从业人员开发和传播软件。我们将进行广泛的模拟研究，以评估理论的相关性和所提出的估计器的有限样本性能。我们还将在已发表的数据集上调查建议方法的性能，将它们与现有方法进行比较，并展示它们在主要临床和流行病学研究中的应用，包括NYUWHS和HEALS。1