Pain and Well-being in Older Women: The Roles of Activity and Motivation

老年女性的疼痛和健康：活动和动机的作用

• 批准号: 8532595
• 负责人: Leslie J Crofford
• 金额: $ 49.17万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8532595
• 关键词: Adverse effects; Affect; Age; Aging; Area; Arthritis; Back Pain; Biological Markers; Elderly; Feeling; Female; Genetic Polymorphism; Genotype; Goals; Guilt; Headache; Health; High Prevalence; Hydrocortisone; Individual; Individual Differences; Inflammation; Interleukin 6 Receptor; Interleukin-6; Link; Literature; Longitudinal Studies; Measures; Modeling; Moods; Motivation; Musculoskeletal Pain; Neurosecretory Systems; Outcome; Pain; Pain interference; Pain management; Patients; Personal Satisfaction; Personality; Persons; Physical activity; Physiological; Physiology; Prevalence; Prevalence Study; Recruitment Activity; Registries; Relative (related person); Reporting; Role; Sensory; Severities; Testing; Time; Woman; aged; chronic pain; diaries; experience; fitness; heart rate variability; hedonic; improved; interest; older women; optimism; physical conditioning; prognostic; psychologic; psychosocial; public health relevance; receptor; resilience; satisfaction; sex; social

DESCRIPTION (provided by applicant): The prevalence of chronic pain in older adults is high, and prevalence increases with increasing age. Although adverse effects of pain on hedonic well-being (HWB) are well documented, there is less evidence that pain has a direct effect on aspects of eudaemonic well-being (EWB) such as autonomy and social satisfaction. Evidence suggests that some older adults with high physical pain nonetheless maintain high EWB, whereas others with low physical pain have low EWB. The present study tests a model in which qualities of the goal-directed and physical activities of older women determine whether and how pain affects EWB. When activity is externally motivated by guilt or control, pain will inhibit activity and activity will adversely affect EWB; when activity is autonomously motivated by interest or self-definition, pain will not inhibit activity and activity will enhance EWB. Furthermore, when activities are accorded more time, these effects will be stronger. A second aim tests effects of activity and EWB on biomarkers, including diurnal cortisol and inflammation as measured by interleukin-6 and its soluble receptor. A third aim will test these relationships controlling for individual differences in personality, genotype, fitness, and pain sensitivity. Oldr women (N = 300, aged 50-75) with varying levels of pain will be recruited from an existing registry to complete 7-day diary periods at 3-month intervals over 9 waves to test day-, wave-, and person-level relationships. Daily measures will include goal-directed and physical activities (including motivation for and time spent in the activities), cortisol slope, subjective health, pai, pain interference, HWB, and psychological need satisfaction as a measure of day-level EWB. Wave-level measures will include the Scales of Psychological Well-Being, HWB, interleukin-6, and interleukin-6 receptor. Person-level measures will include optimism, COMT polymorphism, VO2max, and sensory testing. Multi-level modeling will test for between-person and within-person relationships and lagged effects. The co-PIs bring expertise in pain, goals, well-being, and physiology to these aims and have successfully completed longitudinal studies of older adults and pain patients, including a diary study. The study will advance understanding of how a common, age-relevant experience - physical pain - affects EWB and physical health.

描述（由申请人提供）：老年人慢性疼痛的患病率很高，并且患病率随着年龄的增长而增加。尽管疼痛对享乐福利（HWB）的不利影响已经有充分的文献记录，但较少的证据表明疼痛对eudaemonic福祉（EWB）的方面（例如自治和社会满意度）具有直接影响。有证据表明，一些身体疼痛高的老年人仍然保持高EWB，而其他身体疼痛低的老年人则具有低EWB。本研究测试了一个模型，在该模型中，老年妇女的目标定向和体育活动的品质决定了疼痛是否影响EWB。当活动受到内gui或控制动机时，疼痛会抑制活性，活动会对EWB产生不利影响。当活动是由兴趣或自我定义自主动机时，疼痛不会抑制活性，并且活性会增强EWB。此外，当活动获得更多时间时，这些效果将会更强。第二个目标测试活性和EWB对生物标志物的影响，包括白介素-6及其可溶性受体测量的昼夜皮质醇和炎症。第三个目标将测试这些关系，以控制人格，基因型，健身和疼痛敏感性的个体差异。老妇（n = 300，年龄50-75岁）将从现有注册表中招募不同程度的疼痛，以在9天的时间间隔内以9天的间隔在9天的时间内完成日记，以测试日，波浪，波浪和人级关系。每日措施将包括目标定向和体育活动（包括活动的动机和时间），皮质醇斜率，主观健康，PAI，疼痛干扰，HWB以及心理需求满意度，以衡量日级EWB的量度。波级测量方法将包括心理健康，HWB，白介素-6和白介素-6受体的尺度。人级措施将包括乐观，COMT多态性，VO2MAX和感觉测试。多级建模将测试人际关系和人际关系的关系以及滞后效应。 Co-Pis为这些目的带来了疼痛，目标，福祉和生理学方面的专业知识，并成功完成了对老年人和疼痛患者的纵向研究，包括日记研究。这项研究将促进对常见的，年龄与年龄相关的体验 - 身体疼痛 - 影响EWB和身体健康的理解。