Fibromyalgia Activity Study with TENS "FAST"
使用 TENS“FAST”进行纤维肌痛活动研究
基本信息
- 批准号:8903698
- 负责人:
- 金额:$ 70.26万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-01 至 2016-06-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAerobic ExerciseAmericanAnalgesicsBasic ScienceBrain StemChronicClinicalClinical TrialsDegenerative polyarthritisEffectivenessElectric StimulationExerciseFatigueFibromyalgiaFrequenciesFrightHealth ProfessionalHome environmentIndividualInterventionLaboratoriesMalaiseMeasuresMidbrain structureModalityMovementMuscleMusculoskeletal PainNeuraxisNeuronsNociceptionOutcomeOutcome MeasurePainPain ThresholdPain managementPathway interactionsPatientsPerformancePersonsPharmaceutical PreparationsPhysical FunctionPhysical activityPhysiologicalPhysiologyPlacebosPopulationPostoperative PainProcessQuality of lifeQuestionnairesRestRheumatologySkinSocial WorkSpinal CordSymptomsSyndromeTestingTranscutaneous Electric Nerve StimulationTranslatingUnited States Food and Drug AdministrationWalkingWomanWorkcollegedaily functioningdiffuse noxious inhibitory controldouble-blind placebo controlled trialefficacy testingfitnessimprovedimproved functioninginnovationinstrumentmenpain inhibitionpatient populationpublic health relevancestandard caretrial design
项目摘要
DESCRIPTION (provided by applicant): Pain associated with fibromyalgia interferes with daily function, work, and social activities resulting in a decreased quality of life. People with fibromyalgia also have a significant amount fatigue and a fear of movement. People with fibromyalgia show enhanced excitability of pain neurons in the central nervous system and reduced pain inhibition. Therefore, one of the main treatments for patients with fibromyalgia must focus on pain relief to allow the person to function more independently both at home and at work. Transcutaneous electrical nerve stimulation (TENS) is used by health professionals to deliver electrical stimulation through the skin for pain control. Basic science studies, from the PIs laboratory, show that TENS activates descending pain inhibitory pathways to inhibit excitability of pain neurons. Thus, the ideal patient population for the treatment of TENS would be one in which there is enhanced central excitability and reduced inhibition; fibromyalgia is such a condition. We hypothesize that application of TENS to patients with fibromyalgia will reduce movement-related pain and reduce central excitability by restoring central inhibition, and that this decrease in pain and/or central excitability will reduce fatigue and fear of movement, thereby improving function and quality of life. We will test this hypothesis through 4 Specific Aims. Aim 1: test the effectiveness of repeated use of TENS on movement-related pain in people with fibromyalgia with random assignment to three treatments: standard care, placebo TENS and active TENS. Aim 2: test if pain reduction by TENS results in a concomitant decrease in fatigue and fear of movement, and an increase in function and quality of life. Outcome measures will include physical function by directly assessing daily activity with an accelerometer, as well as performing specific functional tasks. Aim 3: determine if active TENS alters pain processing in people with fibromyalgia and if improvement in clinical symptoms correlates with normalization of pain processing physiology. We will evaluate change in these physiologic parameters in responders versus non-responders as assessed clinically. Aim 4: determine if PROMIS is a useful outcome for fibromyalgia by comparing to the revised version of the fibromyalgia impact questionnaire (FIQ-R).
描述(由申请人提供):与纤维肌痛相关的疼痛干扰日常功能、工作和社会活动,导致生活质量下降。患有纤维肌痛的人也有大量的疲劳和对运动的恐惧。纤维肌痛患者表现出中枢神经系统疼痛神经元的兴奋性增强和疼痛抑制减少。因此,纤维肌痛患者的主要治疗方法之一必须侧重于缓解疼痛,以使患者在家庭和工作中更独立地发挥作用。经皮电神经刺激(TENS)由健康专业人员使用,通过皮肤提供电刺激以控制疼痛。来自PI实验室的基础科学研究表明,TENS激活下行疼痛抑制通路以抑制疼痛神经元的兴奋性。因此,治疗TENS的理想患者人群是中枢兴奋性增强和抑制性降低的人群;纤维肌痛就是这样一种情况。我们假设,对纤维肌痛患者应用TENS将减少运动相关疼痛,并通过恢复中枢抑制来降低中枢兴奋性,并且这种疼痛和/或中枢兴奋性的降低将减少疲劳和对运动的恐惧,从而改善功能和生活质量。我们将通过四个具体目标来验证这一假设。目标1:测试重复使用TENS对纤维肌痛患者运动相关疼痛的有效性,随机分配三种治疗:标准治疗,安慰剂TENS和活性TENS。目标二:测试通过TENS减轻疼痛是否会导致疲劳和运动恐惧的伴随减少,以及功能和生活质量的增加。结果测量将包括通过使用加速度计直接评估日常活动的身体功能,以及执行特定的功能任务。目标3:确定主动TENS是否会改变纤维肌痛患者的疼痛处理过程,以及临床症状的改善是否与疼痛处理生理学的正常化相关。我们将根据临床评估,评价应答者与非应答者的这些生理参数的变化。目的4:通过与修订版纤维肌痛影响问卷(FIQ-R)进行比较,确定PROMIS是否是纤维肌痛的有用结局。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Leslie J Crofford其他文献
Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary-adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis.
白细胞介素 (IL)-6 与下丘脑-垂体-肾上腺轴激素之间的昼夜关系:IL-6 未能导致早期未经治疗的类风湿性关节炎患者持续皮质醇增多症。
- DOI:
10.1210/jcem.82.4.3852 - 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
Leslie J Crofford;K. Kalogeras;George Mastorakos;M. Magiakou;Jana Wells;Keith S. Kanik;P. W. Gold;G. P. Chrousos;Ronald L. Wilder - 通讯作者:
Ronald L. Wilder
The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome
- DOI:
10.1007/s003930050239 - 发表时间:
1998 - 期刊:
- 影响因子:0
- 作者:
Leslie J Crofford - 通讯作者:
Leslie J Crofford
Primer on the Rheumatic Diseases
风湿病入门
- DOI:
10.1001/jama.1953.63690040007008 - 发表时间:
1999 - 期刊:
- 影响因子:0
- 作者:
J. Klippel;John H. Stone;Leslie J Crofford;Patience H. White - 通讯作者:
Patience H. White
Do infectious agents cause rheumatoid arthritis?
传染源会引起类风湿性关节炎吗?
- DOI:
- 发表时间:
1991 - 期刊:
- 影响因子:4.2
- 作者:
Ronald L. Wilder;Leslie J Crofford - 通讯作者:
Leslie J Crofford
The neuroscience and endocrinology of fibromyalgia.
纤维肌痛的神经科学和内分泌学。
- DOI:
- 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
S. Pillemer;Laurence A. Bradley;Leslie J Crofford;Harvey Moldofsky;G. P. Chrousos - 通讯作者:
G. P. Chrousos
Leslie J Crofford的其他文献
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{{ truncateString('Leslie J Crofford', 18)}}的其他基金
Fibromyalgia TENS in Physical Therapy Study (TIPS): an embedded pragmatic clinical trial
纤维肌痛 TENS 物理治疗研究 (TIPS):一项嵌入式实用临床试验
- 批准号:
10891041 - 财政年份:2023
- 资助金额:
$ 70.26万 - 项目类别:
Fibromyalgia TENS in Physical Therapy Study (TIPS):an embedded pragmatic clinical trial
纤维肌痛 TENS 物理治疗研究 (TIPS):一项嵌入式实用临床试验
- 批准号:
10701211 - 财政年份:2019
- 资助金额:
$ 70.26万 - 项目类别:
Fibromyalgia TENS in Physical Therapy Study (TIPS):an embedded pragmatic clinical trial
纤维肌痛 TENS 物理治疗研究 (TIPS):一项嵌入式实用临床试验
- 批准号:
10253306 - 财政年份:2019
- 资助金额:
$ 70.26万 - 项目类别:
Fibromyalgia TENS in Physical Therapy Study (TIPS): an embedded pragmatic clinical trial: Administrative Supplement
物理治疗研究 (TIPS) 中的纤维肌痛 TENS:一项嵌入式实用临床试验:行政补充
- 批准号:
10650569 - 财政年份:2019
- 资助金额:
$ 70.26万 - 项目类别:
Pain and Well-being in Older Women: The Roles of Activity and Motivation
老年女性的疼痛和健康:活动和动机的作用
- 批准号:
8532595 - 财政年份:2013
- 资助金额:
$ 70.26万 - 项目类别:
Pain and Well-being in Older Women: The Roles of Activity and Motivation
老年女性的疼痛和健康:活动和动机的作用
- 批准号:
8685860 - 财政年份:2013
- 资助金额:
$ 70.26万 - 项目类别:
Fibromyalgia Activity Study with TENS "FAST"
使用 TENS“FAST”进行纤维肌痛活动研究
- 批准号:
8652437 - 财政年份:2013
- 资助金额:
$ 70.26万 - 项目类别:
Fibromyalgia Activity Study with TENS "FAST"
使用 TENS“FAST”进行纤维肌痛活动研究
- 批准号:
8505581 - 财政年份:2013
- 资助金额:
$ 70.26万 - 项目类别:
Fibromyalgia Activity Study with TENS "FAST"
使用 TENS“FAST”进行纤维肌痛活动研究
- 批准号:
9127091 - 财政年份:2013
- 资助金额:
$ 70.26万 - 项目类别:
Skeletal muscle biology in rheumatoid arthritis
类风湿性关节炎的骨骼肌生物学
- 批准号:
8775450 - 财政年份:2012
- 资助金额:
$ 70.26万 - 项目类别:
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