2013 Aging, Biology of Gordon Research Conference and Gordon Research Seminar

描述（由申请人提供）：2013年戈登老龄生物学研究会议（GRC）将是自1962年该系列成立以来的第二十九届。这一系列是重要的，因为研究在基础生物学的老化一直很少代表在大型社会会议，传统上一直保持一个主要强调老年学问题及其医学，社会和心理后果。因此，基础科学研究人员一直在寻求GRC对衰老生物学的理想论坛，讨论该领域的最新进展，介绍新的实验模型，挑战范式，建立网络和启动合作项目。随着衰老领域的成熟，它已经准备好开始将生物学的各个领域整合到模型生物体的衰老基础生物学中。同样变得明显的是，各种细胞过程和组织的稳态随着年龄的增长而下降，这是衰老过程的原因。因此，2013年关于衰老生物学的GRC将专注于“稳态和衰老”。“该计划的重点是如何稳态的细胞过程，包括生物钟，干性，线粒体功能，脂肪代谢和蛋白质周转随着年龄的增长而下降，是衰老过程的原因。此外，该会议旨在研究包括肌肉，脂肪，神经元和肠道在内的各种组织如何随着年龄的增长而衰退，并导致系统范围的扰动，从而导致生物体的整体衰退。所有这些都大大扩展了老龄化研究的视野，并建议寻求有可能提高健康寿命的干预措施。虽然我们对衰老生物学的大部分知识都来自于使用模型生物的研究，但最近，人类已成为实验的对象，这些实验测试了这些机制的保守程度以及它们如何影响人类的衰老和与年龄相关的疾病。因此，这些不同领域的研究人员之间的相互反馈是2013年衰老生物学GRC的主要目标之一。为了实现这一目标，2013年关于衰老生物学的GRC将：1）促进对关键问题的公开讨论，特别强调可能对人类衰老具有重要转化潜力的新机制; 2）提供一个论坛，讨论衰老生物学研究的最新进展， 老化; 3）促进思想交流和研究结果的交流，这可能会影响该领域的未来目标; 4）促进网络建设，发起国际合作努力和联盟;以及，5）促进初级研究人员融入老龄化研究人员的既定社区。最后一个目标将通过包括戈登-凯南研究研讨会来实现，该研讨会致力于为学员充分参与GRC做好智力和心理准备。

DESCRIPTION (provided by applicant): The 2013 Gordon Research Conference (GRC) on Biology of Aging will be the twenty-ninth of its kind since inception of the series in 1962. This series is important because research in basic biology of aging has been poorly represented in the large society meetings that have traditionally maintained a major emphasis on gerontological issues and their medical, social, and psychological ramifications. Consequently, basic science investigators have sought the GRC on Biology of Aging as the ideal forum for discussion of recent advances in the field, presentation of new experimental models, challenge of paradigms, networking, and initiation of collaborative projects. As the aging field matures, it s ready to begin to integrate various areas of biology into the basic biology of aging in model organisms. It is also becoming apparent that homeostasis of various cellular processes and tissues declines with age which is causal to the aging process. Hence, the 2013 GRC on the Biology of Aging will focus on "homeostasis and aging." The program focuses on how homeostasis of cellular processes including circadian clocks, stemness, mitochondrial function, fat metabolism and protein turnover declines with age and is causal to the aging process. Furthermore, the conference aims to examine how various tissues including muscle, fat, neurons and gut decline with age and cause system wide perturbations that cause global decline of the organism. All of these greatly expand the horizons of aging research and suggest the pursuit of interventions that have the potential to enhance health span. While much of our knowledge about the biology of aging has derived from studies using model organisms, recently, humans have become the subjects of experiments that test how well these mechanisms are conserved and how they impact aging and age-related diseases in humans. Therefore, reciprocal feedback between investigators in these diverse fields is one of the main objectives of the 2013 Biology of Aging GRC. To accomplish this objective, the 2013 GRC on the Biology of Aging will: 1) promote open discussion of critical questions with particular emphasis on novel mechanisms that could have important translational potential for human aging; 2) provide a forum for the discussion of state-of-the art advances in research in biology of aging; 3) facilitate exchange of ideas and communication of findings that could shape the future goals of the field; 4) promote networking, initiation of international cooperative efforts, and consortiums; and, 5) promote the integration of junior investigators into the established community of aging researchers. This last objective will be met by inclusion of a Gordon-Kenan Research Seminar dedicated to the intellectual and psychological preparation of trainees for full participation in the GRC to follow.