Changes in Physical and Cognitive Functioning among Cancer Survivors

癌症幸存者身体和认知功能的变化

• 批准号: 8512508
• 负责人: Krista Garcia
• 金额: $ 6.79万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512508
• 关键词: Acute; Address; Adult; Age; Cancer Burden; Cancer Survivor; Caring; Cause of Death; Centers for Disease Control and Prevention (U.S.); Cessation of life; Characteristics; Chronic; Clinical Trials; Cognitive; Comorbidity; Data; Data Set; Diagnosis; Diagnostic; Disease; Elderly; Exhibits; Funding; Health; Health behavior; Individual; Information Systems; Intervention; Length; Link; Logistic Regressions; Long-Term Effects; Long-Term Survivors; Malignant Neoplasms; Medical; Medicare claim; Minority; Minority Groups; Modality; Modeling; Newly Diagnosed; Outcome; Pattern; Persons; Phase; Physical Function; Population; Quality of life; Race; Recording of previous events; Reporting; Research; Respondent; Retirement; Risk; Sampling; Social Conditions; Survivors; Testing; Time; Treatment Protocols; age effect; age related; base; cancer diagnosis; cancer type; cognitive function; cohort; data registry; disability; experience; follow-up; health economics; improved; indexing; insight; meetings; mortality; multilevel analysis; public health relevance; social; socioeconomics; survivorship; treatment site; tumor

DESCRIPTION (provided by applicant): The objective of the proposed research is to examine the impact of a cancer diagnosis on physical and cognitive functioning among older cancer survivors based on longitudinal data from the NIA-funded Health and Retirement Study. Public use HRS data from ten waves (1992-2010) will be linked to restricted HRS cancer data to identify respondents newly diagnosed with cancer and to form cohorts by major types of cancer. Data on sociodemographics, co-morbidities, and health behaviors, will be used to assess differences in physical and cognitive functioning exhibited at subsequent time points among cancer survivors and compared to persons with no history of cancer, to help separate the effects of cancer from the normal effects of aging. These data will be linked to the HRS Medicare Claims and Summary Data (2007) to identify extent of disease and treatment modality(s). Multilevel modeling and logistic regression models will be used to examine change over time and the association between predictors and patterns of change. This research will test the hypothesis that the diagnosis of cancer has a significant negative effect on physical and cognitive functioning separate from the normal effects of aging. We hypothesize that the risk of adverse changes in physical and cognitive functioning after a cancer diagnosis is influenced by various treatment-related factors as well as by socioeconomic and health factors present before and/or after diagnosis. Insight gained from the proposed project will improve our understanding of the adverse physical and cognitive health outcomes following a cancer diagnosis in older adults and will inform interventions targeted at addressing both age-related and cancer-related consequences to improve the quality of life for long-term cancer survivors.

描述（由申请人提供）：拟议研究的目的是根据NIA资助的健康和退休研究的纵向数据，检查癌症诊断对老年癌症幸存者身体和认知功能的影响。公众使用的HRS数据从十波（1992-2010年）将被链接到限制HRS癌症数据，以确定新诊断为癌症的受访者，并形成队列的主要类型的癌症。关于社会人口统计学、共病和健康行为的数据将用于评估癌症幸存者在随后的时间点表现出的身体和认知功能差异，并与无癌症史的人进行比较，以帮助将癌症的影响与衰老的正常影响分开。这些数据将与HRS医疗保险索赔和汇总数据（2007年）相关联，以确定疾病程度和治疗方式。将使用多层次建模和逻辑回归模型来检查随时间的变化以及预测因素与变化模式之间的关联。这项研究将检验一个假设，即癌症的诊断对身体和认知功能有显着的负面影响，与衰老的正常影响分开。我们假设癌症诊断后身体和认知功能不良变化的风险受到各种治疗相关因素以及诊断前和/或诊断后存在的社会经济和健康因素的影响。从拟议项目中获得的见解将提高我们对老年人癌症诊断后不良身体和认知健康结果的了解，并将为针对解决年龄相关和癌症相关后果的干预措施提供信息，以提高长期癌症患者的生活质量。幸存者。