Inflammatory Biology Core

项目概述（见说明）：OAIC炎症生物学核心（IBC）提供了一种机制，通过该机制，加州大学洛杉矶分校和其他机构的OAIC研究项目可以将炎症生物学的全面蛋白质和分子分析纳入研究，a)确定导致脆弱成人疾病和残疾的生物和/或行为因素，b)针对炎症或与炎症相关的生物行为风险特征开发有效的预防或治疗干预措施。c)将炎症生物学、生物标志物和成功临床干预机制的新知识引入临床实践和决策。IBC的重点是促进基础研究和临床研究之间的联系，并为OAIC研究项目提供机会，研究炎症的潜在分子遗传学和炎症对其他细胞过程的影响，战略重点是将这些知识转化为识别和减少老年人慢性疾病和残疾的风险。IBC旨在扩大和支持（智力支持和分析服务）现有的加州大学洛杉矶分校OAIC研究项目、新的OAIC试点项目和开发研究项目中的炎症生物学分析。IBC还将开发新的分析方法，以促进体内炎症动力学分析及其对老年人的功能基因组影响。最后，IBC将提供炎症生物学的行为、免疫学和分子方面的培训，因为它们与衰老的独特问题有关。该培训将强调有关炎症信号来源和目标的生物学知识（包括遗传和表观遗传影响以及基因表达后果），特别侧重于行为和功能影响。总之，炎症生物学核心是加州大学洛杉矶分校OAIC的一个组成部分，为炎症生物学评估提供专家咨询，监督炎症生物标志物的收集和分析，为OAIC试点项目和CDA获奖项目提供数据解释，并为众多外部资助项目提供支持。鉴于炎症在影响老年人的疾病中的突出作用，以及随着年龄增长而改变的炎症动力学，全面评估炎症生物学对于OAlC的中心目标至关重要，即开发预防美国老年人疾病和残疾的干预措施，并将这些知识转化为更有效的临床实践。

PROJECT SUMMARY (See instructions): The OAIC Inflammatory Biology Core (IBC) provides a mechanism by which OAIC research programs at UCLA and other institutions can incorporate comprehensive protein and molecular analyses of inflammatory biology into studies that a) identify biologic and/or behavioral factors that contribute to disease and disability in vulnerable adults, b) develop effective preventive or therapeutic interventions that target inflammation or biobehavioral risk profiles associated with inflammation, and c) bring new knowledge about inflammatory biology biomarkers and mechanisms underlying successful clinical intervention into clinical practice and decision-making. The IBC focuses on stimulating links between basic and clinical research, and provides opportunities for OAIC research projects to examine the underlying molecular genetics of inflammation and the effects of inflammation on other cellular processes, with a strategic focus on the translation of such knowledge into the identification and reduction of risk for chronic disease and disability in older adults. The IBC aims to expand and support (both intellectual support and assay services) the analysis of inflammatory biology in existing UCLA OAIC research programs and in new OAIC pilot projects and developing research programs. The IBC will also develop new analytic approaches to facilitate in vivo analysis of inflammatory dynamics and their functional genomic impact on elderly individuals. Finally, the IBC will provide training in behavioral, immunologic, and molecular aspects of inflammatory biology in general, and as they pertain to the unique issues in aging. This training will emphasize biological knowledge about the sources and targets of inflammatory signals (including genetic and epigenetic influences and gene expression consequences), with a particular focus on behavioral and functional impacts. In summary, the Inflammatory Biology Core forms an integral part of the UCLA OAIC, providing expert consultation on the assessment of inflammatory biology, oversight of inflammatory biomarker collection and assay, and interpretation of data for OAIC pilot projects and CDA awardees as well as support for numerous externally-funded projects. Given the prominent role of inflammation in the diseases that impact older adults, and the altered inflammatory dynamics that accompany aging, comprehensive assessment of inflammatory biology is critical to OAlC's central goal to develop interventions that prevent disease and disability in older Americans, and to translate such knowledge into more effective clinical practice.