UCLA Older Americans Independence Center

UCLA Claude Pepper老年美国人独立中心（OAIC）旨在促进旨在维持和恢复老年人独立性的研究。通过其主题“预防弱势群体的疾病和残疾：一种转化方法”，UCLA OAlC的研究范围从T1到T2转化研究。在这个主题中，UCLA OAIC的一个重要重点是了解炎症在疾病和残疾中的作用。 为了实现其目标，UCLA OAIC已经建立了4个研究核心（招募和保留，研究运营，分析和成本效益，以及炎症生物学）和一个新的信息传播核心，这将促进OAIC相关研究的每一步（招募，测量，数据管理，分析，解释和采用结果）。研究核心在4个层面提供支持： 咨询（例如，提供长达数小时的建议，阅读论文或提案） 关于新提案的伙伴关系 短期（例如，长达2-3天的咨询，进行分析） 持续或长期支持（例如，正在进行，项目小组的一部分） 此外，加州大学洛杉矶分校的OAIC试点和探索性研究核心和研究职业发展核心通过初级研究人员和试点奖励的管道刺激新的研究，并招募成功的研究人员进入OAIC相关的研究。领导/行政核心确保完成这些具体活动，并以最佳方式实现UCLA OAIC的目标。 加州大学洛杉矶分校OAIC将解决弱势老年人面临的健康差距，因为1）对贡献者的了解不足（例如，社会经济地位，炎症）与健康和特定疾病（例如，艾滋病毒、睡眠、抑郁症），2）缺乏有效的预防或治疗方法（生物医学和行为），或3）弱势老年人群获得所需治疗的能力不足（例如，文化障碍，无效的医疗保健系统）。通过OAIC集中精力和资源，可以加快研究开发、测试和传播有前途的创新以保持独立性的时间轴。

DESCRIPTION (provided by applicant): The UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to promote research aimed at maintaining and restoring the independence of older persons. Through its theme of Preventing Disease and Disability in Vulnerable Populations: a Translational Approach, the UCLA OAlC's research extends across the full spectrum from Tl to T2 translational research. Within this theme, an important focus of the UCLA OAIC is on understanding the role of inflammation in disease and disability. To accomplish its goals, the UCLA OAIC has established 4 Research Cores (Recruitment and Retention, Research Operations, Analysis and Cost Effectiveness, and Inflammatory Biology) and a new Information Dissemination Core that will facilitate OAlC-related research at every step (recruitment, measurement, data management, analysis, interpretation, and adoption of findings). Research cores provide support at 4 levels: Consultation (e.g., providing up to several hours of advice, reading a paper or a proposal) Partnership on new proposals Short-term (e.g., up to 2-3 days of consultation, performing assays) Ongoing or long-term support (e.g., ongoing, part of the project team) In addition, the UCLA OAIC Pilot and Exploratory Studies Core and Research Career Development Core stimulate new research via a pipeline of junior investigators and pilot awards and recruit successful investigators into OAlC-related research. The Leadership/Administrative Core ensures that these specific activities are accomplished and the goals of the UCLA OAIC are optimally achieved. The UCLA OAIC will address health disparities that vulnerable older persons face because of 1) inadequate understanding of contributors (e.g., socioeconomic status, inflammation) to health and specific illnesses (e.g., HIV, sleep, depression), 2) lack of effective preventive or therapeutc approaches (biomedical and behavioral), or 3) inadequate ability to get needed treatment to vulnerable older populations (e.g., cultural barriers, ineffective health care systems). By focusin efforts and resources through the OAIC, the timeline for research to develop, test, and disseminate promising innovations to maintain independence can be accelerated.