2013 Nucleosides, Nucleotides, and Oligonucleotides Gordon Research Conference

描述（由申请人提供）：本提案要求对核苷、核苷酸和寡核苷酸会议提供部分支持，作为戈登研究会议系列的一部分，该会议将于2013年6月30日至7月5日在Salve Regina大学（纽波特，RI）举行。会议的广泛和长期目标是增加我们对核苷，核苷酸和寡核苷酸的化学和生物学的理解。这次会议的具体目标是召集9名讨论领导人主持9场会议。主席和副主席将监督整个会议。共有29位受邀演讲者，他们将代表核苷，核苷酸和寡核苷酸的化学和生物学的关键领域，以及8位口头学生/博士后演讲。该计划将有一个主题演讲和九个会议，广泛讨论核酸化学，DNA修复，抗癌和抗病毒剂的发现，合成生物学，细菌中的核苷酸代谢，嘌呤和嘧啶代谢的酶学和RNA代谢的当前问题。主题演讲将由托马斯施泰茨博士主讲，他因在核糖体结构和功能方面的工作而获得2009年诺贝尔化学奖。此外，两次晚间海报展示会将使所有与会者都能为会议作出贡献。与所有戈登会议一样，年轻的调查人员、妇女和少数民族将有许多机会与该领域的高级领导人互动。这一应用的意义在于，戈登研究会议是唯一一个专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的平台。核苷类似物通过不同的机制起作用，对于治疗癌症和包括艾滋病在内的几种病毒性疾病非常有效。此外，siRNA、miRNA、反义RNA、催化RNA等核酸类似物也是药物开发中最令人兴奋的新领域之一。除了成为各种疾病的预后和诊断的主要工具外，寡核苷酸还被用作表观遗传学、合成生物学和系统化学的新工具，这将成为未来产生新药的重要技术。会议将集中在所有这些新领域，并将成为一个讨论论坛和交流平台，以产生新的知识和合作。因此，本次会议在其健康相关性方面具有重要意义，因为化学家和生物学家之间的讨论将产生新的知识和开发新疗法的途径。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from June 30, to July 5, 2013. The broad and long term goal of the conference is to increase our understanding of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. A chair and vice-chair will supervise the whole conference. There will be a total of 29 invited speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides and 8 oral student/postdoctoral presentations. The program will have a keynote lecture and nine sessions that broadly address current issues in nucleic acid chemistry, DNA repair, discovery of anticancer and antiviral agents, synthetic biology, nucleotide metabolism in bacteria, enzymology of purine and pyrimidine metabolism, and RNA metabolism. The keynote lecture will be given by Dr. Thomas Steitz, who won the Nobel Prize in Chemistry in 2009 for his work on the structure and function of the ribosome. In addition, two evening poster sessions will permit all participants to contribute to the meeting. As with all Gordon Conferences there will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Nucleoside analogs, acting by diverse mechanisms, are highly effective for the treatment of cancer and several viral diseases including AIDS. In addition, nucleic acids analogs as siRNA, miRNA, antisense, catalytic RNA belong to one of the most exciting new areas in drug development. Besides becoming major tools for prognosis and diagnosis of various diseases, oligonucleotides are also used as new tools in epigenetics, synthetic biology and systems chemistry, which will become important technologies for generating new drugs for the future. The conference will focus on all these new areas and will be a discussion forum and an exchange platform for generating new knowledge and collaborations. This conference is therefore highly significant regarding its health relatedness, as the discussions among chemists and biologists will generate new knowledge and avenues for development of novel therapeutics.