2013 Nucleosides, Nucleotides, and Oligonucleotides Gordon Research Conference

描述(由申请人提供)：本提案请求部分支持将于2013年6月30日至7月5日在RI纽波特的Salve Regina大学举行的关于核苷、核苷酸和寡核苷酸的会议，作为戈登研究会议系列的一部分。会议的广泛和长期目标是增加我们对核苷、核苷酸和寡核苷酸的化学和生物学的了解。本次会议的具体目标是召集9位讨论领袖主持9场会议。一名主席和一名副主席将监督整个会议。共有29名受邀演讲者将代表核苷、核苷酸和寡核苷酸化学和生物学的关键领域，并将有8名学生/博士后口头报告。该计划将有一次主旨演讲和九次会议，广泛讨论当前的问题，包括核酸化学、DNA修复、抗癌和抗病毒药物的发现、合成生物学、细菌中的核苷酸代谢、嘌呤和嘧啶代谢的酶学以及RNA代谢。主旨演讲将由托马斯·斯泰茨博士主持，他因在核糖体结构和功能方面的工作而获得2009年诺贝尔化学奖。此外，两次晚间海报会议将允许所有与会者为会议做出贡献。与所有戈登会议一样，年轻的研究人员、女性和少数族裔将有许多机会与该领域的高级领导人互动。这一应用的意义在于，戈登研究会议是专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的唯一平台。核苷类似物通过不同的作用机制，对癌症和包括艾滋病在内的几种病毒疾病的治疗非常有效。此外，siRNA、miRNA、反义、催化RNA等核酸类似物属于药物开发中最令人兴奋的新领域之一。寡核苷酸除了成为预测和诊断各种疾病的主要工具外，还被用作表观遗传学、合成生物学和系统化学的新工具，将成为未来产生新药的重要技术。会议将聚焦于所有这些新领域，并将成为一个讨论论坛和交流平台，以产生新的知识和合作。因此，这次会议具有非常重要的意义，因为化学家和生物学家之间的讨论将产生新的知识和新的治疗方法的发展途径。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from June 30, to July 5, 2013. The broad and long term goal of the conference is to increase our understanding of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. A chair and vice-chair will supervise the whole conference. There will be a total of 29 invited speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides and 8 oral student/postdoctoral presentations. The program will have a keynote lecture and nine sessions that broadly address current issues in nucleic acid chemistry, DNA repair, discovery of anticancer and antiviral agents, synthetic biology, nucleotide metabolism in bacteria, enzymology of purine and pyrimidine metabolism, and RNA metabolism. The keynote lecture will be given by Dr. Thomas Steitz, who won the Nobel Prize in Chemistry in 2009 for his work on the structure and function of the ribosome. In addition, two evening poster sessions will permit all participants to contribute to the meeting. As with all Gordon Conferences there will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Nucleoside analogs, acting by diverse mechanisms, are highly effective for the treatment of cancer and several viral diseases including AIDS. In addition, nucleic acids analogs as siRNA, miRNA, antisense, catalytic RNA belong to one of the most exciting new areas in drug development. Besides becoming major tools for prognosis and diagnosis of various diseases, oligonucleotides are also used as new tools in epigenetics, synthetic biology and systems chemistry, which will become important technologies for generating new drugs for the future. The conference will focus on all these new areas and will be a discussion forum and an exchange platform for generating new knowledge and collaborations. This conference is therefore highly significant regarding its health relatedness, as the discussions among chemists and biologists will generate new knowledge and avenues for development of novel therapeutics.