2011 Nucleosides, Nucleotides, and Oligonucleotides GRC

描述（由申请人提供）：本提案要求部分支持核苷、核苷酸和寡核苷酸会议，作为戈登研究会议系列的一部分，该会议将于2011年7月3日至8日在RI新港的Salve Regina大学举行。会议的广泛和长期目标是增加我们对核苷、核苷酸和寡核苷酸化学的理解。这些制剂作为诊断工具和治疗危及生命的疾病的药物的生物学意义将补充化学以及它们在理解生物过程中的用途。这次会议的具体目标是召集9位讨论领导人主持9次会议。会议主席和副主席将监督整个会议。将有21位演讲者，他们将代表核苷，核苷酸和寡核苷酸的化学和生物学的关键领域，以及10个口头学生报告。该计划将有一个主题演讲和八个会议，广泛讨论合成生物学，系统化学，DNA和RNA结构，基因表达的转录控制，核苷类似物作为治疗剂，核苷酸受体，催化RNA和表观遗传学方面的当前问题。主讲将由J·绍斯塔克（2009年诺贝尔奖得主）主讲。此外，两个晚上的海报会议将允许所有参与者对这些主题作出贡献。会议将为年轻的研究人员、妇女和少数民族提供许多与该领域高级领导人互动的机会。这一应用的意义在于，戈登研究会议是化学家和生物学家聚集在一起研究核苷、核苷酸和寡核苷酸的唯一平台。核苷类似物通过多种机制发挥作用，对治疗实体瘤和血液系统恶性肿瘤以及包括艾滋病在内的几种病毒性疾病非常有效。核酸类似物如siRNA、miRNA、反义RNA、催化RNA属于药物开发中最令人兴奋的新领域。因此，这次会议就其与健康的关系而言具有重要意义。化学家和科学家之间的讨论将为开发新的治疗方法产生新的知识和途径。寡核苷酸除了成为疾病预后和诊断的重要工具外，还在表观遗传学、合成生物学和系统化学等领域得到了广泛的应用，将成为未来产生新药的重要技术。会议将重点关注所有这些新领域，并将成为产生新知识和合作的讨论论坛和交流平台。

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as a part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from July 3 - 8, 2011. The broad and long term goal of the conference is to increase our understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides. The biological significance of these agents as tools for diagnosis and as drugs for treatment of life-threatening diseases will complement the chemistry as well as their use in understanding biological processes. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. Chair and vice-chair of the conference will supervise the whole conference. There will be 21 speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides and 10 oral student presentations. The program will have a keynote address and eight sessions that broadly address current issues in synthetic biology, systems chemistry, DNA and RNA structures, transcription control of gene expression, nucleoside analogues as therapeutic agents, nucleotide receptors, catalytic RNA and epigenetics. The key note lecture will be given by J Szostack (Nobel Prize, 2009). In addition, two evening poster sessions will permit all participants to contribute to these topics. The meeting will provide numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Nucleoside analogs, acting by diverse mechanisms, are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS. Nucleic acids analogs as siRNA, miRNA, antisense, catalytic RNA belong to the most exciting new areas in drug development. This conference is therefore highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Besides becoming major tools for prognosis and diagnosis of diseases, oligonucleotides are widely used as new tools in epigenetics, synthetic biology and systems chemistry, which will become important technologies for generating new drugs for the future. The conference will focus on all these new areas and will be a discussion forum and an exchange platform for generating new knowledge and collaborations. PUBLIC HEALTH RELEVANCE: There are numerous anticancer and antiviral drugs that work by inhibition of enzymes involved in nucleic acid metabolism. The goal of the Nucleoside, Nucleotide & Oligonucleotide Gordon Research conference is to aid investigators learn about the newest developments in this field. There will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. This conference will promote an enhanced understanding of an important cellular metabolic process and lead to collaborations amongst scientists of various disciplines that could lead to future drug development.