2011 Nucleosides, Nucleotides, and Oligonucleotides GRC

2011 核苷、核苷酸和寡核苷酸 GRC

• 批准号: 8116777
• 负责人: WILLIAM B PARKER
• 金额: $ 0.35万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-14 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8116777
• 关键词: Acquired Immunodeficiency Syndrome; Address; Antineoplastic Agents; Antiviral Agents; Area; Biochemistry; Biological; Biological Process; Biology; Catalytic RNA; Cellular Metabolic Process; Chemistry; Collaborations; Complement; DNA; Development; Diagnosis; Discipline; Disease; Enzyme Inhibition; Epigenetic Process; Future; Gene Expression; Genetic Transcription; Goals; Health; Hematologic Neoplasms; Knowledge; Lead; Learning; Life; MicroRNAs; Minority; New Agents; Nobel Prize; Nucleosides; Nucleotides; Ointments; Oligonucleotides; Oral; Participant; Pharmaceutical Preparations; Process; RNA; Request for Proposals; Research; Research Personnel; Scientist; Series; Small Interfering RNA; Solid Neoplasm; Structure; Students; System; Technology; Therapeutic Agents; Universities; Virus Diseases; Woman; Work; cancer therapy; disease diagnosis; drug development; effective therapy; lecture notes; meetings; novel therapeutics; nucleic acid analog; nucleic acid metabolism; nucleoside analog; nucleotide receptor; outcome forecast; posters; programs; symposium; synthetic biology; tool

DESCRIPTION (provided by applicant): This proposal requests partial support for a meeting on Nucleosides, Nucleotides, and Oligonucleotides as a part of the Gordon Research Conference series to be held in Salve Regina University, Newport, RI from July 3 - 8, 2011. The broad and long term goal of the conference is to increase our understanding of the chemistry of nucleosides, nucleotides, and oligonucleotides. The biological significance of these agents as tools for diagnosis and as drugs for treatment of life-threatening diseases will complement the chemistry as well as their use in understanding biological processes. The specific aims of this meeting will be to convene nine discussion leaders to moderate nine sessions. Chair and vice-chair of the conference will supervise the whole conference. There will be 21 speakers who will represent critical areas of the chemistry and biology of nucleosides, nucleotides, and oligonucleotides and 10 oral student presentations. The program will have a keynote address and eight sessions that broadly address current issues in synthetic biology, systems chemistry, DNA and RNA structures, transcription control of gene expression, nucleoside analogues as therapeutic agents, nucleotide receptors, catalytic RNA and epigenetics. The key note lecture will be given by J Szostack (Nobel Prize, 2009). In addition, two evening poster sessions will permit all participants to contribute to these topics. The meeting will provide numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. The significance of this application is that the Gordon Research Conference is the only platform where chemists and biologists who focus on nucleosides, nucleotides, and oligonucleotides come together. Nucleoside analogs, acting by diverse mechanisms, are highly effective for treatment of solid tumor and hematological malignancies and several viral diseases including AIDS. Nucleic acids analogs as siRNA, miRNA, antisense, catalytic RNA belong to the most exciting new areas in drug development. This conference is therefore highly significant regarding its health relatedness. The discussions among chemists and scientists will generate new knowledge and avenues for development of novel therapeutics. Besides becoming major tools for prognosis and diagnosis of diseases, oligonucleotides are widely used as new tools in epigenetics, synthetic biology and systems chemistry, which will become important technologies for generating new drugs for the future. The conference will focus on all these new areas and will be a discussion forum and an exchange platform for generating new knowledge and collaborations. PUBLIC HEALTH RELEVANCE: There are numerous anticancer and antiviral drugs that work by inhibition of enzymes involved in nucleic acid metabolism. The goal of the Nucleoside, Nucleotide & Oligonucleotide Gordon Research conference is to aid investigators learn about the newest developments in this field. There will be numerous opportunities for young investigators, women, and minorities to interact with senior leaders in the field. This conference will promote an enhanced understanding of an important cellular metabolic process and lead to collaborations amongst scientists of various disciplines that could lead to future drug development.

描述（由申请人提供）：本提案要求对核苷、核苷酸和寡核苷酸会议提供部分支持，作为戈登研究会议系列的一部分，该会议将于2011年7月3日至8日在Salve Regina大学（纽波特，RI）举行。会议的广泛和长期目标是增加我们对核苷，核苷酸和寡核苷酸化学的理解。这些试剂作为诊断工具和治疗危及生命的疾病的药物的生物学意义将补充化学以及它们在理解生物过程中的用途。这次会议的具体目标是召集9名讨论领导人主持9场会议。大会主席和副主席将监督整个会议。将有21位演讲者将代表核苷，核苷酸和寡核苷酸的化学和生物学的关键领域和10个口头学生报告。该计划将有一个主题演讲和八个会议，广泛讨论合成生物学，系统化学，DNA和RNA结构，基因表达的转录控制，核苷类似物作为治疗剂，核苷酸受体，催化RNA和表观遗传学的当前问题。主题演讲将由J Szostack（诺贝尔奖，2009年）。此外，两次晚间海报会议将使所有与会者都能对这些主题作出贡献。会议将为年轻的调查人员、妇女和少数民族提供许多机会，与该领域的高级领导人进行互动。这一应用的意义在于，戈登研究会议是唯一一个专注于核苷、核苷酸和寡核苷酸的化学家和生物学家聚集在一起的平台。核苷类似物通过不同的机制起作用，对实体瘤和血液恶性肿瘤以及包括AIDS在内的几种病毒性疾病的治疗非常有效。siRNA、miRNA、反义RNA、催化RNA等核酸类似物是药物开发中最令人兴奋的新领域。因此，这次会议就其与健康的关系而言具有非常重要的意义。化学家和科学家之间的讨论将产生新的知识和新疗法的发展途径。除了成为疾病预后和诊断的主要工具外，寡核苷酸还被广泛用作表观遗传学，合成生物学和系统化学的新工具，这将成为未来产生新药的重要技术。会议将集中在所有这些新领域，并将成为一个讨论论坛和交流平台，以产生新的知识和合作。 公共卫生相关性：有许多抗癌和抗病毒药物通过抑制参与核酸代谢的酶来发挥作用。核苷，核苷酸和寡核苷酸戈登研究会议的目标是帮助研究人员了解该领域的最新发展。年轻的调查人员、妇女和少数民族将有许多机会与该领域的高级领导人互动。本次会议将促进对重要细胞代谢过程的深入理解，并导致不同学科科学家之间的合作，从而可能导致未来的药物开发。