FASEB SRC on Signal Transduction in the Immune System

描述（由申请人提供）：本申请旨在为FASEB夏季会议“免疫系统中的信号转导”提供部分资金，该会议将于2013年6月19日至24日在巴哈马拿骚举行，未来的会议将于2015年和2017年举行。本次会议的主要目标是全面关注有关健康和疾病中免疫细胞反应的信号机制的最新进展。2013年的会议将是FASEB会议的第七次会议。这次会议已经在研究机构，学术界和工业界引起了广泛的兴趣，因为杰出的发言者名单，所提出的工作的前沿性和许多演讲与免疫疾病的相关性。此外，由于大多数主流免疫学会议不提供对信号转导机制的深入关注，这个专门的FASEB会议吸引了全球免疫信号转导领域的领导者，以及新的研究人员和学生。因此，本次FASEB会议是FASEB夏季会议中参加人数最多的会议之一。计划于2013年举行的会议包括联合强调适应性和先天免疫信号机制。2013年的会议包括一个强烈的关注细胞骨架的变化，调节白细胞活化和迁移，在淋巴细胞分化过程中代谢途径的重要性，并使用显微镜和数学建模，以揭示白细胞受体信号的详细生化机制，以及最近的突破应用于人类疾病的治疗。这些主题代表了免疫信号传导，生物学和转化为人类疾病的交叉研究的前沿。会议有一个骨干的定期与会者和发言者，但我们将确保新的想法和领域是在2013年由25个新的发言者。此外，每个会议都有空间从摘要中选择几个简短的演讲，优先考虑新的研究者或来自PI不在场的小组的博士后。这将确保会议议题的多样性。会议的总体目标是：1.提供一个关键的和密集的概述免疫信号的最新进展; 2.将资深科学家和年轻研究人员聚集在一起，在欢乐的气氛中进行非正式讨论，以提高学生和年轻研究人员的技能;通过广泛传播信息和最新突破，推进免疫系统分子机制的研究。我们预计，这次会议将建立在过去的会议在影响免疫信号研究的方向的成功。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System", to be held June 19-24, 2013 Nassau, Bahamas, with future meetings to be held in 2015 and 2017. The major goal of this conference is to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the response of immune cells in both health and disease. The meeting in 2013 will be the 7th occurrence of this FASEB conference. This conference has garnered widespread interest in research institutes, academia, and industry because of the outstanding speaker rosters, the cutting edge nature of the work presented and the relevance of many presentations to immunologic diseases. Additionally, since most mainstream immunology meetings do not provide an in-depth focus on signal transduction mechanisms, this dedicated FASEB conference has attracted leaders in immune signal transduction world-wide, as well as new investigators and students. As a result, this FASEB conference has been one of the most highly attended FASEB Summer conferences. The meeting planned for 2013 includes a joint emphasis on adaptive and innate immune signaling mechanisms. The 2013 conference includes a strong focus on cytoskeletal changes that regulate leukocyte activation and migration, the importance of metabolic pathways during lymphocyte differentiation, and the use of microscopy and mathematical modeling to uncover detailed biochemical mechanisms of leukocyte receptor signaling as well as the application of recent breakthroughs to the treatment of human disease. These topics represent the cutting edge of research at the intersection of immune signaling, biology and translational to human disease. The conference has a backbone of regular attendees and speakers, but we will ensure that new ideas and areas are addressed in 2013 by featuring 25 new speakers. In addition, each session has space for several short talks to be selected from abstracts, with priority given to new investigators or post-docs from groups in which PIs are not presenting. This will ensure a diversity of topics at the meeting. The overall objectives of the meeting are: 1. To provide a critical and intensive overview of the recent advances in immune signaling; 2. To bring together senior scientists and young investigators in a convivial atmosphere with informal discussions to promote the skills of students and young investigators; 3. To advance research on the molecular mechanisms in the immune system by broadly disseminating information and recent breakthroughs. We anticipate that this conference will build upon the success of past conferences in influencing the direction of immune signaling research.