2013 Antimicrobial Peptides GRC/GRS

描述(由申请人提供)：第9届戈登抗菌肽研究会议(GRC)将于2月24日至3月1日在加利福尼亚州文图拉举行。AMP是所有后生动物(包括细菌、真菌、植物、无脊椎动物、脊椎动物和包括人类在内的哺乳动物)使用的天然免疫的内源性成分。它们充当天然抗生素，阻止入侵和杀死病原体，并限制非致病微生物的生长。抗生素耐药微生物的出现突显了研究AMPs的必要性。此外，更多的证据表明，AMP在各种生物环境中调节宿主防御，并可以以不同于其抗菌功能的方式发挥作用， 通过受体介导的炎症相关活动，如趋化或诱导细胞因子的产生，支持AMP是多功能宿主防御效应分子的假说。最近的证据表明，微生物和宿主来源的AMP在维持调节共生微生物群的组成和保护宿主免受感染方面发挥了作用。了解AMPs在免疫反应中的作用将有助于更好地理解和治疗人类疾病的病理生理学，包括炎症性肠病、性传播和机会性感染、特应性皮炎等。节目将分为9个环节的口头陈述和4个海报环节。会议由Nita Salzman博士和Gill Diamond博士以及联席副主席Julia Dorin博士和Pieter Hiemstra博士共同主持，并将由Jules Hoffmann教授发表主题演讲。将特别注意初级教职员工和学生参与者。演讲者将包括根据最近的重要发现预先选择的人，以及从提交的摘要中选择的人。会议主题包括：抗菌宿主防御的保护；作为抗病毒药物的AMPS；对抗真菌和寄生虫的宿主防御；环状AMPS；界面上的AMPS；抗菌和超越；AMPS与免疫；以及AMPS的新技术和应用。与会者之间有充分的时间进行有组织的讨论和非正式互动。此外，包括《热点新闻》在内的日常会议将致力于讨论当前调查的前沿话题。组织理念是鼓励不同的参与，并关注性别问题、初级科学家、少数群体和身体有缺陷的个人。

DESCRIPTION (provided by applicant): The 9th Gordon Research Conference (GRC) on Antimicrobial Peptides (AMPs) will meet in Ventura, CA, from February 24-March 1. AMPs are endogenous components of innate immunity used by all metazoans including bacteria, fungi, plants, invertebrates, vertebrates, and mammals including humans. They act as natural antibiotics by prohibiting invasion and killing pathogens, and by restricting growth of non-pathogenic microbes. The emergence of antibiotic-resistant microorganisms underscores the need to study AMPs. Furthermore, additional evidence shows that AMPs mediate host defense in a variety of biological settings and can act in ways distinct from their antimicrobial function, via receptor-mediated inflammation- associated activities such as chemotaxis or induction of cytokine production, supporting the hypothesis that AMPs are multifunctional host defense effector molecules. Recent evidence indicates a role of microbe- and host-derived AMPs in maintaining regulating the composition of the commensal microbiota and protection of the host from infection. Knowledge of the roles of AMPs in immune responses will contribute to improved understanding and treatment of the pathophysiology of human diseases, including inflammatory bowel disease, sexually transmitted and opportunistic infections, atopic dermatitis, and others. The program will be divided into 9 sessions of oral presentations and four poster sessions. The conference is co-chaired by Drs. Nita Salzman and Gill Diamond, together with the co-vice-chairs, Drs. Julia Dorin and Pieter Hiemstra, and will open with a keynote address presented by Professor Jules Hoffmann. Special attention will be made to include junior faculty and student participants. Speakers will include those selected in advance based on recent important discoveries, and those selected from submitted abstracts. Session topics will include: Conservation of Antibacterial Host Defense; AMPs as Antivirals; Host Defense against Fungi and Parasites; Cyclic AMPs; AMPs at the Interface; Antimicrobial and Beyond; AMPs and Immunity; and Novel Technologies and Applications for AMPs. Ample time for organized discussion and informal interactions between participants has been included. In addition, daily sessions, including "Hot Corner and Late Breaking News" will be devoted to discussing topics at the cutting edge of current investigation. The organizational philosophy is to encourage diverse participation, and maintain an eye towards gender issues, junior scientists, minorities, and individuals with physical limitations.