Joint Initiative in Vaccine Economics, Phase 4

项目总结 意义：随着新疫苗的出现，疫苗经济学研究的需求将会增加，因为 疫苗接种计划的预算限制。这项研究的目的是为疫苗政策提供信息 免疫做法咨询委员会(ACIP)、疾控中心、 以及其他州和地方决策者。 具体目标：拟议的研究涉及疫苗政策中的关键问题：(1)潜在的健康和 扩大疫苗接种覆盖面的经济效益；(2)疫苗风险与效益权衡的社会价值；以及 (3)公众对青少年和成人疫苗接种设置的偏好。 调查人员和环境：此应用程序要求持续支持非常成功的 疫苗经济学联合倡议(疫苗经济学联合倡议)，现已进入第十个年头。摇摆舞项目 包括在广泛的经济评估和决策科学领域具有广泛经验的调查人员 方法包括成本-效果分析、效益-成本分析、条件价值评估和联合 分析，以及建模方法方面的相关专业知识。疫苗经济学的联合倡议有一个 支持哈佛大学合作研究人员合作研究的悠久历史 以及疾病控制和预防中心(CDC)。 创新和研究战略：总体方法是使用经济和决策分析方法来 为疫苗政策决策提供依据。初步研究将衡量 疫苗接种覆盖面对健康结果、成本和成本效益的变化，通过制定 美国疫苗接种经济价值的理论模型和动态经验模型 仿真建模。我们建议就预计具有较高政策影响的主题进行另外两项研究：风险-- 疫苗接种相关不良事件的利益权衡；成人疫苗接种的障碍和促进者。这个 提出的方法借鉴了经济和建模方法，包括动态模拟模型， 尚未广泛应用于疫苗政策的多准则决策分析和联合分析 问题。研究小组将与疾控中心的调查人员共同确定与政策相关的主题，并 制定适当的研究计划。

PROJECT SUMMARY Significance: As new vaccines become available, the need for vaccine economics research will increase due to budget constraints for vaccination programs. The objective of this research study is to inform vaccine policy recommendations under consideration by the Advisory Committee for Immunization Practices (ACIP), CDC, and other state and local decision makers. Specific Aims: The proposed research studies addresses key issues in vaccine policy: (1) potential health and economic benefits of improved vaccination coverage; (2) societal values for vaccine risk-benefit tradeoffs; and (3) public preferences for adolescent and adult vaccination settings. Investigators and Environment: This application requests continued support for a highly successful collaboration, the Joint Initiative in Vaccine Economics (JIVE), which is now in its tenth year. The JIVE project includes investigators with broad experience in a wide range of economic evaluation and decision science methods including cost-effectiveness analysis, benefit-cost analysis, contingent valuation, and conjoint analysis, as well as related expertise in modeling methods. The Joint Initiative in Vaccine Economics has a long history of supporting collaborative research among co-investigators at Harvard University, the University of Michigan, and the Centers for Disease Control and Prevention (CDC). Innovation and Research Strategy: The overall approach is to use economic and decision analysis methods to provide evidence to inform vaccine policy decisions. The initial study will measure the economic value of changes in vaccination coverage on health outcomes, costs, and cost-effectiveness, by developing a theoretical model of the economic value of vaccination for the US and an empirical model using dynamic simulation modeling. We propose two additional studies on topics anticipated to have high policy impact: risk- benefit tradeoffs for vaccination-related adverse events; barriers and facilitators to adult vaccination. The proposed methods draw on economic and modeling approaches, including dynamic simulation models, multiple-criteria decision analysis, and conjoint analysis, that have not been widely applied to vaccine policy questions. Jointly with investigators from CDC, the research team will identify topics of policy relevance and develop the appropriate research plan.