Influenza and Other Emerging Infectious Diseases in Vietnam (U01)

描述(申请人提供)：越南对人和动物流感的研究将为设计和实施预防、控制和治疗战略和政策提供重要的新信息，以减少越南及其邻国的流感感染、疾病和死亡，并将有助于及早发现、治疗、控制和遏制可能在全球传播的流感病毒。该建议包括5个针对具体公布目的和目标的子项目研究：1)越南人和动物甲型流感病毒的共同进化，包括流行的人类季节性毒株以及高致病性动物毒株，包括禽流感A/H5N1病毒，使用基因组测序、生物信息学方法从越南各地的人和动物分离的病毒分离；2)越南人甲型H5N1流感的流行病学：2003-2008年108例确诊病例的回顾统计回顾和单因素分析；3)越南人的甲型H5N1流感流行病学：感染和疾病风险因素的病例对照研究；4)越南选定的3家地区医院流感相关急性下呼吸道感染(ALRTI)的负担；5)在越南开发改进的人类流感诊断方法，特别是对一种新的改进方法的试点评估，该方法用于在护理地点快速识别A/H3、H1、H5病毒亚型。

DESCRIPTION (provided by applicant): Research on human and animal influenza in Vietnam will provide new information important in the design and implementation of prevention, control, and treatment strategies and policies required to reduce infection, illness and death from influenza in Vietnam and neighboring countries and will assist in the early detection, treatment, control, and containment of influenza viruses having potential for global spread. The proposal comprises 5 subproject studies that address specific announcement aims and objectives: 1) Co-evolution of human and animal Influenza A viruses, Vietnam, including circulating human seasonal strains as well as highly pathogenic animal strains, including avian influenza A/H5N1 viruses, using genomic sequencing, bioinformatics methods on virus isolates from humans and animals throughout Vietnam; 2) Epidemiology of Influenza A/H5N1 in humans, Vietnam: retrospective summary statistical review and univariate analyses of 108 confirmed cases, 2003-2008; 3) Epidemiology of Influenza A/H5N1 in humans, Vietnam: case-control study of risk factors for infection and disease; 4) Burden of influenza-related acute lower respiratory tract infection (ALRTI) in 3 selected district hospitals, Vietnam; 5) Development of improved methods for the diagnosis of influenza in humans in Vietnam, especially the pilot evaluation of a new and improved method for rapid antigenic identification of A/H3,H1,H5 virus subtypes at point-of-care.