Influenza and Other Emerging Infectious Diseases in Vietnam (U01)

越南的流感和其他新发传染病 (U01)

• 批准号: 7777018
• 负责人: HIEN TRAN NGUYEN
• 金额: $ 40万
• 依托单位: NATIONAL INSTITUTE HYGIENE/EPIDEMIOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7777018
• 关键词: Influenza; Other; Emerging; Infectious; Diseases

DESCRIPTION (provided by applicant): Research on human and animal influenza in Vietnam will provide new information important in the design and implementation of prevention, control, and treatment strategies and policies required to reduce infection, illness and death from influenza in Vietnam and neighboring countries and will assist in the early detection, treatment, control, and containment of influenza viruses having potential for global spread. The proposal comprises 5 subproject studies that address specific announcement aims and objectives: 1) Co-evolution of human and animal Influenza A viruses, Vietnam, including circulating human seasonal strains as well as highly pathogenic animal strains, including avian influenza A/H5N1 viruses, using genomic sequencing, bioinformatics methods on virus isolates from humans and animals throughout Vietnam; 2) Epidemiology of Influenza A/H5N1 in humans, Vietnam: retrospective summary statistical review and univariate analyses of 108 confirmed cases, 2003-2008; 3) Epidemiology of Influenza A/H5N1 in humans, Vietnam: case-control study of risk factors for infection and disease; 4) Burden of influenza-related acute lower respiratory tract infection (ALRTI) in 3 selected district hospitals, Vietnam; 5) Development of improved methods for the diagnosis of influenza in humans in Vietnam, especially the pilot evaluation of a new and improved method for rapid antigenic identification of A/H3,H1,H5 virus subtypes at point-of-care. PUBLIC HEALTH RELEVANCE: Seasonally circulating human influenza strains are a major cause of illness in Vietnam, and are also an important cause of excess deaths based on knowledge from countries where the disease has been more thoroughly studied. Infection of humans and animals with the highly pathogenic avian influenza virus (A/H5N1) has since 2003 caused a huge public health and economic burden on Vietnam, resulting in the loss of over 50 million poultry and 108 human cases and 52 case deaths. There is a high global concern that viruses circulating in Vietnam could through genetic mutation or re-assortment result in rapid global spread of a new and highly pathogenic strain of virus potentially causing a global emergency with 50 million or more deaths and severe socioeconomic disruptions. A better understanding of the virus evolution, risk factors for infection, the epidemiologic characteristics of influenza illness in communities and its burden, and the development and evaluation of new and improved diagnostic test methods can lead to improved influenza treatment, prevention, control and containment, including for avian and pandemic influenza.

描述（由申请人提供）：越南的人类和动物流感研究将为设计和实施预防、控制和治疗策略和政策提供重要的新信息，以减少越南和邻国的流感感染、疾病和死亡，并将有助于早期发现、治疗、控制和遏制可能在全球传播的流感病毒。 该提案包括5个子项目研究，涉及具体的公告目的和目标：1）越南人类和动物甲型流感病毒的共同进化，包括流行的人类季节性毒株以及高致病性动物毒株，包括禽流感A/H5 N1病毒，使用基因组测序和生物信息学方法对越南各地人类和动物的病毒分离株进行研究; 2）越南人类感染甲型/H5 N1流感的流行病学：2003-2008年108例确诊病例的回顾性汇总统计审查和单变量分析; 3）越南人类感染甲型/H5 N1流感的流行病学：感染和疾病风险因素的病例对照研究; 4）越南3个选定地区医院流感相关急性下呼吸道感染（ALRTI）的负担; 5）在越南开发人类流感诊断的改进方法，特别是对A/H3抗原快速鉴定的新方法和改进方法进行试点评估，即时检测H1、H5病毒亚型。 公共卫生相关性：季节性流行的人流感病毒株是越南的主要致病原因，也是根据对该疾病进行了更彻底研究的国家的知识造成死亡人数过多的重要原因。 自2003年以来，人类和动物感染高致病性禽流感病毒（A/H5 N1）给越南造成了巨大的公共卫生和经济负担，导致5000多万只家禽死亡，108例人类病例和52例死亡。 全球高度关注的是，在越南传播的病毒可能通过基因突变或重组导致一种新的高致病性病毒株在全球迅速传播，可能造成全球紧急情况，造成5000万人或更多人死亡，并造成严重的社会经济破坏。 更好地了解病毒进化、感染风险因素、社区流感疾病的流行病学特征及其负担，以及开发和评估新的和改进的诊断测试方法，可以改善流感的治疗、预防、控制和遏制，包括针对禽流感和大流行性流感。