High Resolution Photovoltaic Retinal Prosthesis

高分辨率光伏视网膜假体

• 批准号: 8477527
• 负责人: DANIEL V PALANKER
• 金额: $ 113.37万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8477527
• 关键词: Address; Animal Model; Animals; Behavioral; Biocompatible; Blindness; Characteristics; Clinical; Complex; Contrast Sensitivity; Degenerative Disorder; Development; Discrimination; Electrodes; Electronics; Electrophysiology (science); Engineering; Evaluation; Eye Movements; Frequencies; Generations; Goals; Goggles; Image; Implant; In Vitro; Lead; Left; Lighting; Link; Measures; Mediating; Methods; Monitor; Neurons; Operative Surgical Procedures; Ophthalmologist; Patients; Pattern; Perception; Performance; Photoreceptors; Physiologic pulse; Prosthesis; Rattus; Resolution; Retina; Retinal; Retinal Degeneration; Retinitis Pigmentosa; Safety; Silicon; Staging System; Stimulus; System; Systems Development; Testing; Time; Vision; Visual; Visual Acuity; Visual Fields; Visual Perception; Visual evoked cortical potential; Wireless Technology; biomaterial compatibility; density; design; electric field; follow-up; image processing; implantation; improved; in vivo; innovation; parylene; patch clamp; prevent; public health relevance; response; retinal prosthesis; retinal stimulation; silicon carbide; two-dimensional

DESCRIPTION (provided by applicant): Retinal degenerative diseases lead to blindness due to loss of the "image capturing" photoreceptor layer, while neurons in the "image processing" inner retinal layers are preserved to a large extent. Electronic retinal prostheses seek to restor sight by electrical pattern stimulation of surviving neurons. Very encouraging clinical results with the first retinal prostheses have been recently demonstrated. However, current implants are powered through inductive coils, requiring complex surgical methods to implant the coil-decoder-cable-array systems, which deliver energy to stimulating electrodes via intraocular cables. We developed a photovoltaic subretinal prosthesis, in which silicon photodiodes in each pixel directly convert pulsed near-infrared (NIR) images projected from video goggles into local electric currents to stimulate neurons. This system offers multiple advantages over other designs: due to wireless activation of the pixels in the implant the system is scalable to thousands of electrodes; it maintains the natural link between eye movements and image perception; the implantation is greatly simplified and modular design of the implant allows expanding the visual field by tiling; pillar electrodes allow cellular-scale proximity to the targe neurons. Such a versatile system could be used to address the divergent needs of patients with various forms of retinal degeneration. We have manufactured and tested the first generation of the implants. Photovoltaic arrays show long-term biocompatibility, and provide safe retinal stimulation upon illumination with NIR pulses in-vitro and in-vivo. We now seek to produce the implants designed for highest resolution and lowest stimulation thresholds, and protected by inert and biocompatible coatings for long-term implantations. To achieve these goals we will assess visual acuity and contrast sensitivity obtained with subretinal photovoltaic implants of different designs in-vitro and in-vivo in animals with normal and degenerate retinas. This project brings together a unique combination of engineers, neuroscientists and ophthalmologists to complete the development and evaluation of a high-resolution retinal prosthetic system designed specifically for achieving the functional levels of vision.

描述（申请人提供）：视网膜退行性疾病由于“图像捕获”感光层的丧失而导致失明，而“图像处理”视网膜内层的神经元在很大程度上被保留。电子视网膜假体试图通过电刺激存活的神经元来恢复视力。最近，第一批视网膜假体的临床结果非常令人鼓舞。然而，目前的植入物是通过感应线圈供电的，需要复杂的手术方法来植入线圈-解码-电缆阵列系统，该系统通过眼内电缆向刺激电极传递能量。我们开发了一种光伏视网膜下假体，其中每个像素上的硅光电二极管直接将从视频护目镜投射的脉冲近红外（NIR）图像转换为局部电流以刺激神经元。与其他设计相比，该系统具有多种优势：由于植入物中像素的无线激活，该系统可扩展到数千个电极；它维持眼球运动和图像感知之间的自然联系；植入物大大简化，植入物的模块化设计允许通过平铺扩展视野；柱状电极可以在细胞尺度上接近目标神经元。这样一个多功能的系统可以用来解决不同形式的视网膜变性患者的不同需求。我们已经制造并测试了第一代植入物。光伏阵列具有长期的生物相容性，并在体外和体内近红外脉冲照射下提供安全的视网膜刺激。我们现在寻求生产具有最高分辨率和最低刺激阈值的植入物，并由惰性和生物相容性涂层保护，用于长期植入。为了实现这些目标，我们将评估不同设计的视网膜下光伏植入物在体外和体内对正常和退化视网膜动物的视力和对比灵敏度。这个项目