Optoretinography: All-optical measures of functional activity in the human retina

视网膜检光术：人类视网膜功能活动的全光学测量

• 批准号: 10869100
• 负责人: DANIEL V PALANKER
• 金额: $ 16.12万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10869100
• 关键词: Acceleration; Administrative Supplement; Area; Biological Markers; Biomedical Engineering; Clinical; Clinical Research; Collaborations; Compensation; Cone; Consent; Databases; Dedications; Densitometry; Development; Diagnosis; Disease; Elements; Eye; Friends; Generations; Genotype; Goals; Human; Image; In Situ; Individual; Inherited; Interferometry; Light; Maintenance; Measurement; Measures; Methods; Molecular; Monitor; Motion; Natural regeneration; Optics; Patient Recruitments; Patients; Persons; Phase; Phenotype; Photosensitivity; Phototransduction; Pigments; Positioning Attribute; Protocols documentation; Rattus; Research; Research Infrastructure; Resolution; Responsible Person; Retina; Retinal Diseases; Retinitis Pigmentosa; Rodent; Schedule; Signal Transduction; Standardization; System; Technology; Testing; Therapeutic Intervention; Time; Tissues; Treatment Efficacy; Universities; Variant; Visual System; adaptive optics; arm; clinical translation; human subject; improved; in vivo; neural; neuron regeneration; parent grant; payment; recruit; response; retinal neuron; synergism; therapeutic evaluation; tool; visual processing; visual tracking

Project Summary/Abstract The optoretinogram (ORG) holds great promise as a probe of cone function in normal eyes, in the assessment of disease states of cones in disease, and in the evaluation of therapeutic interventions. To achieve its promise, the cellular and molecular basis of the ORG needs to be established, and methods standardized for application in the clinical setting. This supplement will pursue research opportunities that have opened up under the current Bioengineering research partnership, but were previously unforeseen. These include the addition of adaptive optics to rodent optoretinography in order to improve signal fidelity and resolution at Stanford University. Second, in a collaborative effort between UC Davis and UW, a key discrepancy was discovered previously in all extant measures of pigment bleaching; this supplement will aim to resolve this issue and elucidate the mechanistic basis of the cone ORG. Lastly, the rapid development of a patient-friendly variant of the ORG at UW has accelerated the recruitment of patients with inherited retinal disease, and created an opportunity to standardize the ORG protocols for studying genotype-phenotype correlations in a clinical setting. Support from the supplement will provide an avenue to explore these three unanticipated, exciting and critical areas, thus providing synergy to the clinical, technological and mechanistic facets of the project.

项目总结/文摘

项目成果

Optoretinography is coming of age.

视网膜检光术正在成熟。

• DOI: 10.1073/pnas.2119737118
• 发表时间: 2021
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Roorda,Austin