SEQUENCE OF SYMPTOM CHANGE DURING AUD OR PTSD TREATMENT FOR COMORBID PTSD/AUD

合并 PTSD/AUD 的 AUD 或 PTSD 治疗期间症状变化的顺序

基本信息

  • 批准号:
    8423703
  • 负责人:
  • 金额:
    $ 53.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-02-10 至 2017-01-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid PTSD and alcohol abuse and dependence (AUD). Prior research has established that PTSD and AUD are frequently comorbid. Although combined treatments have been developed, they are complex and lengthy with mixed results as to their efficacy. Excellent treatments exist for PTSD or AUD alone, however, it has not been adequately addressed to what extent these treatments are effective in treating comorbid symptom presentations. To address this research gap, we will evaluate two widely accepted treatments for each respective disorder; Cognitive Processing Therapy (CPT) an effective PTSD treatment and Relapse Prevention (RP), a widely used effective AUD treatment. The purpose of the present application is to evaluate changes in both PTSD symptoms and alcohol use and cravings associated with CPT or RP treatment in individuals with PTSD/AUD, along with mediators and moderators of outcomes. We will build on our prior work using a daily telephone Interactive Voice Response (IVR) system to test models of self-medication and the sequence of symptom change for both primary and secondary symptom targets associated with each therapy with. The study will randomize 235 PTSD/AUD participants recruited from the VA and from the community to CPT, RP, or IVR assessment only (AO). Those in the AO condition will be re-randomized after the treatment phase to either RP or CPT. Individuals will be assessed pretreatment, immediately post-treatment, 3-, 6-, 9-, and 12-months post-treatment and will monitor symptoms daily throughout treatment. Creating a more comprehensive model of symptom change in PTSD and alcohol use with widely used selective treatments is critical in testing theories of PTSD/AUD, evaluating these treatments for use with PTSD/AUD, and implementing these therapies with PTSD/AUD patients in standard clinical practice.
描述(由申请人提供):当前研究的广泛、长期目标是改善患有PTSD合并酒精滥用和依赖(AUD)的个体的治疗结果。先前的研究已经确定PTSD和AUD经常是合并症。虽然已经开发出联合治疗方法,但它们复杂且耗时长,疗效好坏参半。目前仅对PTSD或AUD有很好的治疗方法,然而,这些治疗方法在多大程度上有效治疗共病症状表现还没有得到充分的解决。为了解决这一研究空白,我们将评估两种被广泛接受的治疗方法;认知加工疗法(CPT)是一种有效的PTSD治疗方法,而复发预防(RP)是一种被广泛应用的有效的AUD治疗方法。本应用的目的是评估PTSD/AUD患者在CPT或RP治疗后PTSD症状、酒精使用和渴望的变化,以及结果的调节因子和调节因子。我们将在之前工作的基础上,使用每日电话交互式语音应答(IVR)系统来测试自我药物治疗模型以及与每种治疗相关的主要和次要症状目标的症状变化顺序。该研究将随机从VA和社区招募235名PTSD/AUD参与者,仅进行CPT, RP或IVR评估(AO)。在治疗阶段后,AO患者将被重新随机分配到RP或CPT组。在治疗前、治疗后立即、治疗后3个月、6个月、9个月和12个月对个体进行评估,并在整个治疗过程中每天监测症状。在广泛使用的选择性治疗中,创建一个更全面的PTSD和酒精使用症状变化模型,对于检验PTSD/AUD理论、评估这些治疗方法在PTSD/AUD患者中的应用以及在标准临床实践中实施这些治疗方法至关重要。

项目成果

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会议论文数量(0)
专利数量(0)

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DEBRA L KAYSEN其他文献

DEBRA L KAYSEN的其他文献

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{{ truncateString('DEBRA L KAYSEN', 18)}}的其他基金

A Promotora-centric Community Collaborative to Improve Connections to Mental Health Services
以 Promotora 为中心的社区合作,以改善与心理健康服务的联系
  • 批准号:
    10597930
  • 财政年份:
    2022
  • 资助金额:
    $ 53.4万
  • 项目类别:
A Promotora-centric Community Collaborative to Improve Connections to Mental Health Services
以 Promotora 为中心的社区合作,以改善与心理健康服务的联系
  • 批准号:
    10706423
  • 财政年份:
    2022
  • 资助金额:
    $ 53.4万
  • 项目类别:
Preventing HIV among Native Americans through the treatment PTSD & substance use
通过治疗创伤后应激障碍 (PTSD) 预防美洲原住民艾滋病毒
  • 批准号:
    9127517
  • 财政年份:
    2016
  • 资助金额:
    $ 53.4万
  • 项目类别:
Preventing HIV among Native Americans through the treatment PTSD & substance use
通过治疗创伤后应激障碍 (PTSD) 预防美洲原住民艾滋病毒
  • 批准号:
    9974562
  • 财政年份:
    2016
  • 资助金额:
    $ 53.4万
  • 项目类别:
Preventing HIV among Native Americans through the treatment PTSD & substance use
通过治疗创伤后应激障碍 (PTSD) 预防美洲原住民艾滋病毒
  • 批准号:
    9360567
  • 财政年份:
    2016
  • 资助金额:
    $ 53.4万
  • 项目类别:
SEQUENCE OF SYMPTOM CHANGE DURING AUD OR PTSD TREATMENT FOR COMORBID PTSD/AUD
合并 PTSD/AUD 的 AUD 或 PTSD 治疗期间症状变化的顺序
  • 批准号:
    8797288
  • 财政年份:
    2012
  • 资助金额:
    $ 53.4万
  • 项目类别:
SEQUENCE OF SYMPTOM CHANGE DURING AUD OR PTSD TREATMENT FOR COMORBID PTSD/AUD
合并 PTSD/AUD 的 AUD 或 PTSD 治疗期间症状变化的顺序
  • 批准号:
    8234473
  • 财政年份:
    2012
  • 资助金额:
    $ 53.4万
  • 项目类别:
SEQUENCE OF SYMPTOM CHANGE DURING AUD OR PTSD TREATMENT FOR COMORBID PTSD/AUD
合并 PTSD/AUD 的 AUD 或 PTSD 治疗期间症状变化的顺序
  • 批准号:
    8599740
  • 财政年份:
    2012
  • 资助金额:
    $ 53.4万
  • 项目类别:
High Risk Drinking in Emerging Adult at Risk Women
新兴成年高危女性的高风险饮酒
  • 批准号:
    8051787
  • 财政年份:
    2010
  • 资助金额:
    $ 53.4万
  • 项目类别:
High Risk Drinking in Emerging Adult at Risk Women
新兴成年高危女性的高风险饮酒
  • 批准号:
    8243692
  • 财政年份:
    2010
  • 资助金额:
    $ 53.4万
  • 项目类别:

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