Health behaviors over the adult lifecourse and cognitive aging

项目摘要 成年期健康行为与认知老化 越来越多的证据表明健康行为与认知老化之间存在关联。吸烟， 酒精、体力活动和营养都被发现与认知功能低下有关， 痴呆健康行为在多大程度上可以解释认知老化的轨迹， 健康相关性，特别是因为它们可能是痴呆症的关键可改变风险因素。总体 这项建议的目的是研究健康行为对成年人生命过程的综合影响， 确定从中年开始的认知老化轨迹。具体目标是： 1.研究吸烟、饮酒、体育活动和饮食对认知功能的综合影响， 下降，以评估健康行为在中年早期，中期和晚期的影响是否最大 重要的是，这种影响是否会随着时间的推移而积累。 2.研究一种行为的变化在多大程度上导致了其他行为的变化， 这些变化影响认知老化。 3.研究健康行为与中年开始的认知老化之间的双向关联： 4.为了检查生物变化的程度，如血管危险因素和疾病， 解释健康行为和认知老化之间的联系。我们还将研究 健康行为和认知老化之间的关联的两个潜在效应修饰符： 社会经济地位（SES）和载脂蛋白E（APOE）e4等位基因。 此外，我们的工作将集中在健康行为测量的问题上： 健康行为的分类，以了解每一个之间的关联的形状， 行为和认知老化的措施，是否不同的措施饮食有类似的关联， 认知老化以及客观和主观测量之间是否存在差异， 体力活动。我们还将研究健康行为对认知老化特定领域的影响， 记忆和执行功能是两个主要方面。 白厅II测试组合在第5阶段被介绍给整个白厅II队列，当时参与者 平均年龄55岁，在过去的10年里已经进行了行为评估。第三波 目前正在收集认知数据，并将在2009年底提供，使我们能够看到的轨迹， 认知改变虽然该提议主要基于英国白厅，但研究团队在 由法国和英国的科学家组成，为我们提供了验证一些 法国GAZEL研究的数据。

PROJECT SUMMARY Health behaviors over the adult lifecourse and cognitive aging There is increasing evidence of an association between health behaviors and cognitive aging. Smoking, alcohol, physical activity and nutrition have all been found to be associated with poor cognitive function and dementia. The extent to which health behaviors can explain cognitive aging trajectories is of substantial public health relevance, particularly as they may be 'the' key modifiable risk factors for dementia. The overarching aim of this proposal is to examine the combined impact of health behaviors over the adult lifecourse in determining cognitive aging trajectories starting from midlife. The specific aims are: 1. To examine the combined impact of smoking, alcohol consumption, physical activity and diet on cognitive decline in order to assess whether the impact of health behaviors in early, mid and late midlife is most important and whether this effect accumulates over time. 2. To examine the extent to which change in one behavior leads to changes in others and the extent to which these changes influence cognitive aging. 3. To examine bidirectional associations between health behaviors and cognitive aging starting in midlife: 4. To examine the extent to which biological changes, such as those in vascular risk factors and diseases, explain the association between health behaviors and cognitive aging. We will also examine the role played by two potential effect modifiers of the association between health behaviors and cognitive aging: socioeconomic status (SES) and the apolipoprotein E (APOE) e4 allele. In addition, our work will focus on issues to do measurement of health behaviors: Detailed attention will be paid to the categorization of the health behaviors in order to understand the shape of the association between each measure of behavior and cognitive aging, whether different measures diet have similar associations with cognitive aging and whether there are discrepancies between the objective and subjective measures of physical activity. We will also examine the impact of health behaviors on specific domains of cognitive aging, with memory and executive function as two major aspects. The Whitehall II test battery was introduced to the full Whitehall II cohort at phase 5 when participants were on average 55 years old and had already been assessed for behaviors over the previous 10 years. A third wave of cognitive data is currently being collected, and will be available late 2009, allowing us look at trajectories of cognitive change. Although the proposal is based primarily on the British Whitehall, the research team is composed of scientists based in France as well as the UK, providing us with the opportunity to validate some of our results in data from the French GAZEL study.