The role of trauma in HIV transmission, acquisition and pathogenesis

创伤在艾滋病毒传播、获得和发病机制中的作用

• 批准号: 8548785
• 负责人: Judith D. Auerbach
• 金额: $ 0.6万
• 依托单位: SOCIAL SCIENCE RESEARCH COUNCIL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8548785
• 关键词: AIDS prevention; Address; Adopted; Agreement; Anal Injury; Anal Sex; Area; Case Study; Characteristics; Clinical Services; Clinical Trials; Counseling; Country; Data; Data Analyses; Data Collection; Development; Epidemic; Funding; Gender; HIV; Heterosexuals; Interdisciplinary Study; International; Intervention; Journals; Manuscripts; Methodology; Modeling; Pathogenesis; Peer Review; Physiological; Policies; Population; Prevalence; Prevention; Preventive Intervention; Process; Publications; Relative (related person); Research; Research Infrastructure; Research Priority; Resistance; Risk; Risk Behaviors; Role; Scientific Advances and Accomplishments; Series; Site; Social Problems; Trauma; Typology; United States National Institutes of Health; Vagina; Variant; Violence; Vocabulary; base; design; high risk; improved; meetings; prevent; public health relevance; screening; sexual violence; social; transmission process; violence prevention

DESCRIPTION (provided by applicant): This application proposes to establish an interdisciplinary and international research team and agenda and strategy for improving understanding about the role of sexual violence and genito- anal injury in HIV transmission, acquisition and pathogenesis. Funding is sought for a series of three scientific meetings to advance the scientific research priorities emerging from the Greentree Scientific Research Planning Meeting on Sexual Violence, Genito-anal Injury and HIV Transmission. This unique interdisciplinary gathering, convened by the SSRC with support from UNAIDS and the NIH, identified physiological and social co-factors of sexual violence that are understudied but potentially significant for understanding epidemic's disproportionate geographic and gender distribution. The meetings will provide an opportunity to develop an interdisciplinary research team and agenda with a shared conceptual and methodological framework that can overcome the disciplinary-specific approaches that have been unsuccessful in tackling an inherently bio- social problem. The process will result in a workable research plan for carrying out the exploratory and developmental research needed to address the methodological and feasibility questions arising during the planning process. The aim is to identify the most critical areas of needed data collection that are likely to have a significant impact on the field and begin to signa directions for prioritizing interventions. The plan will also seek to inform the USG National Strategy to Prevent and Respond to Gender Based Violence, adopted in August2012, and PEPFAR's GBV strategy which seeks to close gaps in countries where systematic gender-based violence prevalence data has not been collected/ Increased understanding about the relative contribution of genito-anal injury to important predictive variables such a 'risk behavior and 'modes of exposure' and 'high and low risk heterosexual transmission' will improve understanding about the social drivers that influence unprotected heterosexual vaginal and anal sex. Increased understanding about the distribution of HIV among sub-populations that are at highest risk of sexual violence will improve the design and prioritizing of combination prevention interventions that are most likely to reduce the risk of sexual violence and its potential contribution to HIV transmission.

描述(由申请人提供)：本申请建议建立一个跨学科和国际研究团队以及议程和战略，以提高对性暴力和生殖器肛门损伤在艾滋病毒传播、感染和发病中的作用的了解。为一系列三次科学会议寻求资金，以推进格林特里科学研究规划会议关于性暴力、生殖器肛门损伤和艾滋病毒传播的科学研究优先事项。在艾滋病规划署和国立卫生研究院的支持下，SSRC召集了这次独特的跨学科会议，确定了性暴力的生理和社会共同因素，这些因素尚未得到充分研究，但对于了解流行病不成比例的地理和性别分布可能具有重要意义。这些会议将提供一个机会，以发展一个跨学科研究小组和议程，建立一个共享的概念和方法框架，以克服在解决生物-社会固有问题方面不成功的具体学科方法。这一进程将产生一项可行的研究计划，以便开展必要的探索性和发展性研究，以解决规划过程中出现的方法和可行性问题。其目的是确定可能对实地产生重大影响的所需数据收集中最关键的领域，并开始为确定干预措施的优先次序指明方向。该计划还将寻求为美国政府于2012年8月通过的预防和应对基于性别的暴力的国家战略以及PEPFAR的GBV战略提供信息，该战略寻求在尚未收集系统的基于性别的暴力流行数据的国家弥合差距/增加对生殖器-肛门损伤对重要预测变量的相对贡献的了解，如“风险行为和暴露方式”以及“高风险和低风险的异性传播”，这将提高对影响无保护措施的异性阴道和肛门性行为的社会驱动因素的理解。增进对艾滋病毒在性暴力风险最高的亚人群中分布的了解，将改进最有可能减少性暴力风险及其对艾滋病毒传播的潜在贡献的组合预防干预措施的设计和优先次序。

项目成果

Sexual violence and HIV transmission: summary proceedings of a scientific research planning meeting.

性暴力与艾滋病毒传播：科学研究规划会议摘要。

• DOI: 10.1111/aji.12033
• 发表时间: 2013
• 期刊: American journal of reproductive immunology (New York, N.Y. : 1989)
• 作者: Klot,JenniferF;Auerbach,JudithD;Berry,MirandaR
• 通讯作者: Berry,MirandaR