FASEB SRC: Genetic Recombination and Genome Rearrangements

FASEB SRC：基因重组和基因组重排

• 批准号: 8525768
• 负责人: Wolf-Dietrich Heyer
• 金额: $ 0.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8525768
• 关键词: Adverse effects; American; BRCA1 gene; BRCA2 gene; Biological; Biological Markers; Biology; Cancer Etiology; Cancer-Predisposing Gene; Colorado; DNA Damage; DNA Double Strand Break; DNA Repair; DNA Sequence Rearrangement; Equilibrium; Gene Proteins; Genetic Models; Genetic Recombination; Genome; Human; Immune System Diseases; Information Technology; Knowledge; Malignant Neoplasms; Modality; Neurologic; Participant; Pathway interactions; Pharmaceutical Preparations; Premature aging syndrome; Principal Investigator; Process; Radiation; Regulation; Research; Research Personnel; Role; Series; Societies; Syndrome; System; Techniques; Tumor Suppressor Genes; biological systems; cancer therapy; chemotherapy; crosslink; improved; insight; malignant breast neoplasm; new technology; next generation sequencing; novel strategies; programs; public health relevance; recombinational repair; repaired; symposium; unpublished works

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 21-26, 2013 in Steamboat Springs, Colorado. The 2013 Conference will be the fifteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. DNA Recombination and Genome Rearrangements have a two-fold significance for cancer. First, many genes/proteins involved in the mechanisms and regulation of recombination have already been identified as tumor suppressor genes. Hence, studies with these genes/proteins are paramount for an improved understanding of the etiology of cancer and to develop critical biomarkers. Second, induction of systemic or localized DNA damage by chemotherapy or radiation, respectively constitute major modalities of anti-cancer treatment. The types of relevant DNA damages include DNA double-stranded breaks and interstrand crosslinks, and recombination is a central cellular pathway to repair such damage. Therefore, increased knowledge on the regulation and mechanism of these repair processes will also inform novel strategies of anti-cancer treatment leading to more efficacious treatment. Several timely issues will be discussed, including the role of the breast cancer susceptibility gene BRCA2 in the control of recombination and the role of recombination in repair of DNA damage caused by cancer treatment relevant drugs and radiation. Characterization of recombination and repair factors known to underlie human syndromes with propensity to cancer, premature aging, immune dysfunction and neurological degeneration will also be discussed, using mammalian and other model genetic systems. In addition, new insights from next generation sequencing approaches will be discussed. By emphasizing truly exceptional research in a modestly sized conference setting, the FASEB conference provides unique opportunities for the exchange of information, technology and perspective among new and established investigators in the recombination field.

描述（由申请人提供）：本申请寻求对将于2013年7月21-26日在科罗拉多的汽船泉举行的美国实验生物学学会联合会（FASEB）遗传修饰和基因组重排会议的部分支持。2013年会议将是专门讨论这些主题的一系列非常成功的半年期会议中的第十五次会议。本次会议的目的是加入研究遗传重组的许多不同方面的研究人员，在一系列生物系统和不同的实验方法。演讲将介绍关于该领域及时问题的新的和未发表的工作，并将包括所有与会者的讨论。FASEB会议为信息和技术的交流提供了独特的机会，这些信息和技术可以在重组领域得到赞赏和利用。DNA扩增和基因组重排对癌症有双重意义。首先，参与重组机制和调控的许多基因/蛋白质已经被鉴定为肿瘤抑制基因。因此，对这些基因/蛋白质的研究对于提高对癌症病因的了解和开发关键生物标志物至关重要。其次，通过化疗或放疗诱导全身或局部DNA损伤分别构成抗癌治疗的主要方式。相关DNA损伤的类型包括DNA双链断裂和链间交联，重组是修复此类损伤的中心细胞途径。因此，增加对这些修复过程的调节和机制的了解也将为抗癌治疗的新策略提供信息，从而导致更有效的治疗。将讨论几个及时的问题，包括乳腺癌易感基因BRCA 2在重组控制中的作用，以及重组在修复癌症治疗相关药物和辐射引起的DNA损伤中的作用。重组和修复因子的特征，已知的基础人类综合征与癌症的倾向，过早衰老，免疫功能障碍和神经退行性疾病也将讨论，使用哺乳动物和其他模型遗传系统。此外，还将讨论下一代测序方法的新见解。通过强调在一个适度规模的会议环境中进行真正卓越的研究，FASEB会议为重组领域的新老研究人员之间交流信息，技术和观点提供了独特的机会。