2015 Nucleic Acids Gordon Research Conference

 描述(申请人提供)：本申请寻求对将于2015年5月31日至6月5日在缅因州比德福德的新英格兰大学举行的核酸戈登研究会议的部分支持。戈登核酸研究会议成立于50多年前，是介绍和讨论核酸生物学基本发现的主要论坛，这些发现几乎影响了生物学的方方面面，对人类健康有广泛的影响，特别是癌症。这次会议的总体长期目标是通过将世界领先的研究人员与初级科学家聚集在一起，创造一个有利于跨学科讨论和新思想交流的科学环境，以加强我们对核酸在生物学、人类健康和疾病中的作用的了解。这次会议的具体目标是召集34名涵盖该领域不同新兴领域的主要专家，共150名与会者，主要由研究生和博士后研究员组成，会议为期五天。2015年的核酸GRC会议将重点介绍DNA和RNA生物学在八个广泛分类的核酸研究领域的最新进展，以期突出这些领域的新兴概念和技术。具体主题包括：同源重组机制；DNA复制和基因组完整性；RNA/DNA结构和动力学；染色质和转录；RNA/DNA在细胞防御中的作用；转录后调控；RNA/DNA冲突；非编码RNA；以及端粒结构和功能。这一提议的意义在于，核酸戈登研究会议在将RNA和DNA领域聚集在一起方面是独一无二的，2015年的会议将特别强调RNA和DNA生物学之间的新兴接口，例如DNA复制过程中R-环或rNTP掺入对基因组稳定性和癌症的影响。此外，会议还展示了最新的技术进步，包括单分子方法和普遍适用的基因组工程CRISPR/CAS9技术。特别强调鼓励青年科学家出席并出席这次会议，时间表中特别分配了充足的时间进行简短演讲，这些演讲是从提交的摘要和4次海报会议中挑选出来的。这项提议的健康相关性和癌症相关性在于RNA和DNA生物学对人类疾病，特别是癌症的基本意义。2015年的会议将在一定程度上强调基因组的稳定性，DNA修复的潜在过程对癌症在抑制肿瘤和抗癌治疗方面具有双重意义。几个受邀的演讲集中在癌症易感性综合征，如范可尼贫血，并讨论对肿瘤抑制、诊断和治疗包括癌症在内的人类疾病至关重要的基因、过程和技术。

 DESCRIPTION (provided by applicant): This application seeks partial support for the Nucleic Acids Gordon Research Conference to be held May 31 - June 5, 2015, at the University of New England, Biddeford, Maine. The Gordon Research Conference on Nucleic Acids was established over 50 years ago and represents a premier forum to present and discuss fundamental discoveries in nucleic acids biology, which have impacted nearly every facet of biology with wide ranging implications for human health, specifically cancer. The overarching long-term goal of this conference is to create a scientific environment conducive to cross-disciplinary discussion and exchange of new ideas by bringing together the world's leading researchers with junior scientists, to enhance our understanding of the role of nucleic acids in biology, human health and disease. The Specific Aims of this meeting are to convene 34 leading experts that cover diverse and emerging areas within this field, with a total of 150 participants largely composed of graduate students and postdoctoral fellows, for a five-day meeting. The 2015 meeting of the Nucleic Acids GRC will highlight recent advances that encompass DNA and RNA biology in eight broadly classified areas of nucleic acids research with a view toward highlighting emerging concepts and technologies in these fields. Specific topics will include: Mechanisms of Homologous Recombination; DNA Replication and Genome Integrity; RNA/DNA Structure and Dynamics; Chromatin and Transcription; RNA/DNA in Cellular Defense; Post-transcriptional Regulation; RNA/DNA Conflicts; Non-Coding RNAs; and Telomere Structure and Function. The significance of this proposal is that the Nucleic Acids Gordon Research Conference is unique in bringing the RNA and DNA fields together, and the 2015 meeting will in particular highlight the emerging interfaces between RNA and DNA biology such as the impact of R-loops or rNTP incorporation during DNA replication on genome stability and cancer. Moreover, the conference showcases the latest technological advances, including single molecule approaches and the universally applicable CRISPR/Cas9 technology for genomic engineering. Particular emphasis is placed on encouraging young scientists to attend and present at this meeting, with ample time specifically allotted in the schedule for short talks selected from submitted abstracts and 4 poster sessions. The health relatedness and cancer relevance of this proposal lies in he fundamental significance of RNA and DNA biology for human disease and specifically cancer. The 2015 conference will have a certain emphasis on genome stability, where the underlying processes in DNA repair have dual significance for cancer in tumor suppression and anti-cancer therapy. Several invited talks center on cancer predisposition syndromes, such as Fanconi Anemia, and discuss genes, processes, and technology that are crucial for tumor suppression, diagnosis and treatment of human disease including cancer.