Epidemiologic Determinant of Cardiac Structure and Function Among Hispanics

描述(由申请人提供)：鉴于美国人口中拉美裔所占比例(&gt；16%)由拉美裔构成，以及对这一族群持续增长和老龄化的预期，拉美裔将成为美国医疗保健的重要消费者。拉美裔在某些亚群中携带更多的糖尿病、代谢综合征、高血压和西非血统，以及比非西班牙裔白人更低的社会经济条件，所有这些都可能影响心脏功能。相关文献很少，以前的研究受到样本量小、不能充分代表西班牙裔异质性以及过时或不全面的方法论的限制。对拉美裔成年人心脏收缩和舒张期功能异常的患病率没有基于人群的估计。我们的初步数据显示，与非西班牙裔白人相比，拉美裔美国人的心脏结构异常更多。因此，我们预计拉美裔成年人中心脏功能异常的发生率很高，但这一点还没有得到充分的研究。西班牙裔社区健康研究--拉丁裔研究(HCHS-SOL)是由美国国立卫生研究院资助的16,000名拉美裔成年人的队列，是实施一项研究以填补所述空白的独特且具有成本效益的机会。具体地说，我们建议建立一个独特的队列，名为ECHO-SOL(拉美裔/拉美裔超声心动图研究)。通过单独的现场访问，对来自HCHS-SOL的1800名拉美裔成年人进行超声心动图检查，以确定基于人群的拉美裔成年人心脏功能异常患病率的估计，拉美裔亚组之间心脏功能的异质性程度，并建立与拉美裔人群特别相关的决定因素(糖尿病生物标志物和心理社会/社会经济因素)与心脏结构和功能的关系。这项拟议的研究将首次提供专门针对美国拉美裔的最大和最全面的超声心动图参数数据集，并将首次揭示拉美裔亚群和心理社会/社会经济因素之间的异质性对拉美裔成年人心脏结构和功能的相对重要性。ECHO-SOL将在了解拉美裔心血管健康方面非常有前途，并与未来的公共卫生规划高度相关。

DESCRIPTION (provided by applicant): Given the proportion of the United States (US) population (>16%) composed of Hispanics and the anticipation for continued growth and aging of this ethnic group, Hispanics will comprise a significant consumer of US health care. Hispanics carry more diabetes, metabolic syndrome, hypertension, and West African ancestry in certain subgroups as well as lower socioeconomic conditions than non-Hispanic whites all of which likely affect cardiac function. Pertinent literature is scarce with prior studies being limited by small sample size, inadequate representation of Hispanic heterogeneity, and outdated or less than comprehensive methodology. There are no population-based estimates of the prevalence of abnormal systolic and diastolic cardiac function for Hispanic adults. Our preliminary data suggest that there is more abnormal cardiac structure among Hispanics compared to non-Hispanic whites. We would therefore expect a high prevalence of abnormal cardiac function among Hispanic adults, but this has been understudied. The Hispanic Community Health Study - Study of Latinos (HCHS-SOL), an NIH-funded cohort of 16,000 Hispanic adults, represents a unique, and cost-effective, opportunity to implement a study to fill the gaps described. Specifically, we propose to establish a unique cohort, named ECHO-SOL (Echocardiographic Study of Latinos/Hispanics). Using a separate site visit to obtain an echocardiographic examination of a subsample of 1,800 Hispanic adults from HCHS-SOL to determine a population-based estimate of the prevalence of abnormal systolic and diastolic cardiac function in Hispanic adults, the degree of heterogeneity between Hispanic subgroups in cardiac function, and to establish the relationship of determinants particularly relevant to the Hispanic population (diabetes biomarkers and psychosocial / socioeconomic factors) to cardiac structure and function. The proposed study will provide for the first time the largest and most comprehensive dataset of echocardiographic parameters focused solely on US Hispanics and will be the first to untangle the relative importance of the heterogeneity between Hispanic subgroups and psychosocial / socioeconomic factors on cardiac structure and function among Hispanic adults. ECHO-SOL will be extremely promising in learning about Hispanic cardiovascular health and highly relevant to future public health planning.