Epidemiologic Determinant of Cardiac Structure and Function Among Hispanics

描述（由申请人提供）：考虑到西班牙裔美国人占美国人口的比例（约16%），以及该种族群体持续增长和老龄化的预期，西班牙裔美国人将成为美国医疗保健的重要消费者。与非西班牙裔白人相比，西班牙裔在某些亚群中携带更多的糖尿病、代谢综合征、高血压和西非血统，以及较低的社会经济条件，所有这些都可能影响心脏功能。相关文献很少，先前的研究受到样本量小、西班牙裔异质性代表性不足以及过时或不全面的方法的限制。目前还没有针对西班牙裔成年人心脏收缩和舒张功能异常患病率的基于人群的估计。我们的初步数据表明，与非西班牙裔白人相比，西班牙裔白人有更多的心脏结构异常。因此，我们预计西班牙裔成年人中心功能异常的患病率很高，但这一点尚未得到充分研究。西班牙裔社区健康研究-拉丁裔研究（HCHS-SOL）是一项由美国国立卫生研究院资助的16,000名西班牙裔成年人的队列研究，它代表了一个独特的、具有成本效益的机会，可以实施一项研究来填补所描述的空白。具体来说，我们建议建立一个独特的队列，命名为ECHO-SOL（拉丁裔/西班牙裔超声心动图研究）。通过单独的现场访问，对来自HCHS-SOL的1800名西班牙裔成年人进行超声心动图检查，以确定西班牙裔成年人收缩期和舒张期异常心功能患病率的基于人群的估计，以及西班牙裔亚组心功能的异质性程度。并建立与西班牙裔人群特别相关的决定因素（糖尿病生物标志物和社会心理/社会经济因素）与心脏结构和功能的关系。拟议的研究将首次提供最大和最全面的超声心动图参数数据集，仅针对美国西班牙裔，并将首次解开西班牙裔亚群之间异质性的相对重要性，以及西班牙裔成年人心脏结构和功能的社会心理/社会经济因素。ECHO-SOL将非常有希望了解西班牙心血管健康，并与未来的公共卫生规划高度相关。

DESCRIPTION (provided by applicant): Given the proportion of the United States (US) population (>16%) composed of Hispanics and the anticipation for continued growth and aging of this ethnic group, Hispanics will comprise a significant consumer of US health care. Hispanics carry more diabetes, metabolic syndrome, hypertension, and West African ancestry in certain subgroups as well as lower socioeconomic conditions than non-Hispanic whites all of which likely affect cardiac function. Pertinent literature is scarce with prior studies being limited by small sample size, inadequate representation of Hispanic heterogeneity, and outdated or less than comprehensive methodology. There are no population-based estimates of the prevalence of abnormal systolic and diastolic cardiac function for Hispanic adults. Our preliminary data suggest that there is more abnormal cardiac structure among Hispanics compared to non-Hispanic whites. We would therefore expect a high prevalence of abnormal cardiac function among Hispanic adults, but this has been understudied. The Hispanic Community Health Study - Study of Latinos (HCHS-SOL), an NIH-funded cohort of 16,000 Hispanic adults, represents a unique, and cost-effective, opportunity to implement a study to fill the gaps described. Specifically, we propose to establish a unique cohort, named ECHO-SOL (Echocardiographic Study of Latinos/Hispanics). Using a separate site visit to obtain an echocardiographic examination of a subsample of 1,800 Hispanic adults from HCHS-SOL to determine a population-based estimate of the prevalence of abnormal systolic and diastolic cardiac function in Hispanic adults, the degree of heterogeneity between Hispanic subgroups in cardiac function, and to establish the relationship of determinants particularly relevant to the Hispanic population (diabetes biomarkers and psychosocial / socioeconomic factors) to cardiac structure and function. The proposed study will provide for the first time the largest and most comprehensive dataset of echocardiographic parameters focused solely on US Hispanics and will be the first to untangle the relative importance of the heterogeneity between Hispanic subgroups and psychosocial / socioeconomic factors on cardiac structure and function among Hispanic adults. ECHO-SOL will be extremely promising in learning about Hispanic cardiovascular health and highly relevant to future public health planning.