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Racial/Ethnic Disparities in Kidney Function Decline: Genes or Environment?

肾功能下降的种族/民族差异：基因还是环境？

基本信息

批准号：
8512713
负责人：
Carmen Alicia Peralta
金额：
$ 15.43万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2015-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8512713
关键词：
Address Admixture Adult Adverse event Affect African African American Atherosclerosis Award Blood Pressure Cardiovascular system Caucasians Caucasoid Race Characteristics Chinese American Chronic Kidney Failure Clinical Complex Creatinine Data Diabetes Mellitus Disease Progression Education End stage renal failure Environment Environmental Risk Factor Epidemic Epidemiologist Equation Ethnic Origin Ethnic group Food Foundations Functional disorder Future Genes Genetic Genetic Predisposition to Disease Genotype Glomerular Filtration Rate Goals Hispanics Incidence Income Individual Intervention Kidney Kidney Diseases Knowledge Lead Link Low Prevalence Low income Maps Measurement Measures Mentored Patient-Oriented Research Career Development Award Mentors Methods Minority National Heart, Lung, and Blood Institute Native Americans Neighborhoods Obesity Participant Pathway interactions Patient Self-Report Persons Physical environment Population Prevention strategy Psyche structure Race Relative (related person)Renal function Research Research Personnel Resources Risk Risk Factors Safety Sample Size Social Environment Socioeconomic Factors Socioeconomic Status Staging Subgroup Testing Time Visit Walking Work base career development cohesion cohort cost disorder risk gene environment interaction genetic epidemiology genome wide association study high risk improved novel novel marker post gamma-globulins programs racial and ethnic racial and ethnic disparities social social health determinants socioeconomics vascular inflammation

项目摘要

Project Summary: This is an application for a K23 award for Dr. Carmen A. Peralta, who proposes a novel, multi-disciplinary approach to understanding racial/ethcnic disparities in kidney function decline. This award will allow Dr. Peralta the resources and protected time to achieve the following career development goals: (1) to become an independent, translational clinical researcher in the field of racial/ethnic disparities in kidney disease; (2) to become an expert in the application of genetic epidemiology methods to study these differences; and (3) to utilize sociodemographic measurements to improve understanding of the complex mechanisms involved in these disparities. To achieve these goals, Dr. Peralta has assembled a mentoring team comprised of her sponsor and primary mentor, Dr. Michael Shlipak (an expert in the field of cardiovascular complications of early kidney dysfunction), and two co-mentors: Dr. Neil Risch (a genetic epidemiologist) and Dr. Paula Braveman (an expert in social determinants of health). The epidemic of kidney disease currently affects 13% of U.S. adults, and the progression to end stage renal disease (ESRD) affects minorities disparately. African-Americans and Hispanics are the fastest grow- ing groups in the ESRD population. Despite well-documented disparities in progression of advanced kidney disease to ESRD, no studies have evaluated the incidence of chronic kidney disease (CKD) or early kidney function decline in the US across racial/ethnic groups. It is unknown whether certain racial/ethnic groups have an increased genetic predisposition due to a common genetic ancestry or whether social or environ- mental factors explain observed differences. Using data from the Multi-Ethnic Study of Atherosclerosis (MESA), Dr. Peralta will compare rates of kidney function decline and incident CKD across four major racial groups and test possible genetic and sociodemographic mechanisms to explain these differences. Three specific aims are proposed: Aim 1: To compare rates of kidney function decline and incident chronic kidney disease across four major racial/ethnic groups (Caucasians, African-Americans, Hispanics, and Chinese- Americans) using creatinine and cystatin C based measures; Aim 2: To evaluate whether genetic ancestry is an independent predictor of kidney function decline and incident chronic kidney disease within racial groups and to explore gene-environment interactions in kidney function decline and incident kidney; and Aim 3: To evaluate the association of individual and neighborhood-level socioeconomic characteristics with kidney function decline and incident kidney disease across racial groups. Relevance: A better understanding of the mechanisms involved in racial/ethnic disparities in kidney function decline at earlier stages of kidney dysfunction could lead to important interventions and prevention strategies in halting this costly epidemic. .

项目概要：这是卡门博士K23奖的申请。佩拉尔塔提出了一部小说，多学科方法来理解肾功能下降的种族/民族差异。这个奖项将允许Peralta博士的资源和保护的时间来实现以下职业发展目标：（1）成为肾脏疾病种族/民族差异领域的独立、转化临床研究者疾病;（2）成为应用遗传流行病学方法研究这些疾病的专家差异;（3）利用社会人口测量，以提高对复杂的理解这些差异所涉及的机制。为了实现这些目标，佩拉尔塔博士组建了一个指导小组，团队由她的赞助商和主要导师Michael Shlipak博士（该领域的专家）组成。早期肾功能不全的心血管并发症），和两个共同导师：尼尔Risch博士（遗传流行病学家）和Paula Braveman博士（健康的社会决定因素专家）。肾脏疾病的流行目前影响着13%的美国成年人，并且进展到终末期肾脏疾病（ESRD）严重影响少数民族。非洲裔美国人和西班牙裔美国人是增长最快的- 在ESRD人群中。尽管有充分的证据表明晚期肾脏疾病的进展存在差异，虽然从慢性肾脏病（CKD）到终末期肾病（ESRD）的发病率很高，但尚无研究评估慢性肾脏病（CKD）或早期肾脏病（ESRD）的发病率。美国各种族/族裔群体的功能下降。目前尚不清楚某些种族/族裔群体是否由于共同的遗传祖先或社会或环境因素，心理因素解释了观察到的差异。使用来自多民族动脉粥样硬化研究的数据 Peralta博士将比较四个主要种族的肾功能下降率和CKD发病率。群体和测试可能的遗传和社会人口机制来解释这些差异。三目的1：比较肾功能下降和慢性肾功能衰竭的发生率，疾病在四个主要种族/民族群体（高加索人，非洲裔美国人，西班牙裔和中国人- 美国人）使用肌酸酐和半胱氨酸蛋白酶抑制剂C为基础的措施;目的2：评估遗传祖先是否是种族群体中肾功能下降和慢性肾脏疾病事件的独立预测因子目的3：探讨肾功能下降和肾脏病的基因-环境相互作用，评估个人和社区水平的社会经济特征与肾脏疾病的关系功能下降和肾脏疾病的发病率。相关性：更好地了解肾功能种族/民族差异的机制在肾功能不全的早期阶段下降可能导致重要的干预和预防策略阻止这一代价高昂的流行病。.