Developing a clinical cohort of histopathologically characterized lymphoma

开发具有组织病理学特征的淋巴瘤的临床队列

• 批准号: 8436855
• 负责人: Satish Gopal
• 金额: $ 14.02万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-20 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8436855
• 关键词: AIDS-Related Lymphoma; Africa South of the Sahara; African; Area; Basic Science; Biopsy; Biopsy Specimen; Biostatistical Methods; Cancer Burden; Caring; Cataloging; Catalogs; Classification; Classification Scheme; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Collection; Communicable Diseases; Conduct Clinical Trials; Core Biopsy; Correlative Study; Country; Data; Decision Making; Diagnosis; Diagnostic; Diagnostic Services; Disease; Enrollment; Epidemic; Fine needle aspiration biopsy; Flowers; Frequencies; Future; Goals; HIV; Health; Hematologic Neoplasms; Hematology; Hodgkin Disease; Hospital Referrals; Incidence; Individual; Infection; International; K-Series Research Career Programs; Laboratories; Lead; Learning; Life; Literature; Lymphatic Diseases; Lymphoma; Lymphomagenesis; Malawi; Malignant - descriptor; Malignant Neoplasms; Measures; Medical; Medical Oncologist; Mentored Research Scientist Development Award; Mentors; Methods; Minority; Molecular; Mutation; Non-Hodgkin' s Lymphoma; Non-Malignant; North Carolina; Pathologic; Pathology; Patients; Phase II Clinical Trials; Physicians; Quality-of-Life Assessment; Research; Research Design; Research Personnel; Resources; Secondary to; Specimen; Tanzania; Time; Tissues; Toxic effect; Treatment Cost; Tuberculosis; Universities; Viral; base; cancer therapy; chemotherapy; cohort; design; diagnostic accuracy; effective therapy; experience; follow-up; health related quality of life; improved; interest; international center; lymph nodes; multidisciplinary; oncology; prospective; response; routine care; skills; treatment strategy; tumorigenesis

DESCRIPTION (provided by applicant): This is an application for a Fogarty International Center K01 International Research Scientist Development Award for Dr. Satish Gopal, an infectious disease physician and medical oncologist at the University of North Carolina at Chapel Hill. Dr. Gopal is establishing himself as a young investigator in the areas of HIV-associated lymphoma and lymphoma treatment in resource-limited settings. This K01 award will provide Dr. Gopal with the support necessary to accomplish the following goals: (1) to become an expert in clinical trial conduct in resource-limited settings; (2) to develop skills in multidisciplinary, long-distance collaboration; (3) to gain additional experience in advanced study design and biostatistical methods; and (4) to learn fundamentals of health-related quality of life research. To achieve these goals, Dr. Gopal has assembled a mentoring team comprised of a US primary mentor, Dr. Thomas Shea, Interim Chief of the Division of Hematology and Oncology, an international leader in collaborative clinical trials in hematologic malignancies, and a Malawi primary mentor, Dr. Mina Hosseinipour, Clinical Director of UNC Project-Malawi and an expert in clinical trials in sub-Saharan Africa, as well as three co-mentors; Drs. Blossom Damania and Dirk Dittmer, experts in pathogenic mechanisms of viral oncogenesis with particular interest in HIV malignancies; and Dr. William Miller, an expert in analytic methods and mentoring young investigators toward research independence. Lymphoma is one of the most common cancers in sub-Saharan Africa with rapidly increasing incidence. Dr. Gopal's research will focus on accurate histopathologic diagnosis among patients with suspected lymphoma in Malawi (Aim 1), systematic collection of clinical and laboratory data among patients with suspected lymphoma (Aim 2), and longitudinal follow-up among those with confirmed hematologic malignancies receiving treatment under local conditions (Aim 3). In Aim 1, Dr. Gopal will perform core lymph node biopsies on at least 200 consecutively enrolled patients with suspected lymphoma. In Aim 2, Dr. Gopal will collect relevant clinical and laboratory data among patients at the time of enrollment and lymph node biopsy, and correlate these data with final histopathologic diagnosis. In Aim 3, Dr. Gopal will perform systematic, longitudinal assessments for 2 years among those with confirmed hematologic malignancies to evaluate response to therapy, treatment-related toxicities, costs of treatment, and health-related quality o life (HRQOL) measures. The studies outlined in this proposal will form the basis for a multicenter clinical trial of lymphoma treatment in sub-Saharan Africa to be proposed in an R01 application before the end of the career development award period. PUBLIC HEALTH RELEVANCE: The burden of lymphoma is rapidly increasing in sub-Saharan Africa, and current diagnostic and treatment strategies are inadequate. Improved understanding of the clinical and histopathologic features of lymphoma is critical to developing effective treatments which are feasible under local conditions in resource- limited settings.

描述（由申请人提供）：这是一份福格蒂国际中心K01国际研究科学家发展奖的申请，申请对象是北卡罗来纳大学教堂山分校的感染性疾病医生和医学肿瘤学家Satish Gopal博士。Gopal博士在艾滋病相关淋巴瘤和资源有限的淋巴瘤治疗领域建立了自己的年轻研究者地位。这项K01奖将为Gopal博士提供必要的支持，以实现以下目标：(1)在资源有限的环境中成为临床试验实施方面的专家；(2)培养多学科、远程协作的技能；(3)在高级研究设计和生物统计方法方面获得额外的经验；(4)学习健康相关生活质量研究的基础知识。为了实现这些目标，Gopal博士组建了一个指导团队，其中包括一位美国主要导师Thomas Shea博士，他是血液学和肿瘤学部门的临时主任，是血液学恶性肿瘤合作临床试验的国际领导者