Planning for a National Non-Communicable Disease Center of Research Excellence

项目摘要 本申请是对RFA-CA 15 -007的响应。它包括一个为期两年的规划期， 非传染性疾病（NCDs）卓越研究中心，专注于癌症，伤害和 心血管疾病（CVD）。这三个重点领域对公共卫生具有重大意义， 巨大的未满足的需求。我们的伙伴机构在这一申请中优先考虑这些项目： 医学院（COM）和卫生部（MOH）。根据RFA的意图， 北卡罗来纳州将作为申请的高收入国家伙伴机构，基于其 马拉维长达数十年的计划，与COM和MOH的长期合作历史，以及深入参与 癌症研究活动，特别是在马拉维。规划赠款将寻求参与我们和 在马拉维开展重大非传染性疾病项目的国际合作伙伴，如加州大学洛杉矶分校和贝勒医学院， 等人这是一个多个主要研究者的应用程序，具有高度互补的专业知识：Satish Gopal（CIMB/COM;癌症;临床研究）; Nyengo Mkandawire（COM;损伤;临床研究）; Mwapatsa Mipando（COM;心血管疾病;基础科学）; Dirk Dittmer（癌症;基础科学）。 此外，来自政府和其他支持研究项目的高级研究人员和领导将 在规划期间作为关键人员和顾问参与，利用了令人印象深刻的 马拉维国内外的教师。规划是开发一个中心将包括行政， 开发、临床、实验室、生物统计和实施核心，可作为资源 为该区域提供的培训，例如病理学和外科培训。在规划期间，将邀请合作伙伴 在现有资源和各机构活动的基础上，为每一项活动制定国家计划， 以及集体确定优先次序的新资源和活动。拟建中心的可持续性， 其影响将通过马拉维合作伙伴的强有力的自主权来确保，包括 最高级别的COM和MOH。我们寻求在马拉维境内建立合作伙伴的积极联系 马拉维以外的国际机构和研究网络将使该中心能够利用这些 对外关系，以实现在撒哈拉以南非洲地区的重要性。最后，通过催化广泛的 为了解决快速增长的非传染性疾病负担，该中心将为国家带来可衡量的好处， 马拉维人。

Project Summary Abstract This application is in response to RFA-CA15-007. It comprises a two-year planning period to develop a Malawi Center of Research Excellence for non-communicable diseases (NCDs), focused on cancer, injury, and cardiovascular disease (CVD). These three areas of concentration are of major public health importance with immense unmet need. They have been prioritized by our partner institutions in this application: the Malawi College of Medicine (COM) and Ministry of Health (MOH). Following the intent of the RFA the University of North Carolina (UNC) will serve as the high-income country partner institution for the application, based on its decades-long program in Malawi, long history of collaboration with COM and MOH, and deep involvement in cancer research activities specifically within Malawi. The planning grant will seek to engage US and International partners with significant NCD programs in Malawi, such as UCLA and Baylor College of Medicine, and others. This is a multiple principal investigators application with highly complementary expertise: Satish Gopal (UNC/COM; cancer; clinical investigation); Nyengo Mkandawire (COM; injury; clinical investigation); Mwapatsa Mipando (COM; cardiovascular disease; basic science); Dirk Dittmer (UNC; cancer; basic science). In addition, senior investigators and leadership from government and other supported research programs will participate as key personnel and consultants during the planning period, which leverages an impressive pool of faculty within and outside Malawi. The planning is to develop a center will include administrative, developmental, clinical, laboratory, biostatistics, and implementation cores and which may serve as a resource for the region, e.g. in pathology and surgery training. Partners will be invited during the planning period to contribute to a national plan for each of these, based on existing resources and activities across institutions, as well as new resources and activities that are collectively prioritized. Sustainability of the proposed center and its impact will be ensured by strong ownership from collaborating Malawian partners, including support by the highest levels of COM and MOH. We seek to establish active linkages of collaborating partners within Malawi to international institutions and research networks outside Malawi will allow the center to leverage these external relationships to achieve regional importance in sub-Saharan Africa. Finally, by catalyzing a broad national movement to address a rapidly growing NCD burden, the center will deliver measurable benefits to the people of Malawi.