Planning for a National Non-Communicable Disease Center of Research Excellence

项目摘要摘要 此应用程序响应RFA-CA15-007。它包括一个为期两年的规划期，以发展一个马拉维 非传染性疾病(NCDs)卓越研究中心，专注于癌症、伤害和 心血管疾病(CVD)。这三个集中区域对公共卫生具有重大意义 巨大的未得到满足的需求。在这项申请中，我们的伙伴机构已将它们列为优先事项：马拉维 医学院(COM)和卫生部(MOH)。遵循RFA的意图，哥伦比亚大学 北卡罗来纳州(北卡罗来纳州)将作为申请的高收入国家合作伙伴机构，基于其 在马拉维有数十年的项目，与COM和MOH合作的悠久历史，并深入参与 特别是在马拉维开展的癌症研究活动。规划拨款将寻求与美国和 在马拉维有重大非传染性疾病项目的国际合作伙伴，如加州大学洛杉矶分校和贝勒医学院， 还有其他人。这是一个具有高度互补性的专业知识的多个主要调查员应用程序： Gopal(UNC/COM；癌症；临床调查)；Nyengo Mkandawire(COM；损伤；临床调查)； Mwapatsa Mipando(COM；心血管疾病；基础科学)；Dirk Dittmer(北卡罗来纳大学；癌症；基础科学)。 此外，来自政府和其他支持的研究项目的高级调查人员和领导层将 在规划期间作为关键人员和顾问参与，这利用了令人印象深刻的 马拉维国内外的教职员工。规划是要发展一个中心，将包括行政， 开发、临床、实验室、生物统计和实施核心，可作为资源 在该地区，例如在病理学和外科培训方面。在规划期间，将邀请合作伙伴 在各机构现有资源和活动的基础上，为其中每一项的国家计划作出贡献，如 以及集体优先考虑的新资源和活动。拟建中心的可持续性和 其影响将通过马拉维合作伙伴的强大所有权来确保，包括由 最高水平的COM和MOH。我们寻求在马拉维境内建立合作伙伴之间的积极联系。 马拉维以外的国际机构和研究网络将使该中心能够利用这些 建立对外关系，以实现在撒哈拉以南非洲的区域重要性。最后，通过催化广泛的 解决快速增长的非传染性疾病负担的全国性运动，该中心将为 马拉维人民。

Project Summary Abstract This application is in response to RFA-CA15-007. It comprises a two-year planning period to develop a Malawi Center of Research Excellence for non-communicable diseases (NCDs), focused on cancer, injury, and cardiovascular disease (CVD). These three areas of concentration are of major public health importance with immense unmet need. They have been prioritized by our partner institutions in this application: the Malawi College of Medicine (COM) and Ministry of Health (MOH). Following the intent of the RFA the University of North Carolina (UNC) will serve as the high-income country partner institution for the application, based on its decades-long program in Malawi, long history of collaboration with COM and MOH, and deep involvement in cancer research activities specifically within Malawi. The planning grant will seek to engage US and International partners with significant NCD programs in Malawi, such as UCLA and Baylor College of Medicine, and others. This is a multiple principal investigators application with highly complementary expertise: Satish Gopal (UNC/COM; cancer; clinical investigation); Nyengo Mkandawire (COM; injury; clinical investigation); Mwapatsa Mipando (COM; cardiovascular disease; basic science); Dirk Dittmer (UNC; cancer; basic science). In addition, senior investigators and leadership from government and other supported research programs will participate as key personnel and consultants during the planning period, which leverages an impressive pool of faculty within and outside Malawi. The planning is to develop a center will include administrative, developmental, clinical, laboratory, biostatistics, and implementation cores and which may serve as a resource for the region, e.g. in pathology and surgery training. Partners will be invited during the planning period to contribute to a national plan for each of these, based on existing resources and activities across institutions, as well as new resources and activities that are collectively prioritized. Sustainability of the proposed center and its impact will be ensured by strong ownership from collaborating Malawian partners, including support by the highest levels of COM and MOH. We seek to establish active linkages of collaborating partners within Malawi to international institutions and research networks outside Malawi will allow the center to leverage these external relationships to achieve regional importance in sub-Saharan Africa. Finally, by catalyzing a broad national movement to address a rapidly growing NCD burden, the center will deliver measurable benefits to the people of Malawi.