Successful Cogn. Aging and Cardiovascular Risk Factors in the Central Valley CR

成功的科恩。

• 批准号: 8211241
• 负责人: Jeremy M. Silverman
• 金额: $ 13.89万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-01 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8211241
• 关键词: Affect; Age; Age-Years; Aging; Aging-Related Process; Alzheimer' s Disease; Attenuated; C-reactive protein; Cardiovascular system; Cholesterol; Cognition; Cognitive aging; Collaborations; Costa Rica; Costa Rican; Country; Data; Dementia; Diabetes Mellitus; Elderly; Epigenetic Process; Family; Family member; Genes; Genetic; Genetic Heterogeneity; Heritability; Heterogeneity; Hypertension; Impaired cognition; Institution; Intervention; Lead; Life; Life Expectancy; Link; Longevity; Maintenance; Memory; Modeling; Paper; Pattern; Phenotype; Pilot Projects; Population; Public Health; Puerto Rico; Relative (related person); Research; Research Infrastructure; Research Personnel; Research Proposals; Risk; Risk Factors; Role; Sampling; Site; Subgroup; Survivors; Training; Universities; Validation; Writing; base; cardiovascular risk factor; cognitive function; cohort; design; experience; innovation; investigator training; medical schools; mortality; neuropsychological; prevent; proband; trait

DESCRIPTION (provided by applicant): For samples primarily under 75 years of age, some cardiovascular risk factors (CVRFs) have been associated with increased risk of cognitive decline, dementia, and Alzheimer's disease. Although frequently interpreted as applying generally to all elderly, findings from our group and others suggest that such associations are greatly diminished or even reversed in more elderly samples. If, as these results suggest, the effects of some CVRFs do not reflect stable cardiovascular risk across the life span, these effects may reflect enduring traits possessed by some protected survivors. Alternatively, they may reflect adaptive changes in some elderly as they progress to late old ages while maintaining good cognition. Aim 1 of this R21 will determine the applicability of each of these three models of successful cognitive aging (SCA; living at least 90 years free of cognitive impairment) to the relationships of cardiovascular risk factors (CVRFs) with neuropsychological phenotypes. We will examine the effects of CVRFs on neuropsychological phenotypes by comparing proband and relative groups highlighted by the respective SCA model. The project will be performed in Costa Rica, which has high life expectancy and reduced genetic and cultural heterogeneity. In Aim 2, the Aim 1 results will be used to design a multi-site R01 on the genetic and epigenetic basis of SCA, concentrating on genes affecting CVRFs associated with each model. Aim 3 is to build research capacity in Costa Rica upon an already existing infrastructure. We will train the experienced and dedicated Costa Rican investigators on this research team, so they can perform independent studies of SCA and aging in Costa Rica based on data from this R21, the R01, and other collaborations. PUBLIC HEALTH RELEVANCE: The effects of some risk factors for cognitive decline - a major public health problem as the population ages - are greatly diminished or even reversed in relatively older samples. This project will distinguish among competing models for successful cognitive aging (SCA) despite the presence of risk factors. A major study of the genetic and epigenetic basis of SCA will be designed based on these results, to identify mechanisms underlying SCA, leading to interventions to promote it.

描述（由申请方提供）：对于主要在75岁以下的样本，一些心血管风险因素（CVRF）与认知能力下降、痴呆和阿尔茨海默病的风险增加相关。尽管经常被解释为普遍适用于所有老年人，但我们小组和其他人的研究结果表明，这种联系在更多老年人样本中大大减少，甚至逆转。如这些结果所示，如果某些CVRF的影响不能反映整个生命周期内稳定的心血管风险，则这些影响可能反映了某些受保护的幸存者所具有的持久特征。或者，它们可能反映了一些老年人的适应性变化，因为他们在保持良好认知的同时进入晚年。本R21的目的1将确定这三种成功认知老化模型（SCA;至少90年无认知障碍）中每一种模型对心血管危险因素（CVRF）与神经心理表型关系的适用性。我们将通过比较先证者和相应SCA模型突出显示的亲属组来检查CVRF对神经心理表型的影响。该项目将在哥斯达黎加进行，该国预期寿命高，遗传和文化异质性较低。在目标2中，目标1的结果将用于在SCA的遗传和表观遗传基础上设计多位点R 01，集中于影响与每个模型相关的CVRF的基因。目标3是在现有基础设施的基础上建设哥斯达黎加的研究能力。我们将在这个研究团队中培训经验丰富、敬业的哥斯达黎加研究人员，以便他们能够根据R21、R 01和其他合作项目的数据，在哥斯达黎加进行SCA和衰老的独立研究。 公共卫生关系：随着人口老龄化，认知能力下降是一个主要的公共卫生问题，一些风险因素对认知能力下降的影响在相对较老的样本中大大减少，甚至逆转。该项目将区分成功认知老化（SCA）的竞争模型，尽管存在风险因素。一个主要的研究SCA的遗传和表观遗传基础将设计基于这些结果，以确定SCA的潜在机制，导致干预措施，以促进它。