Molecular Epidemiology and Key Issues of Foodborne Pathogens in Eastern Africa

描述（由申请人提供）：我们提议建立一个由俄亥俄州立大学健康科学中心和东非高等院校共享的国际研究培训计划。该项目的长期目标是在东非学术机构（埃塞俄比亚亚的斯亚贝巴大学、肯尼亚内罗毕大学和坦桑尼亚索科因大学）建立可持续的食源性病原体研究和培训能力。食源性和水传播疾病，如侵袭性沙门氏菌病、动物传播结核病、病毒性食物/水传播病原体和产生志贺氏毒素的大肠杆菌等，是撒哈拉以南非洲发病率和死亡率很高的主要公共卫生问题。然而，该地区的科研培训能力极其薄弱。该计划将以食源性病原体研究，特别是沙门氏菌病和抗菌素耐药性方面现有的试点合作研究工作为基础，并以俄勒冈州立大学和所有伙伴研究所最近在东非举办的区域联盟和研讨会为基础。该计划的具体任务是利用分子流行病学、免疫学和疾病建模等多学科方法培训未来的培训师（研究所非博士学位教师和实验室支持人员）。最终目标是培养一批能够有效开展食源性病原体预防和控制研究和培训的科学家。本研究培训计划将采用活体轨道进行：轨道1是一个三明治格式的博士前培训，有4名博士和2名硕士。受训者将有机会在俄勒冈州立大学获得大量的机会，利用资金充足的研究领域，包括轮状病毒、沙门氏菌病、结核病和大肠杆菌0157:H7。第二阶段将包括针对实验室技术人员的短期培训，并将在一个著名的中央培训和实验室机构：埃塞俄比亚和肯尼亚的国际畜牧研究所（ILRI）进行。这项研究培训计划还将在三个东非国家的科学家之间引入一种区域内合作的文化，以及兽医、医生和环境卫生科学家等利益攸关方之间的跨学科合作，以有效解决主要的食源性病原体问题。

DESCRIPTION (provided by applicant): We propose to establish an international Research Training Program shared between The Ohio State University Health Sciences Center and Institutes of Higher Learning in East Africa. The long-term goal of this program is to establish sustainable research and training capacity for foodborne pathogen research and training in eastern African academic institutes (Addis Ababa University, Ethiopia; University of Nairobi, Kenya and Sokoine University, Tanzania). Foodborne and waterborne diseases such as invasive salmonellosis, animal-borne tuberculosis, viral food/waterborne pathogenand Shiga-toxin producing E. coli are major public health issues with a high morbidity and mortality in Sub-Saharan Africa. However, the research training capacities in the region are extremely weak. This program will build on existing pilot collaborative research efforts in foodborne pathogen research, particularly salmonellosis and antimicrobial resistance and based on a regional consoritum and workshop recently conducted in Eastern Africa with OSU and all partner institutes. The specific mission of this program is to train the future trainers (non-PhD holding faculty members at the institutes and laboratory support staff) using multi-disciplinary approaches such as molecular epidemiology, immunology and disease modeling. The ultimate goal is to develop a critical mass of scientists capable of effectively conducting research and training on foodborne pathogens towards prevention and control. This research training program will be conducted using vivo Tracks: Track 1 is a sandwich format pre-doctoral training for 4 PhD and 2 MSc. Trainees will have access to multitudes of opportunities at OSU leveraged with well-funded research areas including rotavirus, salmonellosis, tuberculosis and E. coli 0157:H7. Track 2 will involve a short-term training that will target laboratory technologists and will be conducted at a reputable central training and laboratory facility: Int'l Livestock Research Institute (ILRI) in Ethiopia and Kenya. This research training program also will introduce a culture of intra-regional collaboration among scientists within the three eastern African countries as well as inter-disciplinary collaboration among stakeholders including veterinarians, physicians and environmental health scientists to effectively address major foodborne pathogen issues. PUBLIC HEALTH RELEVANCE: Foodborne pathogens are major public health concerns worldwide. Currently, more than 75% of newly emerging infectious diseases is known to be zoonotic and many are foodborne in nature. This research training program will target three countries in east Africa to develop their research and training capacity in this very important area.