Sustainable One Health Research Training Capacity: Molecular Epidemiology of Zoonotic Foodborne and Waterborne Pathogens in Eastern Africa

可持续单一健康研究培训能力：东非人畜共患食源性和水源性病原体的分子流行病学

• 批准号: 9670185
• 负责人: WONDWOSSEN A. GEBREYES
• 金额: $ 25.68万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9670185
• 关键词: Address; Africa; Africa South of the Sahara; African; Animals; Antimicrobial Resistance; Area; Collaborations; Development; Diagnostic; Discipline; Disease; Doctor of Philosophy; Eastern Africa; Environmental Health; Ethiopia; Food; Future; Genomics; Goals; Health; Infectious Diseases Research; Institutes; International; Kenya; Laboratories; Leadership; Learning; Leishmaniasis; Measures; Mission; Molecular Epidemiology; Morbidity - disease rate; Ohio; Physicians; Prevention; Public Health; Research; Research Personnel; Research Training; Rotavirus; Salmonella infections; Scientist; System; Tanzania; Training; Training Programs; Tuberculosis; Universities; Vector-transmitted infectious disease; Veterinarians; Viral; Zoonoses; digital; foodborne; foodborne pathogen; implementation science; mortality; multidisciplinary; pre-doctoral; programs; success; waterborne; waterborne pathogen

We propose to strengthen and sustain our international Research Training Program shared between The Ohio State University and Institutes of Higher Learning in East Africa. Expanding the successes in the first cycle, the long-term goal of this program is to establish sustainable research and training capacity for zoonotic infectious diseases research in eastern Africa. The specific mission of the proposed program is to train the future researchers and trainers using an integrated multi-disciplinary "One Health" approach. The ultimate goal is to establish sustainable critical mass of capable scientists that can effectively conduct research on zoonotic diseases and implement prevention and control systems. The main targets of the proposed program are four eastern African academic institutes (University of Gondar and Addis Ababa University, Ethiopia; University of Nairobi, Kenya and Sokoine University, Tanzania). Food-, water-, and vector-borne infectious diseases such as invasive salmonellosis, animal-borne tuberculosis, viral food/waterborne pathogen and vector-borne diseases are major global public health concerns with a high morbidity and mortality in sub-Saharan Africa. However, the research training capacities in the region remain extremely weak. In the current cycle, we made key transformations to increase the success of our program including: 1) revamped priorities including water-borne and vector-borne diseases such; 2) refined discipline areas are now more targeted and measureable such as rapid diagnostic development, antimicrobial resistance and genomics; 3) integrated electronic and digital approaches for research and training to maximize the impact of our program and 4) emphasized scientific leadership and implementation science, to maximize impact and sustain results. This research training program will be conducted using two Tracks: Track 1 is a sandwich format pre­-doctoral training for PhD and MSc. Trainees will have ample opportunities at OSU leveraged with research areas including rotavirus, salmonellosis, tuberculosis and Leishmaniasis. Track 2 will involve a short-term training that will target laboratory technologists. This research training program also will strengthen intra-regional collaboration among scientists including veterinarians, physicians and environmental health scientists to effectively address zoonotic diseases.

我们建议加强和维持俄亥俄州立大学和东非高等学院之间共享的国际研究培训计划。扩大第一个周期的成果，该方案的长期目标是建立东非人畜共患传染病研究的可持续研究和培训能力。拟议方案的具体任务是使用综合多学科的“同一健康”方法培训未来的研究人员和培训者。最终目标是建立可持续的有能力的科学家临界群体，能够有效地开展人畜共患疾病研究并实施预防和控制系统。拟议方案的主要目标是四个东非学术机构(贡达尔大学和亚的斯亚贝巴大学、埃塞俄比亚内罗毕;大学和坦桑尼亚索科内大学)。食品、水和媒介传播的传染病，如侵袭性沙门氏菌病、动物传播的结核病、病毒性食物/水传播病原体和媒介传播疾病，是全球主要的公共卫生问题，撒哈拉以南非洲的发病率和死亡率都很高。然而，该区域的研究培训能力仍然非常薄弱。在当前的周期中，我们进行了关键的转变，以增加我们计划的成功，包括：1)调整了优先事项，包括水传播和媒介传播的疾病；2)改进的学科领域现在更有针对性和可测性，如快速诊断开发、抗菌素耐药性和基因组学；3)研究和培训的电子和数字集成方法，以最大限度地提高我们计划的影响；4)强调科学领导和实施科学，以最大限度地发挥影响和维持成果。该研究培训计划将使用两个轨道进行：第一轨道是针对博士和硕士的三明治形式的博士前培训。学员将有大量机会在俄亥俄州立大学从事轮状病毒、沙门氏菌病、结核病和利什曼病等研究领域的研究。第二条轨道将包括针对实验室技术人员的短期培训。这项研究培训计划还将加强包括兽医、医生和环境卫生科学家在内的科学家之间的区域内合作，以有效地应对人畜共患疾病。