Sustainable One Health Research Training Capacity: Molecular Epidemiology of Zoonotic Foodborne and Waterborne Pathogens in Eastern Africa

可持续单一健康研究培训能力：东非人畜共患食源性和水源性病原体的分子流行病学

• 批准号: 10359840
• 负责人: WONDWOSSEN A. GEBREYES
• 金额: $ 25.81万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10359840
• 关键词: Address; Africa; Africa South of the Sahara; African; Animals; Antimicrobial Resistance; Area; Collaborations; Development; Discipline; Disease; Doctor of Philosophy; Eastern Africa; Environmental Health; Ethiopia; Food; Future; Genomics; Goals; Health; Infectious Diseases Research; Institutes; International; Kenya; Laboratories; Leadership; Learning; Leishmaniasis; Measures; Mission; Molecular Epidemiology; Morbidity - disease rate; Ohio; Physicians; Prevention; Public Health; Rapid diagnostics; Research; Research Personnel; Research Training; Rotavirus; Salmonella infections; Scientist; System; Tanzania; Training; Training Programs; Tuberculosis; Universities; Vector-transmitted infectious disease; Veterinarians; Viral; Zoonoses; digital; foodborne; foodborne pathogen; implementation science; mortality; multidisciplinary; pre-doctoral; programs; success; waterborne; waterborne pathogen

We propose to strengthen and sustain our international Research Training Program shared between The Ohio State University and Institutes of Higher Learning in East Africa. Expanding the successes in the first cycle, the long-term goal of this program is to establish sustainable research and training capacity for zoonotic infectious diseases research in eastern Africa. The specific mission of the proposed program is to train the future researchers and trainers using an integrated multi-disciplinary "One Health" approach. The ultimate goal is to establish sustainable critical mass of capable scientists that can effectively conduct research on zoonotic diseases and implement prevention and control systems. The main targets of the proposed program are four eastern African academic institutes (University of Gondar and Addis Ababa University, Ethiopia; University of Nairobi, Kenya and Sokoine University, Tanzania). Food-, water-, and vector-borne infectious diseases such as invasive salmonellosis, animal-borne tuberculosis, viral food/waterborne pathogen and vector-borne diseases are major global public health concerns with a high morbidity and mortality in sub-Saharan Africa. However, the research training capacities in the region remain extremely weak. In the current cycle, we made key transformations to increase the success of our program including: 1) revamped priorities including water-borne and vector-borne diseases such; 2) refined discipline areas are now more targeted and measureable such as rapid diagnostic development, antimicrobial resistance and genomics; 3) integrated electronic and digital approaches for research and training to maximize the impact of our program and 4) emphasized scientific leadership and implementation science, to maximize impact and sustain results. This research training program will be conducted using two Tracks: Track 1 is a sandwich format pre­-doctoral training for PhD and MSc. Trainees will have ample opportunities at OSU leveraged with research areas including rotavirus, salmonellosis, tuberculosis and Leishmaniasis. Track 2 will involve a short-term training that will target laboratory technologists. This research training program also will strengthen intra-regional collaboration among scientists including veterinarians, physicians and environmental health scientists to effectively address zoonotic diseases.

我们建议加强和维持俄亥俄州州立大学和东非高等院校之间共享的国际研究培训计划。该计划的长期目标是扩大第一周期的成功，为东非人畜共患传染病研究建立可持续的研究和培训能力。拟议方案的具体使命是采用综合多学科“同一健康”方法培训未来的研究人员和培训人员。最终目标是建立可持续的足够数量的有能力的科学家，他们能够有效地进行人畜共患病研究，并实施预防和控制系统。拟议方案的主要对象是东非的四个学术机构（贡达大学和阿迪斯大学、埃塞俄比亚内罗毕大学、肯尼亚内罗毕大学和坦桑尼亚索科因大学）。食源性、水源性和病媒传播的传染病，如侵袭性沙门氏菌病、动物传播的结核病、病毒性食源性/水源性病原体和病媒传播的疾病，是全球主要的公共卫生问题，在撒哈拉以南非洲地区发病率和死亡率很高。然而，该区域的研究培训能力仍然极为薄弱。在当前周期，我们进行了关键转型，以提高我们计划的成功率，包括：1）重新调整优先事项，包括水传播和媒介传播疾病，如; 2）细化学科领域现在更具针对性和可衡量性，如快速诊断开发，抗菌素耐药性和基因组学; 3）研究和培训的综合电子和数字方法，以最大限度地发挥我们计划的影响; 4）强调科学领导和实施科学，以最大限度地发挥影响并维持成果。这项研究培训计划将使用两个轨道进行：轨道1是一个三明治格式的博士和硕士学位前的博士培训。学员将有充足的机会在俄勒冈州立大学利用研究领域，包括轮状病毒，沙门氏菌病，结核病和利什曼病。轨道2将涉及针对实验室技术人员的短期培训。该研究培训计划还将加强包括兽医、医生和环境卫生科学家在内的科学家之间的区域内合作，以有效应对人畜共患病。

项目成果

Development and validation of questionnaire to assess exposure of children to enteric infections in the rural northwest Ethiopia.

• DOI: 10.1038/s41598-022-10811-x
• 发表时间: 2022-04-25
• 期刊: SCIENTIFIC REPORTS
• 影响因子: 4.6
• 作者: Gizaw, Zemichael;Yalew, Alemayehu Worku;Bitew, Bikes Destaw;Lee, Jiyoung;Bisesi, Michael
• 通讯作者: Bisesi, Michael

Fecal biomarkers of environmental enteric dysfunction and associated factors among children aged 24-59 months in east Dembiya district, northwest Ethiopia.

• DOI: 10.1186/s12876-022-02255-4
• 发表时间: 2022-04-08
• 期刊: BMC gastroenterology
• 影响因子: 2.4
• 作者: Gizaw Z;Yalew AW;Bitew BD;Lee J;Bisesi M
• 通讯作者: Bisesi M

Stunting among children aged 24-59 months and associations with sanitation, enteric infections, and environmental enteric dysfunction in rural northwest Ethiopia.

• DOI: 10.1038/s41598-022-23981-5
• 发表时间: 2022-11-11
• 期刊: Scientific reports
• 影响因子: 4.6

Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry.

• DOI: 10.1007/s42770-021-00635-8
• 发表时间: 2022-03
• 期刊: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
• 作者: de Mesquita Souza Saraiva M;Lim K;do Monte DFM;Givisiez PEN;Alves LBR;de Freitas Neto OC;Kariuki S;Júnior AB;de Oliveira CJB;Gebreyes WA
• 通讯作者: Gebreyes WA

Molecular detection and genetic characterization of kobuviruses and astroviruses in asymptomatic local pigs in East Africa.

• DOI: 10.1007/s00705-013-1942-x
• 发表时间: 2014-06
• 期刊: ARCHIVES OF VIROLOGY
• 影响因子: 2.7
• 作者: Amimo, Joshua O.;Okoth, Edward;Junga, Joseph O.;Ogara, William O.;Njahira, Moses N.;Wang, Qiuhong;Vlasova, Anastasia N.;Saif, Linda J.;Djikeng, Appolinaire
• 通讯作者: Djikeng, Appolinaire