Sustainable One Health Research Training Capacity: Molecular Epidemiology of Zoonotic Foodborne and Waterborne Pathogens in Eastern Africa

我们建议加强和维持俄亥俄州立大学和东非高等院校共享的国际研究培训项目。扩大第一个周期的成功，该方案的长期目标是在东非建立可持续的人畜共患传染病研究和培训能力。该计划的具体任务是使用综合多学科“同一个健康”方法培训未来的研究人员和培训人员。最终目标是建立可持续的临界数量的有能力的科学家，能够有效地开展人畜共患疾病的研究并实施预防和控制系统。拟议方案的主要目标是四所东非学术机构（埃塞俄比亚的贡达尔大学和亚的斯亚贝巴大学；肯尼亚的内罗毕大学和坦桑尼亚的索科因大学）。食物、水和媒介传播的传染病，如侵袭性沙门氏菌病、动物传播结核病、病毒性食物/水传播病原体和媒介传播疾病，是全球主要的公共卫生问题，在撒哈拉以南非洲发病率和死亡率很高。然而，该区域的研究培训能力仍然非常薄弱。在当前周期中，我们进行了关键变革，以增加我们方案的成功，包括：1)调整优先事项，包括水媒和媒介传播疾病；2)精细化的学科领域现在更具针对性和可测量性，如快速诊断发展、抗微生物药物耐药性和基因组学；3)整合电子和数字方法进行研究和培训，以最大限度地发挥我们项目的影响；4)强调科学领导和实施科学，以最大限度地发挥影响并维持结果。该研究培训计划将采用两个轨道进行：轨道一是三明治格式的博士和硕士博士前培训。学员将有充足的机会在俄勒冈州立大学利用研究领域，包括轮状病毒，沙门氏菌病，结核病和利什曼病。第二部分将包括针对实验室技术人员的短期培训。这项研究培训计划还将加强包括兽医、医生和环境卫生科学家在内的科学家之间的区域内合作，以有效解决人畜共患疾病。

We propose to strengthen and sustain our international Research Training Program shared between The Ohio State University and Institutes of Higher Learning in East Africa. Expanding the successes in the first cycle, the long-term goal of this program is to establish sustainable research and training capacity for zoonotic infectious diseases research in eastern Africa. The specific mission of the proposed program is to train the future researchers and trainers using an integrated multi-disciplinary "One Health" approach. The ultimate goal is to establish sustainable critical mass of capable scientists that can effectively conduct research on zoonotic diseases and implement prevention and control systems. The main targets of the proposed program are four eastern African academic institutes (University of Gondar and Addis Ababa University, Ethiopia; University of Nairobi, Kenya and Sokoine University, Tanzania). Food-, water-, and vector-borne infectious diseases such as invasive salmonellosis, animal-borne tuberculosis, viral food/waterborne pathogen and vector-borne diseases are major global public health concerns with a high morbidity and mortality in sub-Saharan Africa. However, the research training capacities in the region remain extremely weak. In the current cycle, we made key transformations to increase the success of our program including: 1) revamped priorities including water-borne and vector-borne diseases such; 2) refined discipline areas are now more targeted and measureable such as rapid diagnostic development, antimicrobial resistance and genomics; 3) integrated electronic and digital approaches for research and training to maximize the impact of our program and 4) emphasized scientific leadership and implementation science, to maximize impact and sustain results. This research training program will be conducted using two Tracks: Track 1 is a sandwich format pre­-doctoral training for PhD and MSc. Trainees will have ample opportunities at OSU leveraged with research areas including rotavirus, salmonellosis, tuberculosis and Leishmaniasis. Track 2 will involve a short-term training that will target laboratory technologists. This research training program also will strengthen intra-regional collaboration among scientists including veterinarians, physicians and environmental health scientists to effectively address zoonotic diseases.