EFECAB: Improving pig management to prevent epilepsy in Burkina Faso

EFECAB:改善布基纳法索的生猪管理以预防癫痫

基本信息

项目摘要

DESCRIPTION (provided by applicant): This proposal seeks support for a new initiative which extends the work of our pilot project, "Epidemiology and Burden of Neurocysticercosis in Bukina Faso" (R21 NS055353). Despite the fact that Burkina Faso is the second least developed country in the world, a strong research collaboration and dedication to improving the living conditions of the Burkinabi people made our pilot project, IFICAB ("Ivaluation du Fardeau Iconomique de la Cysticercose Au Burkina"), a success. The ultimate goal of the proposed project is to develop a sustainable, cost-beneficial and cost-effective intervention strategy to reduce the incidence and prevalence of neurocysticercosis (NCC) and associated neurological conditions across the lifespan. This proposal seeks to further strengthen research capacity through establishing reference centers for the immuno- diagnosis of cysticercosis in humans and pigs at the Institut de Recherche en Sciences de la Santi (IRSS) and for the radiological diagnosis of NCC at the Universiti de Ouagadougou. This will be done in conjunction with the creation of the Cysticercosis Working Group for Western and Central Africa, under the leadership of collaborators in Burkina Faso. Training two PhD students in neuroepidemiology and immunodiagnosis of cysticercosis and one masters student in public health is also proposed. Inclusion of epilepsy and NCC in the list of notifiable diseases for Burkina Faso will be pilot tested as a surveillance mechanism. Preliminary results indicate a high prevalence of epilepsy, NCC and cysticercosis in the three pilot villages studied. Based on these findings, we estimate that an educational intervention targeting pig farmers could reduce the incidence of infection in humans and pigs by one-half. We also estimate that this could result, in the long term, in reducing the incidence rate of recurrent seizures in Burkina Faso by 25% in villages where pigs are raised. We will use the PRECEDE PROCEED approach to develop educational materials to guide farmers in maximizing the monetary benefits of healthy pig raising. A pre-post randomized community trial will be conducted in 60 villages located in three provinces, using a 12-month baseline and 24 month post-intervention follow-up of 80 participants per village. The effectiveness of the educational materials in reducing the incidence rate of human and porcine cysticercosis, and of recurrent seizures and severe headaches as a secondary outcome, will be estimated. If effective, this sustainable intervention could be exported to other pig-raising countries in Sub- Saharan Africa to reduce the frequency of cysticercosis and epilepsy. PUBLIC HEALTH RELEVANCE: Neurocysticercosis is a disease caused by a tapeworm transmitted between humans and pigs that is responsible for many cases of epilepsy in countries where pigs are raised in poor sanitary conditions. This study proposes an intervention in Burkina Faso to reduce the prevalence this infection. If successful, the frequency of epilepsy will decline, greatly improving the life and health of these communities.
描述(由申请人提供):本提案寻求对一项新倡议的支持,该倡议扩展了我们的试点项目“布基纳法索脑囊虫病的流行病学和负担”(R21 NS 055353)的工作。尽管布基纳法索是世界上第二个最不发达国家,但强有力的研究合作和致力于改善布基纳法索人民的生活条件使我们的试点项目-“布基纳法索囊尾蚴Au Iconomique Au评估”-取得了成功。该拟议项目的最终目标是制定一种可持续的、具有成本效益和成本效益的干预策略,以减少整个生命周期内神经囊虫病(NCC)和相关神经系统疾病的发生率和患病率。该提案旨在进一步加强研究能力,办法是在卫生科学研究所建立人和猪囊虫病免疫诊断参考中心,在瓦加杜古大学建立NCC放射诊断参考中心。这项工作将与设立西非和中非囊虫病工作组同时进行,工作组由布基纳法索的合作者领导。还建议培养两名神经流行病学和囊虫病免疫诊断博士生和一名公共卫生硕士生。将把癫痫和非传染性疾病列入布基纳法索应报告的疾病清单,作为一种监测机制进行试点测试。初步结果表明,在所研究的三个试点村庄,癫痫、非传染性感冒和囊虫病的发病率很高。根据这些发现,我们估计,针对养猪户的教育干预可以将人类和猪的感染率降低一半。我们还估计,从长远来看,这可能会使布基纳法索养猪村庄的复发性癫痫发病率降低25%。我们将采用PRECEDE PROCEED方法开发教育材料,指导农民最大限度地提高健康养猪的经济效益。将在三个省的60个村庄进行一项前后随机社区试验,采用12个月基线和24个月干预后随访,每个村庄有80名参与者。将评估教育材料在降低人类和猪囊虫病发病率以及作为次要结局的复发性癫痫发作和严重头痛发病率方面的有效性。如果有效,这种可持续的干预措施可以出口到撒哈拉以南非洲的其他养猪国家,以减少囊虫病和癫痫的发生率。 公共卫生相关性:脑囊虫病是一种由人与猪之间传播的绦虫引起的疾病,在卫生条件差的国家,这种绦虫是导致许多癫痫病例的原因。这项研究提出了在布基纳法索采取干预措施,以减少这种感染的流行。如果成功,癫痫的发病率将下降,大大改善这些社区的生活和健康。

项目成果

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Helene Carabin其他文献

Helene Carabin的其他文献

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{{ truncateString('Helene Carabin', 18)}}的其他基金

Using Host Responses to Neurocysticercosis to Develop Novel, Brain-imaging Free Diagnostics: a US-India Partnership
利用宿主对神经囊尾蚴病的反应来开发新颖的脑成像免费诊断方法:美印合作
  • 批准号:
    9316725
  • 财政年份:
    2016
  • 资助金额:
    $ 49.35万
  • 项目类别:
Understanding the inflammatory processes of neurocysticercosis: a US-India partne
了解神经囊尾蚴病的炎症过程:美印合作伙伴
  • 批准号:
    8337851
  • 财政年份:
    2011
  • 资助金额:
    $ 49.35万
  • 项目类别:
Understanding the inflammatory processes of neurocysticercosis: a US-India partne
了解神经囊尾蚴病的炎症过程:美印合作伙伴
  • 批准号:
    8246179
  • 财政年份:
    2011
  • 资助金额:
    $ 49.35万
  • 项目类别:
EFECAB: Improving pig management to prevent epilepsy in Burkina Faso
EFECAB:改善布基纳法索的生猪管理以预防癫痫
  • 批准号:
    8133621
  • 财政年份:
    2010
  • 资助金额:
    $ 49.35万
  • 项目类别:
EFECAB: Improving pig management to prevent epilepsy in Burkina Faso
EFECAB:改善布基纳法索的生猪管理以预防癫痫
  • 批准号:
    8459530
  • 财政年份:
    2010
  • 资助金额:
    $ 49.35万
  • 项目类别:
EFECAB: Improving pig management to prevent epilepsy in Burkina Faso
EFECAB:改善布基纳法索的生猪管理以预防癫痫
  • 批准号:
    7846576
  • 财政年份:
    2010
  • 资助金额:
    $ 49.35万
  • 项目类别:
EFECAB: Improving pig management to prevent epilepsy in Burkina Faso
EFECAB:改善布基纳法索的生猪管理以预防癫痫
  • 批准号:
    8077436
  • 财政年份:
    2010
  • 资助金额:
    $ 49.35万
  • 项目类别:
EFECAB: Improving pig management to prevent epilepsy in Burkina Faso
EFECAB:改善布基纳法索的生猪管理以预防癫痫
  • 批准号:
    8644952
  • 财政年份:
    2010
  • 资助金额:
    $ 49.35万
  • 项目类别:
HIV-CNS Diseases and Parasitic Zoonoses in the Eastern Cape, South Africa
南非东开普省的 HIV-CNS 疾病和人畜共患寄生虫病
  • 批准号:
    7849589
  • 财政年份:
    2009
  • 资助金额:
    $ 49.35万
  • 项目类别:
Epidemiology and Burden of Neurocysticercosis in Bukina Faso
布基纳法索神经囊尾蚴病的流行病学和负担
  • 批准号:
    7244100
  • 财政年份:
    2006
  • 资助金额:
    $ 49.35万
  • 项目类别:

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