EFECAB: Improving pig management to prevent epilepsy in Burkina Faso

EFECAB：改善布基纳法索的生猪管理以预防癫痫

• 批准号: 8259694
• 负责人: Helene Carabin
• 金额: $ 49.35万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8259694
• 关键词: Acute; Adult; Africa South of the Sahara; Agriculture; Antigens; Belgium; Biological Sciences; Burkina Faso; Central Africa; Cestoda; Child; Collaborations; Communities; Community Health; Community Trial; Costs and Benefits; Country; Cysticercosis; Dedications; Developed Countries; Development; Diagnosis; Disease; Doctor of Philosophy; Eastern Africa; Educational Intervention; Educational Materials; Educational workshop; Effectiveness; Effectiveness of Interventions; Epidemiologic Studies; Epidemiology; Epilepsy; Faculty; Family suidae; Fertility; France; Frequencies; Future; General Practitioners; Goals; Headache; Health; Health Information System; Health Sciences; Health education; High Prevalence; Human; Immunological Diagnosis; Incidence; Infection; Institutes; Intervention; Lead; Leadership; Life; Longevity; Medicine; Methods; Modeling; Neurocysticercosis; Neurologic; Neurologist; Nurses; Oklahoma; Participant; Persons; Physicians; Pilot Projects; Prevalence; Primary Health Care; Province; Psychiatrist; Psychologist; Public Health; Randomized; Recurrence; Research; Research Methodology; Research Personnel; Research Project Grants; Risk; Risk Factors; Rural; Rural Population; Science; Seizures; Serodiagnoses; Southern Africa; Staging; Students; System; Taenia solium; Tanzania; Testing; Training; Tropical Medicine; Universities; Veterinarians; Western Africa; Work; Zoonoses; base; college; control trial; cost; cost effective; cost effectiveness; effective intervention; farmer; follow-up; improved; nervous system disorder; post intervention; prevent; public health relevance; radiologist; research and development; secondary outcome; success; transmission process; working group

DESCRIPTION (provided by applicant): This proposal seeks support for a new initiative which extends the work of our pilot project, "Epidemiology and Burden of Neurocysticercosis in Bukina Faso" (R21 NS055353). Despite the fact that Burkina Faso is the second least developed country in the world, a strong research collaboration and dedication to improving the living conditions of the Burkinabi people made our pilot project, IFICAB ("Ivaluation du Fardeau Iconomique de la Cysticercose Au Burkina"), a success. The ultimate goal of the proposed project is to develop a sustainable, cost-beneficial and cost-effective intervention strategy to reduce the incidence and prevalence of neurocysticercosis (NCC) and associated neurological conditions across the lifespan. This proposal seeks to further strengthen research capacity through establishing reference centers for the immuno- diagnosis of cysticercosis in humans and pigs at the Institut de Recherche en Sciences de la Santi (IRSS) and for the radiological diagnosis of NCC at the Universiti de Ouagadougou. This will be done in conjunction with the creation of the Cysticercosis Working Group for Western and Central Africa, under the leadership of collaborators in Burkina Faso. Training two PhD students in neuroepidemiology and immunodiagnosis of cysticercosis and one masters student in public health is also proposed. Inclusion of epilepsy and NCC in the list of notifiable diseases for Burkina Faso will be pilot tested as a surveillance mechanism. Preliminary results indicate a high prevalence of epilepsy, NCC and cysticercosis in the three pilot villages studied. Based on these findings, we estimate that an educational intervention targeting pig farmers could reduce the incidence of infection in humans and pigs by one-half. We also estimate that this could result, in the long term, in reducing the incidence rate of recurrent seizures in Burkina Faso by 25% in villages where pigs are raised. We will use the PRECEDE PROCEED approach to develop educational materials to guide farmers in maximizing the monetary benefits of healthy pig raising. A pre-post randomized community trial will be conducted in 60 villages located in three provinces, using a 12-month baseline and 24 month post-intervention follow-up of 80 participants per village. The effectiveness of the educational materials in reducing the incidence rate of human and porcine cysticercosis, and of recurrent seizures and severe headaches as a secondary outcome, will be estimated. If effective, this sustainable intervention could be exported to other pig-raising countries in Sub- Saharan Africa to reduce the frequency of cysticercosis and epilepsy. PUBLIC HEALTH RELEVANCE: Neurocysticercosis is a disease caused by a tapeworm transmitted between humans and pigs that is responsible for many cases of epilepsy in countries where pigs are raised in poor sanitary conditions. This study proposes an intervention in Burkina Faso to reduce the prevalence this infection. If successful, the frequency of epilepsy will decline, greatly improving the life and health of these communities.

描述（由申请人提供）：该提案寻求支持一项新计划，该计划扩展了我们的试点项目“ Bukina Faso中神经囊肿的流行病学和负担”（R21 NS055353）。尽管布基纳法索是世界上第二个最不发达国家的国家，但强有力的研究合作和致力于改善burkinabi人民的生活条件，使我们的飞行员项目Ificab（“ Ivaluation du Fardeau du Fardeau du Fardeau du la la la cysticercose au burkina”），成功。拟议项目的最终目标是制定可持续的，成本效益和成本效益的干预策略，以降低整个寿命中神经囊肿（NCC）（NCC）（NCC）和相关神经系统状况的发病率和患病率。该提案旨在通过建立参考中心来进一步增强研究能力，以在人类和猪的免疫诊断中诊断，并在科学研究所（IRSS）（IRSS）以及在Ouagadougou大学对NCC的放射学诊断。这将与在布基纳法索合作者的领导下为西部和中非的囊性工作组创建。还提出了培训两名博士学位学生的神经性疾病学和囊肿性的免疫诊断，并提出了一名公共卫生硕士学位学生。将癫痫病和NCC纳入了布基纳法索的通知疾病列表中，将被试用作为监视机制。初步结果表明，研究的三个试点村庄中癫痫，NCC和囊肿性的患病率很高。根据这些发现，我们估计针对养猪者的教育干预措施可以将人类和猪感染的发生率减少一半。我们还估计，从长远来看，这可能会导致在养猪的村庄中，布基纳法索（Burkina Faso）的复发率降低25％。我们将使用先前的进展方法来开发教育材料，以指导农民最大程度地提高健康猪的货币益处。在三个省份的60个村庄中，将对每名村庄80个参与者进行12个月的基线和24个月的随访，将在位于三个省的60个村庄进行一项前随机审判。估计，将估计教育材料在降低人和猪囊肿的发病率以及重复的癫痫发作和严重头痛作为次要结果的有效性。如果有效，则可以将这种可持续干预措施出口到撒哈拉以南非洲以下的其他养猪国家，以降低囊肿和癫痫的频率。 公共卫生相关性：神经囊肿是一种疾病，是由于人类和猪之间传播的tap虫引起的，这些疾病是导致猪在不良卫生条件下饲养猪的国家中许多癫痫病的疾病。这项研究建议对布基纳法索进行干预，以减少这种感染的患病率。如果成功的话，癫痫的频率将下降，从而大大改善这些社区的生活和健康。