Cognitive Benefits of Interactive Mental and Physical Exercise for MCI

交互式身心锻炼对 MCI 的认知益处

• 批准号: 8496289
• 负责人: Cay Anderson-Hanley
• 金额: $ 32.96万
• 依托单位: UNION COLLEGE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8496289
• 关键词: Anterior; Assisted Living Facilities; Behavior Therapy; Behavioral; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Clinic; Clinical; Cognition; Cognitive; Data; Dementia; Effectiveness; Elderly; Electroencephalography; Enrollment; Evaluation; Exercise; Goals; Health; Hippocampus (Brain); Home environment; Impaired cognition; Independent Living; Individual; Institution; Internet; Intervention; Investigation; Lead; Link; Magnetic Resonance Imaging; Measures; Medical Research; Memory; Methods; Neurons; Outcome; Participant; Patients; Persons; Physiological; Population; Psyche structure; Public Health; Publications; Publishing; Randomized; Randomized Clinical Trials; Recommendation; Reporting; Research; Research Personnel; Risk; Risk Reduction; Site; Technology; Translating; brain volume; cingulate gyrus; cognitive change; cognitive function; executive function; experience; fitness; improved; interest; mild cognitive impairment; neuroimaging; neurophysiology; neuropsychological; novel; peer; public health relevance; virtual reality

DESCRIPTION (provided by applicant): The rise in dementia cases has led to calls for behavioral interventions to enhance brain health to delay the onset or progression of cognitive impairment. There is growing evidence of the cognitive benefits of exercise, but less is known about combined interventions. Our primary goal is to replicate and extend our recently concluded randomized clinical trial (RCT) investigating interactive physical and mental exercise, "Cybercycling for Cognitive Health" (Anderson-Hanley et al., 2012a). This RCT was conducted by the PI and collaborators with 63 independent living older adults. We found significant cognitive benefit after three months of simultaneously combined physical and mental exercise (i.e., exergaming), when contrasted with physical exercise alone. We compared physical exercise on a traditional stationary bike, with interactive physical and mental exercise on a "cybercycle." A cybercycle is a virtual reality-enhanced stationary bike with interactive cycling tours, on-screen competitors, and videogame capabilities. Results suggest that for the same effort, interactive physical and mental exercise on a cybercycle can yield greater cognitive benefit than physical exercise alone on a stationary bike. We wish to extend our research to persons with mild cognitive impairment (MCI), to examine the generalizability of the above finding to those already experiencing cognitive decline, with the hypothesis that cybercycling can slow decline more than either physical or mental exercise alone. We also aim to add to the scientific understanding of the phenomenon of increased cognitive benefit when physical and cognitive exercises are interactive, by comparing cybercycling with mental and physical exercise implemented individually. The primary method of this study will be an RCT (Aim 1), and we propose to enroll 81 patients with MCI. Participants will be randomized into one of three conditions for six months: cybercycle, stationary bike alone, or videogame alone. Comprehensive evaluations will include: neuropsychological (e.g., executive function and memory), behavioral (e.g., compliance and effort/watts), physiological (e.g., cardiorespiratory fitness), biomarker (e.g., BDNF), [deleted EEG/ERP] and an expanded neuroimaging pilot (n=30 MRI; Anderson-Hanley et al., 2012b). We expect that cognitive benefit will be greatest for the cybercycle condition, followed by physical exercise alone, and finally a smaller effect from mental exercise alone. To clarify mechanisms linking exercise to cognitive change (Aim 2), we will conduct secondary analyses of behavioral, physiological, biomarker, [deleted neurophysiological], and neuroimaging data. We plan to translate our scientific findings for application in the public health sphere, by synthesizing our results in presentations and publications, which should lead to wide dissemination and implications for interventions for persons with MCI (e.g., cybercycle placement in assisted living or home environments; Aim 3).

描述(由申请人提供)：痴呆症病例的增加导致了要求进行行为干预以增强大脑健康，以延缓认知障碍的发生或进展。越来越多的证据表明锻炼对认知有好处，但对联合干预的了解较少。我们的主要目标是复制和扩展我们最近结束的随机临床试验(RCT)，该试验调查了交互式体力和心理锻炼，“自行车运动促进认知健康”(Anderson-Hanley等人，2012a)。这项随机对照研究是由PI及其合作者对63名独立生活的老年人进行的。我们发现，与单独进行体育锻炼相比，同时进行三个月的体力和脑力联合锻炼(即努力玩游戏)对认知能力有显著的好处。我们比较了在传统固定自行车上进行的体育锻炼，以及在“赛车”上进行的交互式体力和心理锻炼。赛车是一种虚拟现实增强的固定自行车，具有互动自行车之旅、屏幕上的竞争对手和视频游戏功能。结果表明，对于同样的努力，在赛车上进行互动的身体和精神锻炼比单独在固定自行车上进行身体锻炼可以产生更大的认知益处。我们希望将我们的研究扩展到轻度认知障碍(MCI)患者，以检验上述发现对那些已经经历认知衰退的人的普适性，假设赛车运动比单独的体力或脑力锻炼更能减缓衰退。我们还旨在通过将赛车与单独进行的脑力和体力锻炼进行比较，来增加对身体和认知锻炼相互作用时认知益处增加的现象的科学理解。这项研究的主要方法将是随机对照试验(目标1)，我们建议招募81名MCI患者。参与者将被随机分成三种状态中的一种，为期六个月：骑自行车、只骑固定自行车或只玩电子游戏。综合评估将包括：神经心理(例如执行功能和记忆)、行为(例如遵从性和努力/瓦特)、生理(例如心肺健康)、生物标记物(例如BDNF)、[删除的脑电/事件相关电位]和扩大的神经成像试点(n=30 MRI；Anderson-Hanley等人，2012年b)。我们预计，赛博周期对认知的益处最大，其次是单独的体育锻炼，最后是单独的脑力锻炼的较小影响。为了阐明运动与认知变化的联系机制(目标2)，我们将对行为、生理、生物标记物、[删除的神经生理学]和神经成像数据进行二次分析。我们计划将我们的科学发现转化为公共卫生领域的应用，在演示和出版物中综合我们的结果，这将导致对MCI患者的干预措施的广泛传播和影响(例如，将网络周期安置在辅助生活或家庭环境中；目标3)。